2E63


Conserved Protein Domain Family
SPRY_NHR_like
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cd12887: SPRY_NHR_like 
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SPRY domain in neuralized homology repeat
This family contains the neuralized homology repeat 1 (NHR1) domain similar to the SPRY domain (known to mediate specific protein-protein interactions) at the C-terminus of a conserved region within eukaryotic neuralized and neuralized-like proteins. In Drosophila, the neuralized protein (Neur) belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the nervous system. Neur binds to the Notch receptor ligand Delta through its first NHR1 domain and mediates its ubiquitination for endocytosis. Multiple copies of this region are found in some members of the family.
Links
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Statistics
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PSSM-Id: 293945
Aligned: 73 rows
Threshold Bit Score: 133.788
Created: 14-Jun-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2E63_A         8 ELHPRTGrLVSLSAcgRTARRqqpgqeFNHGLVLSREPLrDGRVFTVRIdrkvnsWSGSIEIGVTALDPs---------- 77  human
NP_611963     64 RFHPYHGsNIQLGDdaTVAYRra---sFADALTFSERPLaPGDIFLVEIekiergWSGHMRLGLTELAPnvi-------- 132 fruit fly
AEE62208      36 KFLPYHGaYIQLSEnnTVACRnk---sFANSITFSERPLqPGEIFLVEIeqnesgWSGHMRLGLTQLDPlem-------- 104 mountain pine b...
XP_002735260   5 RFHGNHGtNLVLSEg-GVVARrt--csFANAITFSERPLkVGEVFLVEIegqergWSGHLRCGLTQHNPvlmtnnvddss 81  Saccoglossus ko...
Q9D0S4        25 RFHQVHGaNIRMDPsgTRATRve---sFAHGVCFSREPLaPGQVFLVEIeekelgWCGHLRLGLTALDPa---------- 91  house mouse
XP_001623930   3 RFHPKHGsHITLSPcqTVATRck---sFANAVVFSNRPLsTSETFVFEIyeqeqgWSGHVRCGVTTHNPn---------- 69  starlet sea ane...
XP_003247301  13 RFHRFHGyNLSLHEqdTVAHRem---sFANAIVFSEQSLsPGEVFLIEIessengWSGHIRLGLTQLDPdalqrs---gh 86  pea aphid
XP_002112009   2 KFHECRGlNISLSNdgKAAARth---gFSNGIVFSSRPIrPNEVFTILIeeiqpdWSGNLRCGFTWENId---------- 68  Trichoplax adha...
XP_001636847   3 FHPSKHGrFIKLSKnfTSATReg--dtYDYGVVYSDRPIhLGEVFQLQIdqvetkWAGSLRIGVTLKNPnc--------- 71  starlet sea ane...
NP_001077300  10 EFHSVHGtNVQLDPsrTRATRve---sFANGVCFSKDPLsPGEIFLVEIeekelgWCGHLRIGLTAHDPr---------- 76  zebrafish

2E63_A        78 ---VLDFPs--SATGLKg----gSWVVS-------------GCSVLRDGR---------------------------SVL 108 human
NP_611963    133 rtsSEGLPh-fALPDLAnl--gnSWIYPis---------kfEMNQRQDANdiiepetdda-------phrnllgdatHVR 193 fruit fly
AEE62208     105 -yrRQSIPq-yALPDLVdm--gkSWIYGis---------kaHNNILEYMLdtrvlgvdqgymyvkygnrpefnnynsHIE 171 mountain pine b...
XP_002735260  82 kpdQIKIPq-ySMPDLAnm--gkTWIFAit---------ksHNRVPSANRenedsstl------------rpvhrkpFIE 137 Saccoglossus ko...
Q9D0S4        92 --sLAAVPe-fSLPDLVsl--ghSWVFAit---------rhHNRVPREGQpeaeaavpsgpqa-llvepylrieqfrIPR 156 house mouse
XP_001623930  70 ---FIKVPp-yLLPDLAqm--gtTWVFAl-----------kPSNNKPLGD---------------------------EQL 105 starlet sea ane...
XP_003247301  87 llpQCAIP---DMVSNKtm--geSWVCAltkhqawydanylTNYFRLDGN---------------------------HVF 134 pea aphid
XP_002112009  69 --rHFEVPe-ySLPGMTnq--gkTRVIA-------------LPTKIAISD---------------------------ELK 103 Trichoplax adha...
XP_001636847  72 -pqTVVVR---AVTDLFvedckdYWILS-------------GSRVHNGSY---------------------------EKD 107 starlet sea ane...
NP_001077300  77 ---TLDTVpeySLPDLV------EKGDSw------------VFAITRNHN---------------------------KVT 108 zebrafish

