Conserved Protein Domain Family
TFP_LU_ECD_Crim
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cd23591: TFP_LU_ECD_Crim 
extracellular domain (ECD) found in Drosophila melanogaster protein crimpled and similar proteins
Crimpled (Crim) is a member of the Drosophila Ly6 superfamily. It is required for septate junction (SJ) formation and function in a tissue-autonomous manner. Crimpled contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Links
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Statistics
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PSSM-Id: 467120
Aligned: 18 rows
Threshold Bit Score: 132.085
Created: 7-Oct-2021
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_648500      21 SAIWCYRCTSAt-PGCAEKFNWRgigfLGEHCPEp-----DDICVKVTERrGARETITRDCLSALsfrk-----dipaDK 89   fruit fly
XP_023349751   13 RGLICNQCIGTh-PGCSIFNYNWh---WGVECGRr-----FDKCVKLIERrGSDTLITRDCLSNLeafrv----dipaDK 79   Eurytemora af...
OQV12111       22 HSLRCYACMGTq-PGCSADRLDWhl-vKNMECPDv-----QDVCVKITEKiLGTYLTTRGCMSIMtslrr----dipgDH 90   Hypsibius duj...
TPP66198       18 GQLYCYECSSAq-SGCGDPIDVRl--mHWKRCTGrr--viEDYCVKLIEKvDDQITVTRGCLSDLllntqhresipqvRR 92   Fasciola giga...
ELT89870       20 LSLQCYRCHSSq-PGCGKELNIRl--qHWHSCPNvgdgggENFCVKVIERkGSEISILRECLMTLryntghrekmptiQR 96   Capitella teleta
XP_014662136   19 LAIRCYSCTVPpyPGADLHTNKRni-cPDISCPGpk---eEQVCVKITDNrGSEEVIVRGCLWDLrssnwa--pllpgDV 92   Priapulus cau...
VZI06984     1620 QELWCYACSSAq-SGCGPPIDVRl--mHWRLCKGvp--vhEQMCVKLIEKvNDQVIVTRGCLSDLlltaqirldmpkvRR 1694 Sparganum pro...
XP_022302263   20 SAIMCHRCVSAm-GGCGDDLDWRm--fPWRDCGD------SEFCVKIIKKvGSEHNIVRDCESSLmrstrhrmlmpnlRR 90   eastern oyster
XP_013398535   24 PPSYCYSCTSNq-PGCGNVLSEWv--qRWVECGE------QTMCVKVYQVvNGQEQITRGCLNQLmkntiyredmptnRR 94   Lingula anatina
XP_017491859    1 SSLLCYTCTSNe-PGCTLDKVDWli-hSATSCPNy-----NDKCVKIIETtGADTKVVRGCLSAVmpyrr----dipaDH 69   snowberry fru...

NP_648500      90 YEGCRPAAHDeklanyvnht-----ikehdvrrdYYTDTTFCFCFLDHRCNGA 137  fruit fly
XP_023349751   80 YEGCHAASSDpklgvyvqns-----ipeldikrrYYSNVTWCFCSFDHWCNSS 127  Eurytemora affinis
OQV12111       91 YEGCRRGAEDvrynkdvqa-------yhphqnavSTGDVTFCFCAWDNYCNNG 136  Hypsibius dujardini
TPP66198       93 QGYCGNSRDYqiyllshlvgnelaqtamglftdqHEDFKRYCFCNDWNGCNTS 145  Fasciola gigantica
ELT89870       97 HGYCEPARNNdpw-------------------nmVDTDQQYCFCNDWNGCNTA 130  Capitella teleta
XP_014662136   93 FTGCRKPAVDkyltpndy---------ylnvykqPHESIDFCFCNDWIWCNGA 136  Priapulus caudatus
VZI06984     1695 HGYCLYSISNqqylqshlrgeeltvwamgslrpeTENYKLFCFCNDWSGCNSA 1747 Sparganum proliferum
XP_022302263   91 HGYCLPARKNdasn----------------pmdtENENVMYCFCNDWNGCNSA 127  eastern oyster
XP_013398535   95 HNYCLPGRGSassavy-------------pgsqtQDSQRTYCFCDDWNGCNHA 134  Lingula anatina
XP_017491859   70 YEGCRPATFSpkknvyvyne-----ikelqlnqrPYNNITYCFCEFDHWCNGG 117  snowberry fruit fly
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