5ELT,5ELT


Conserved Protein Domain Family
KH-I_KHDRBS

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cd22384: KH-I_KHDRBS 
type I K homology (KH) RNA-binding domain found in the KH domain-containing, RNA-binding, signal transduction-associated protein (KHDRBS) family
The KHDRBS family includes three members, KHDRBS1-3. KHDRBS1, also called GAP-associated tyrosine phosphoprotein p62, or Src-associated in mitosis 68 kDa protein, or Sam68, or p21 Ras GTPase-activating protein-associated p62, or p68, is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. It binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. It also binds poly(A). KHDRBS1 acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. It is recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. KHDRBS2, also called Sam68-like mammalian protein 1, or SLM-1, is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. It binds both poly(A) and poly(U) homopolymers. KHDRBS2 may function as an adapter protein for Src kinases during mitosis. KHDRBS3, also called RNA-binding protein T-Star, or Sam68-like mammalian protein 2, or SLM-2, or Sam68-like phosphotyrosine protein, is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. It binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. It also binds poly(A). KHDRBS3 may play a role as a negative regulator of cell growth.
Statistics
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PSSM-Id: 411812
Aligned: 19 rows
Threshold Bit Score: 151.282
Created: 19-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA bindingGXXG motif
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:5ELT: Homo sapiens KHDRBS3 in complex with RNA; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           # ### #####  ##         ###    ###                           
5ELT_B        54 KNMKLGQKVLIPVKQFPkFNFVGKLLGPRGNSLKRLQEETlTKMSILGKGSMRDKAKEEELRksgeakyfHLNDDLHVLI 133 human
P13230        70 TKVKLVSRCCLPVDQFPkYNFLGKLLGPGGSTMKQLQDETmTKISILGRGSMRDRNKEEELRnsgdvkyaHLNEQLHIEI 149 Artemia salina
EDO44127      45 KPVKLSEKVFIPVKDHPkFNFVGKLLGPRGNTFKRLQNSTgTKMSILGKGSMRDKEKEEELRatedpkyaHLGEELHVLI 124 starlet sea ane...
EDV23041      75 SAIKLSERVLIPVKDYPgFNFIGKLLGPRGNTLKRLQSDTlTKMSILGKGSIRDKEKEEELRrdd--pssHLHLDLHVLI 152 Trichoplax adha...
XP_003383496  63 PDKSLKEKIYIPIEDQKnYNLVGRLLGPKGLTLKRIQAETdTKISILGRGSIKDKSKEEEYRnsgkemyaHLTDELHVLI 142 Amphimedon quee...
XP_006812553  31 KPIRVSERVIVPVKDHPkFNFIGKILGPRGNSLKRMQTETgTKISILGKGSMRDKKREDDLRaggeakfsHLSEELHILV 110 Saccoglossus ko...
XP_013076155  57 RQQKCSLKIRIPVKEHPrYNFVGKLLGPKGQTLKALQDQTgCKMAVMGKGSMREKEKEEELRkegg-kyaHLNEDLHVLV 135 Biomphalaria gl...
XP_018654114  57 KPVKVRAKIEIPQEQYPaINFVGKLLGPGGQTLRAVQETTkTKMAILGAGSLRDDAKEKQLLsngdpkyqHLKQKLHLQV 136 Schistosoma man...
XP_018670868  64 KYPKVECNIRIPVNEFPrVNFIGRLIGPGGSTLKGIQEVTnTRIAILGKGSLRDKKKAEELAnssdvkynHLKYPLHVRI 143 vase tunicate
XP_029849453  25 RSIRLQVRVQVPVKDHPnFNFVGKLLGPKGNSLKRLQEETqTKMAILGRGSMRDKAKEEELRkqkepkywHLHEELHVEV 104 black-legged tick
Feature 1                              
5ELT_B       134 EVFapPAEAYARMGHALEEIKK 155 human
P13230       150 ISIasPAEAHARMAYALTEIKK 171 Artemia salina
EDO44127     125 EVEapPGQAHARLGIAIEEIKK 146 starlet sea anemone
EDV23041     153 EVEapYHEAHQRLCASVEALRK 174 Trichoplax adhaerens
XP_003383496 143 ESI--PPNAVQKLAAGIAEVRK 162 Amphimedon queenslandica
XP_006812553 111 EAYslPPDAHTRVGHALRELRK 132 Saccoglossus kowalevskii
XP_013076155 136 ECFtdITDGYHRLAGALVELRK 157 Biomphalaria glabrata
XP_018654114 137 DSLgpPSESCYRLAHALAEVRK 158 Schistosoma mansoni
XP_018670868 144 SAIgsVDQAYMSIGRACSEVSK 165 vase tunicate
XP_029849453 105 SAFapPAEAYGRMAHALSQLKP 126 black-legged tick

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