2E63_A       109 EEYGq------------------DLDQLg-------------------------EGDRVGVERTVa------GELRLWVN 139 human
NP_611963    194 TPRGllpkrllr----pamgngnDSDILlt-----------------------dKGSRIGIIYVPtvqsdskGELHFIIN 246 fruit fly
AEE62208     172 TCRGsv---------------pvSLLKPtrgcdd---------------ilptdMGSRIGVMYIPvdd--keAEMHYIIN 219 mountain pine b...
XP_002735260 138 DFIGyircgsvnipkhmlvgkdkSGGELva----------------------tcNGSRIGVTYEIvd---gvAEMHFLIN 192 Saccoglossus ko...
Q9D0S4       157 DRLVgrsrp---------glyshLLDQLyeqnv----------------lpptaRRSRLGVLFCPred--gtADMHIIIN 209 house mouse
XP_001623930 106 RECGh------------------NYQRLpqedevdntiycgekaatnsnirptdEGSRIGIRVSYa------GNLYFYIN 161 starlet sea ane...
XP_003247301 135 TSRGtfptsil------kssgheKMDILpt-----------------------dVGSRVGVLYLPcgq--nmAVMHFIIN 183 pea aphid
XP_002112009 104 DEGSp------------------KHVLLd-------------------------EGTTIGLKYNLk------GQIHLIIN 134 Trichoplax adha...
XP_001636847 108 SDLN-------------------VHSLK--------------------------QKDRIGVQVTAk------GDLVFFVN 136 starlet sea ane...
NP_001077300 109 EDEGa------------------EVEQPn-------------------------EGNDTSNKPKTf-----fTDTHLYIE 140 zebrafish

2E63_A       140 ----GRDCGVAAtgl---pprVWAVVDLYG-----KCTQITVL 170 human
NP_611963    247 ----GVDRGPVSrdiplnrapLFVVIDVYG-----TTKQIRII 280 fruit fly
AEE62208     220 ----GVDMGTCAkhipykntpLHVVVDVYG-----TTKKVRII 253 mountain pine beetle
XP_002735260 193 ----GEDQGAAImdqadldrpFYCVVDVYG-----TTKRVRVI 226 Saccoglossus kowalevskii
Q9D0S4       210 ----GEDMGPSArglp-aaqpLYAVVDVFA-----STKSVRLV 242 house mouse
XP_001623930 162 ----GKKFGPCAtdlp-sdseLFVTLDVYG-----STKAVKII 194 starlet sea anemone
XP_003247301 184 ----GEFVVPLSrtipyndgpIRAVIDVYG-----ATKRVRVI 217 pea aphid
XP_002112009 135 ----HTDLGPVVqnvl-inqdVYAIVDIYG-----STTKVKVL 167 Trichoplax adhaerens
XP_001636847 137 ----GICKGIAMtglp-tkkeLFVIFDVYG-----RTKEVSWK 169 starlet sea anemone
NP_001077300 141 nmgiPRDKLVGRsrp---grfSHILDDLYKtnalpPTARRSRI 180 zebrafish
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