6WW7,6Z3W,6WB9


Conserved Protein Domain Family
EMC10
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cd22209: EMC10 
ER membrane protein complex subunit 10 and similar proteins
Endoplasmic reticulum (ER) membrane protein complex subunit 10 (EMC10), also called hematopoietic signal peptide-containing membrane domain-containing protein 1 (HSM1) or INM02, is a bone marrow-derived angiogenic growth factor promoting angiogenesis and tissue repair in the heart after myocardial infarction. It stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK, and MAPK2 signaling pathways. Yeast EMC10 is a non-essential component of the ER membrane protein complex (EMC), which may be involved in ER-associated degradation (ERAD) and proper assembly of multi-pass transmembrane proteins.
Links
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Statistics
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PSSM-Id: 412067
Aligned: 104 rows
Threshold Bit Score: 38.565
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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oligomer
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface [polypeptide binding site]
Evidence:
  • Structure:6WW7: Homo sapiens EMC10 interacts with EMC1 and EMC7 within the nonameric ER membrane protein complex; contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                   # #  
6WW7_I        52 VGLLLEHSFeidd-----------sanFRKRGSLLWnqq-------dgTLSLSQRQLseeergrl--rdvaalnGLYRVR 111 human
6WB9_0        19 DILQLSYSDda--------------kdAIPLGTFEIdsts----dgnvTVTTVNIQDve-------------vsGEYCLN 67  Saccharomyces c...
TPP58615      27 LTLPLEHSLddg-------------qtFKQIRTIALhps-------agILTLEATGFsmteqdeqklldlsrknDLYHVR 86  Fasciola gigantica
CAX73550      22 SDYKPEHSFkd--------------gvFTKMDGIVLkissgelnlvssSHVFTDNEKqslle-------sakasNMYSVR 80  Schistosoma jap...
VDO09599      26 LDVVIEHSFdeg-------------ktFRPKGIISSwss-------egTTQLLNEPPltkeeqmm-laklalsdSLYVIR 84  Rodentolepis nana
NP_507807     22 WKITLEYSLnef-------------tnSYPLGSIEMsraf----dgnyTGTFKPAQEqnfgqk-----lfeaqnGVYSVR 79  Caenorhabditis ...
XP_003958670  12 AALCTQFSLyattl---------ersdEVSLGEFNMdve------srdISAFEPHNGmds-----------ltqGKYCVG 65  Kazachstania af...
NP_985028      7 AWLLLLFSRala-------------vlFEQQLLLYAedlal---rdrrPLAALWHTEgefevsd---mndalppGEYCVG 67  Eremothecium go...
XP_003678151   4 LCFLLFFSSalglkvslfmddlssnrkELLLGSFDIdvpsk---aitsKAFLEEVTFd---------------aGSYCIG 65  Naumovozyma cas...
GAV55906      12 VALCNELKLqlrniet----dmtvpwgFYNVDNVNLd-----------ASTLEPLSEerk------------dqGPYCVD 64  Zygosaccharomyc...

Feature 1          #            ##### #               # ##                                       
6WW7_I       112 IPRrpgaldgleaggYVSSFVPACslveshLSDQLTLHVDVa-------------------------------------- 153 human
6WB9_0        68 AQIegk------ldmPCFSYMKLRt----pLKYDLIVDVDEd-------------------------------------- 99  Saccharomyces c...
TPP58615      87 IRLsd--------sdVLESSVPACqlvgsaMKAKLVVSVNDh-------------------------------------- 120 Fasciola gigantica
CAX73550      81 IPVrn--------deYIEASIQSCqiiasrMRVKFTVSVNDl-------------------------------------- 114 Schistosoma jap...
VDO09599      85 AYAkpn-------sfVLMSSCQAShlmasdGKLALILSIDAs-------------------------------------- 119 Rodentolepis nana
NP_507807     80 ARSstq------pgqNFLTTSDPClflhsnLFHVFWLSISQekqqlhtltifpdtvawrsdtedgkyhseaklckdrsan 153 Caenorhabditis ...
XP_003958670  66 IKStdhv-----wdsDCFSFMELQv----pFSYDLVIQLDE--------------------------------------- 97  Kazachstania af...
NP_985028     68 AALpgk-------nySCFSYIDLAs----pWHYDLVVDTDAr-------------------------------------- 98  Eremothecium go...
XP_003678151  66 AKIeddet---qtevPCFSYLELEa----pLHHDIIVDIYD--------------------------------------- 99  Naumovozyma cas...
GAV55906      65 ALYngk-------liPCFSFLDVEs----pLHYNLVIDVHD--------------------------------------- 94  Zygosaccharomyc...

Feature 1               #### #                              #######
6WW7_I       154 ------GNVVGVSVvthpggcrgh-evedvdlelFNTSVQLQPPTTAPGP 196 human
6WB9_0       100 ------NEVKQVSLsyd--------------etnDAITATVRYPEAGPTA 129 Saccharomyces cerevisiae W303
TPP58615     121 ------GSPIAVHLatslfechp--akissrlptLSLTLDVQRPTVGASP 162 Fasciola gigantica
CAX73550     115 ------GDPIAIHMstpkyncpydistnylnlpdLSITLELQKPKLGSSP 158 Schistosoma japonicum
VDO09599     120 ------GSPIAISSvtsnqsftkd-pgsltsppqISTTVSFQKPALAIGP 162 Rodentolepis nana
NP_507807    154 vlqstqGTPKGVCHvvges-----------vlptPDTAAFVQKMEREKRA 192 Caenorhabditis elegans
XP_003958670  98 ------NTIQKVSLayn--------------ettEGIMPKLKETTDGPIA 127 Kazachstania africana CBS 2517
NP_985028     99 ------GNIIKLSLrpn--------------patEGLRPVVRQATPGPHA 128 Eremothecium gossypii ATCC 10895
XP_003678151 100 ------EELYKLTFsyn--------------ehhLGIIPIIREVTTGPTA 129 Naumovozyma castellii CBS 4309
GAV55906      95 ------QELKKLSLihn--------------pevSGIEPRVRTPIEGPEP 124 Zygosaccharomyces rouxii

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