Conserved Protein Domain Family
bHLH_dnHLH_EMC_like
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cd19695: bHLH_dnHLH_EMC_like 
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein extra-macrochaetae and similar proteins
Extra-macrochaetae is a negative regulator of sensory organ development in Drosophila. It belongs to dominant negative group of helix-loop-helix (dnHLH) proteins, which lack a basic DNA-binding domain but can form heterodimers with other HLH proteins, thereby inhibiting DNA binding.
Links
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Statistics
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PSSM-Id: 381538
Aligned: 8 rows
Threshold Bit Score: 67.3944
Created: 2-Aug-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative dimer
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
  • Comment:HLH region of bHLH forms homo- and heterodimers
  • Comment:Based on the structure evidence that Homo sapiens ID-2 (4AYA) forms a homodimer.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  ##  ## ##  #           ##  ## ## ### ##  #   #
P18491        32 GDGENAEMKMYLSKLKDLVPFMpknRKLTKLEIIQHVIDYICDLQTELETHP 83  fruit fly
EFX87275      40 TSKEQVEIQMYLSKLKELVPHMpknRKVSKLEVIQHVIDYICDLQSELEQNH 91  common water flea
XP_018019017  76 TLQEKRELLEYFQKLRVLVPSLpktGKIPKLEVIEHVITYIKQLENQLIDHP 127 Hyalella azteca
XP_009028953 100 NNDDDNQMSIYYTQLQNLLPQPqinNPQSRLQLLQNVIDYIADLEEMTSSSE 151 Helobdella robusta
GAU99050      33 ENEEMATMELLFHKLLHMIPTLpkdRKVSRLEILQHVIEYIQDLESQVQFHP 84  Ramazzottius varieornatus
CDW57046      41 LDTTRLLEALVYKRLRAMVPGVpkkSPVTKMQLLQHVLDYIYDLQEQLREPV 92  human whipworm
CDW57048      30 SLKRSGEGAATMAQLRQLVPSLrqmTISDELEFLQHVIDYIQDLETQLTDHE 81  human whipworm
KHN81817      31 LSQERRERKETLAKLQRIVPTAr--EGISQLELLQRIIDYIADLQAQVDAFS 80  dog roundworm

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