Conserved Protein Domain Family
HOATZ-like
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pfam17664: HOATZ-like 
Cilia- and flagella-associated protein HOATZ-like
This entry represents cilia- and flagella-associated protein, HOATZ, and related proteins, found in metazoa. In mice HOATZ is encoded by the gene designated 4833427G06Rik (C11orf88). Mouse Hoatz mRNA is specifically expressed in tissues with motile cilia and flagella. Hoatz knockout mice developed hydrocephalus and male infertility, and the ependymal cilia frequently showed disorganized axonemes.
Links
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Statistics
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PSSM-Id: 465445
Aligned: 14 rows
Threshold Bit Score: 174.916
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EHB18719       1 METGPSSDLSFGTEYQEIYPP--GLLVFTGCSEQDANLAKQFWLRALMYPTNESQLVLTRASSQHLPVAGSSKSIVSsfs 78 
KAG3286503     1 METGPCSNSSNGKESHEICSP--GLLVFAGCSEQDANLAKQFWLGASMYPTNESQLVLSRGSSQRLPVARPTKNSVA--- 75 
XP_008259835   1 MEMGAREGRNGRKESPEICPP--GLLVFAGSSELDASLAKQFWLRASLYPPSESQLVLRQGSSQRLPVARASQSVAP--- 75 
Q32P68         1 METRPSSSLSSPEESCEAFPQ--GLLVFTGSSDRDANLAKQFWIGASMYPHNESQLVLSRGSSQRLPVARPSRSSAP--- 75  cattle
XP_005619850   1 METRAGGGLPSHQKSVEICPQ--G-LVFAGSSEQDSNLAKQFWIAASLYPTTESQLVLPRGSSQRLRVARPSRPPGH--- 74 
2_pfamImport   1 METRPRGSPSSLKESDETFPH--GPLVFAGSSEPDVNLAKQFWISASLYPPTESQLVLSRDSRQRLPVARPSGCSAS--- 75 
B6LI37        16 DEENYFD------DSCHIDTPvtGKTIFCGSSKEDVEYAKVFWKSITLQPPMESRLVSG-DTRQRLKVASASFQp----- 83  Florida lancelet
XP_007245300   2 EDMNDLDSLSEFEK---------YFTVFEGSSQEDVAYAKVFWNSLSLQPPVESSLVSV-DIRQRLKIAKTPQP------ 65 
XP_007494914   1 METGQGTGKTDEGEPLESADL--GPLVFSGSSEEDVALAKQFWVSASMHPHPESRLVLS-STEQRLPVAQTFRPPFV--- 74  gray short-tail...
XP_014396504   1 METRPGVGPSPGKKSCEIYPQ--GLLVFSGSSEKDTSLAKQFWITASMYPPNESQLVLSGSSSQRLPVARSSKS-STi-- 75  Brandt's bat

EHB18719      79 eNRLSLTLFPLES---ADVIAEALKIQESEEKVKYLQKvgqyfmhkdlllcqesptflsfkqAKKRDEILQLLRKQREER 155
KAG3286503    76 -EKSHLQHIPFENkkvTDFIANTLRIQESEEKMKYLQK------------------------AKKRDEILQLLRKQREER 130
XP_008259835  76 -EKSHSQPSSLERnknPDIIAEALKMQESEEKMMYLQK------------------------AKKRDEILQLLRKQREER 130
Q32P68        76 -EKTYFQPFFLEEsksRDVTAETLKIQESEEKKKYLQK------------------------AKKRDEIIQLLRKQREER 130 cattle
XP_005619850  75 -EKVYLQPFSLEKnknTDVTAETIKIQESEEKEKYLQK------------------------AKRRDEILQLLRKQREER 129
2_pfamImport  76 -EKCHFQPFPSENnkgTEV-EEALKVQRSVEKLEYLQE------------------------AKKRDEILQLLRKQREER 129
B6LI37        84 -KNFAHEPVPDSPr-lTQFLEEAHRQEHVEETEKRRQL------------------------SIKKEQQQLLLQKQREER 137 Florida lancelet
XP_007245300  66 ---TNSGSKQSADsknEEILQKAYQRQMQDEKKRYMEM------------------------AKKRDEIMVLLKKQREER 118
XP_007494914  75 -----ERHFDFAYyktEEYLEQERKFREIEEKEKYIQK------------------------Tlhiqfafkgvpa----- 120 gray short-tail...
XP_014396504  76 -EKSLLQSLSLEKnkgTDAIDETLKM---EEKKKYLEK------------------------AKRRDEILQLLKKQREER 127 Brandt's bat

EHB18719     156 ILKEFISLPYKRMDKVHNK---KQVLSESEKKDQEEVKALD 193
KAG3286503   131 ITKELISLPYKPKSKEHKA---KEEVSETDKEDQEEVKALR 168
XP_008259835 131 ITKELISLPYKPKVKVQKP---KTVTSESDKEDQEAVKALD 168
Q32P68       131 ILKELISLPHKPKGKVHKA---KKVISESDKEDQEEVKALD 168 cattle
XP_005619850 130 ILKELVSLPYKPKAKVHKA---KKVILKSDKEDQEEVKALD 167
2_pfamImport 130 IMKEMISLRCKPKTKVHKA---KKEISESEKQDQEEVKALD 167
B6LI37       138 MQREEILRGHKPRQRTELI---HLPTSSDEEQEEDPMLELD 175 Florida lancelet
XP_007245300 119 IKKEMISLQHRPRRSDQTErcyIQTPSETLDEDIKEVQALT 159
XP_007494914     -----------------------------------------     gray short-tailed opossum
XP_014396504 128 ISKELVSLPYKPKSKVCKA---KKVIPESNKEDQEEVKALN 165 Brandt's bat
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