4JS1


Conserved Protein Domain Family
GT29_ST6GAL1_2

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cd23968: GT29_ST6GAL1_2 
beta-galactoside alpha-2,6-sialyltransferase 1 and 2
ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).
Statistics
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PSSM-Id: 467696
Aligned: 22 rows
Threshold Bit Score: 323.068
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:4JS1: Human beta-galactoside alpha-2,6-sialyltransferase 1 binds cytidine and phosphate, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                   ###                  
4JS1_A        49 AEALRCHLRDHvnvsmvevtdfpfnts--------ewegylpkesirtkagPWGRCAVVSSAGSlkssqlGREIDD-HDA 119 human
CBQ74112      86 ARRLLCSLQSAarfrtlpadespwkqlg-------ygdiearpgllqlyagGFRTCAAVMSSGAmlgsrlGKDILDsHDA 158 Florida lancelet
CBQ74117     154 SEELLCDMKKKvvlkifqrgdlffrsq--------qldqyfmpeplfspkrTYNTCAIVTSAGSlinselGPFIDS-HDF 224 Caligus rogercr...
YP_009408343  68 KNDVYCALKNAanniml----------------------------yseltnIYNKCALVTSSGSllgskhGSDIDS-HDA 118 Murmansk poxvirus
XP_035664559  46 QELLYCRLKKIpfstisskspsfrry----------pfrqhfpevtlqetvHFNTCAVVSSSHAmrthlyGKEIDA-HDA 114
XP_035659695 135 REDMYCKMKTKipfstinknstnfenr---------sdeevlpeeslenlvSYNSCAIVSSSHAlmvhkyGGEIDA-HDA 204
XP_035695399  79 KNALYCRLKKVsfstmtrtlpppsngs---------vlnpyfpseslenlvRYNSCAVVSSSHGlklhnyGHDIDS-HDA 148
XP_035680351  60 KHDLLCELKNRvwfktlpstegpfkaln-------ysllepkntlyqlhhdGFKTCAAVMNSAAilgsnlGEEIDS-HDA 131
XP_035714739 180 AKAVLCRLKKAgikliaqnsvgafadkvfpteplfgnregdtfsasvepqpLYKTCAVIPNSAAfdgarhGIDIDS-HDF 258
Q96JF0       248 RAQLLCQLRSRarvrtldgteapfsalg-------wrrlvpavplsqlhprGLRSCAVVMSAGAilnsslGEEIDS-HDA 319 human
Feature 1           ##                     #                                                     
4JS1_A       120 VLRFNgAPTANfq-qDVGtKTTIRLMNSqlvttekr--------flkdslynEGILIVWDPSvyhsdipkw--------- 181 human
CBQ74112     159 VLRYNsAPTKRyq-sDVGsKTTLRLMNSqvvvkqsky------hwftdpryrNVTMVLWDPMsyggtmaeq--------- 222 Florida lancelet
CBQ74117     225 VMRFNdAPTFGhe-kDVGsKTSLRVVNSqilsrpefg------fldpknlysHSPVLVWDPTnynvsigew--------- 288 Caligus rogercr...
YP_009408343 119 VIRFNdAVVKGfq-kDIGsKTSLRIVNSqlvfkr------------plfsrrLSNIAVWDPSkyneni------------ 173 Murmansk poxvirus
XP_035664559 115 VLRFNcAVVKTfe-eFVGsNTTLRLINSqvpsssktshc--ktdfwktnssfRQEILVMRNVnsitgnlar--------- 182
XP_035659695 205 ILRFNcAPTDKfe-eFVGsRTDMRLINTkipgrt------------ckkefwNDSIAMFNHEftvvrnfdairlk----- 266
XP_035695399 149 VLRFNcAPTQGfs-aHVGsRTDIRLINTqipektctde----fwderikmfnNETVVIRNFDsirvvrgki--------- 214
XP_035680351 132 VMRFNnAPLSEeyraDIGvKTTLRLMNSqlladpsfn-------fftdpiyrNITMIVWDPAaytgdmeew--------- 195
XP_035714739 259 IMRFNnAPTAGye-sDVGsLTSLRIVNSqvvtkpqfhfprrqrnsptnkvkgHPINTTSKSGtasddrttraelaamdvd 337
Q96JF0       320 VLRFNsAPTRGye-kDVGnKTTIRIINSqiltnpshh-------fidsslykDVILVAWDPApysanlnlw--------- 382 human
Feature 1                                                                                        
4JS1_A       182 ---------------------yqnpdynfFNNYKTYRKLHPn--QPFYILk-pQMPWELWDILQEIspeei----qpnpp 233 human
CBQ74112     223 --------------------wykkpdfnlFPAYEKRRRESPw--EHVYIMd-pRYLWELWEVLHRNtreki----vrnvp 275 Florida lancelet
CBQ74117     289 ---------------------ysspdkpfFETFFSKRLVKPe--EALYLLh-pGSLWSLWDWLQSHskwpl----vpnpp 340 Caligus rogercr...
YP_009408343 174 ------------------------tswltNPEFNFFPILRNk--KDYDIIs-pKFIWKLWDVIQSYhpeki----qpnpp 222 Murmansk poxvirus
XP_035664559 183 ---------------------dkkerfgaIRNYVRYRQSFHs--GAFFVHt--PGFHEAVHQLQTGfcrktgtctkrrss 237
XP_035659695 267 ----------------prgidtkkdrfrvFENLKKFRRTHPn--RTMPFIqrpNFGKDIVTELGRFcsttgrckrtsksp 328
XP_035695399 215 --------------------dtrkdkyksFFNYIRYRKMYPn--STTHFIqrsNFGLDLRNELKRFcettkgckpskmsp 272
XP_035680351 196 ---------------------yqnpdanfFSSYEQRRRMFPr--ENLYITd-pRFYWELWDVLQENteami----hpnpp 247
XP_035714739 338 avweatpkflvwdpcmysaslddwvkkpdFPLFEKYFNLTKeerNRFYLLd-cRLIWKFWEILQEYsfvki----ygnpp 412
Q96JF0       383 ---------------------ykkpdynlFTPYIQHRQRNPn--QPFYILh-pKFIWQLWDIIQENtkeki----qpnpp 434 human
Feature 1        ###                 ##          ###                     #                       
4JS1_A       234 SSGMLGIIIMMTlCDQVDIYEFlpsk--rktDVCYYYQKFfdsac------tmgayHPLLYEKNLVKHLnqgtdediyll 305 human
CBQ74112     276 SSGFMGIHLLLSlCDTVDVYEYvpsk--retQRCHYYGEEmdiac------tygayHPLRAEKELIKKLnigpeedvrnk 347 Florida lancelet
CBQ74117     341 TSGFIGLALSAQqCKVIRVFEYipsl--rysDKCHYYGSDpasevgsggpctygawHPVSAEKLMALALnvgkkkdiyah 418 Caligus rogercr...
YP_009408343 223 SSGFIGIVIAMQmCDSVTIYEYips---kqtDLCHYWTREinpfc------sqgsyHPITFEKNIIKNIgni-----kap 288 Murmansk poxvirus
XP_035664559 238 TSGFLGVLMMLHiCDWVTLYEMvpsvagqrdKREYYWDDVkvmtrg-----akestHSYSADRTVMRKLavnse-eidst 311
XP_035659695 329 STGMFGIVMMLHlCNWVHVYEIlpsn-kddtNLRYYYDEKakllk------ptggvHSYSQEQQYIRTLsltsdqdiant 401
XP_035695399 273 SSGSLGVIMMLHlCDWVYTYEIvpss-vdktRLAYYYSGNitkn--------hnafHSIATERQYFRTLtvtppdevert 343
XP_035680351 248 SSGFQGIAVMLSlCDQLDVYEFvpse--risMKCHYYEKWklnpac-----tlgwwHDLRAEKYFILRMnqgtkdditkk 320
XP_035714739 413 TSGFIGIMLSLQvCERVNVYEYipsv--resARCHYYGPRnesnps----ctygawHPVSAEKLFFLSLsdgtdkgvfid 486
Q96JF0       435 SSGFIGILIMMSmCREVHVYEYipsv--rqtELCHYHELYydaac------tlgayHPLLYEKLLVQRLnmgtqgdlhrk 506 human
Feature 1                
4JS1_A       306 GKATLPGF 313 human
CBQ74112     348 GKITLPGF 355 Florida lancelet
CBQ74117     419 GYLTIPGL 426 Caligus rogercresseyi
YP_009408343 289 GIITLNGF 296 Murmansk poxvirus
XP_035664559 312 GRATLKGF 319
XP_035659695 402 GVALLKGL 409
XP_035695399 344 GVAVFRGL 351
XP_035680351 321 GKVTLSGY 328
XP_035714739 487 GVLTLPGI 494
Q96JF0       507 GKVVLPGF 514 human

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