Conserved Protein Domain Family
Membralin

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pfam09746: Membralin 
Tumour-associated protein
Membralin is evolutionarily highly conserved; though it seems to represent a unique protein family. The protein appears to contain several transmembrane regions. In humans it is expressed in certain cancers, particularly ovarian cancers. Membralin-like gene homologs have been identified in plants including grape, cotton and tomato.
Statistics
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PSSM-Id: 462877
Aligned: 13 rows
Threshold Bit Score: 383.729
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFX71033      20 NQLATVRdrMFHAIFHRMAIAYARTFPKPIRRLLEWLFLLKALAAFLMLLYIHIIFSRSPITCLDHIKADWPREGIVRID 99  
2_pfamImport   1 NHLNAAR--LFHAMLVRVALKYSSKVPLKWRKVIEGAVLFLALILFFSLTFIHFNFTKTPIKCMDIMKPDWIRQGIVRIE 78  
XP_002600544  12 NHLGNVRdrLFHALFFKVAITYARAFPKPVRRVFEFLVLLKALVVLFILVYIHIAFSRTPITCLDHVQKEWPRDGILRVE 91  
1_pfamImport   1 DPLLTARdrLFHVLFFNMALIYSRLFPPTFRRVFEFFVLLKALFVLFILAYVHTAFSPEPINCSQYRWSDNPGTGLLQVE 80  
XP_009024019  21 HPFFNVRerLFHALFHRIAVAYCRAVPSSFRIALEIFALLKALVLFFVLCYIHVVLARGPKHCLQHIKQNWPRDGVLRVE 100 
Q7K4L9        44 NNMMNMRdrLFHAIYFRAAATYAELVPRKVQLTIEFLLLAKALLFFFTLIYVHNSFIKNPCTCLQDVKN-WPREGVIRVE 122  fruit fly
3_pfamImport   1 NQELIVEegLLFYMLYWATLEYATIIPRFLRRVIEFVFLLQAVFSIFLLIYVHINFSQEPAGCFDLVKDIWPRDGVLRVE 80  
XP_016657149  35 SQELGLLesLFCDIFFNANRGYARIFSRSLRRVIEFIFLLQAVLSFFVLVYVHVRFSRMPANCLDNVKNVWPRDGILRVE 114 
4_pfamImport   1 NQQLHLLetLLWVMIFNATFKYARTFPNSLRRVIEVVLLLQAFSSFFILVYVHINFTRIPASCLDHVKDIWPRDGILRVE 80  
XP_003373324  11 GALGTPRdrLFQALYYRAAYIYHITVAVSVRRFIEFIVLLMAILLFGLVTYVHIVFTRQQPSCLESVRHLWPRNGILNVH 90  
XP_003137694  46 NQFGAVRdrLFHAMLVRVAISYNRHVPMLGKRFIEFSSLITAIILLSIMVYVHHFFDETDSNCLAPFMDQWPRNGVLRVE 125 
XP_003098362  54 NSLNAARdrLFHAMLVRIALKYSGRVSLRWRKAIEGSILFVALLLFASLIFIHFNFTRSPATCLDSMQADWIRKGIVRIE 133 
XP_002125973 105 sdiwprngilraqvsyneslpnyklyfssqhlddskmsvqstgynmeyeytvpiqnnqlsnlkqwqadlfqkypfaiqnl 184  vase tunicate
EFX71033     100 ITRSgngpd----iqgysLHHSYAKEQRIHQR----------EQFEYQAMFGFWSGPYSSSADSEETESSALKETTElLS 165 
2_pfamImport  79 IVQN--------------LDVLEEKEHFINQYisersarvchFNPADVFRFGPSVIPTAMRNEQRSDEVTKSKISEP-RP 143 
XP_002600544  92 IQRNstr--------pplFLYDYESESGIPGLe----------------------------------------------- 116 
1_pfamImport  81 IEQNagpag-----vpshLVIEAKEE-------------------------------VKVELSEENSGKLELDVQLKvIL 124 
XP_009024019 101 VLRNapp--------gysLAHSYRKEDDDNGG----------VNDSNVTSHDDQRAAVAATAAEDENRSVGW-------- 154 
Q7K4L9       123 IIPHlae--------kraIWQGIKRDQEIVRS----------LKDSYYYGIGPQTR--QNHETLKRYESILGKLGLPvRP 182  fruit fly
3_pfamImport  81 IINSfkrsvd--iseknsLLFSRFTKTYSPEVtiiianskvlQDNFYVHLLYFSCFFFFFYANEKEKLFSSTTKTNSiRG 158 
XP_016657149 115 IIRNfqhshaeptgtineLLEKSYEREYKIKRigmreknatlFNRFTKTNSPEKKGEVDIVQSTDE-------------- 180 
4_pfamImport  81 IIRNsqhshpeqtgtmneLLQKSYEREYKLKRmdmseenvtmFNHFTKTNSPEKKGDVDIEQSTEE-------------- 146 
XP_003373324  91 ITSGls----------kvLLVNYNPDTYQSPDesmlhnnsstFSYEFSNSPSLSVFRPSLYWSKEHPADVSTKPPEEvEL 160 
XP_003137694 126 VVRNlkrfn----ayqdrLLEKSYGKQ-SESNttvydlkrvlMKGPSALPKELQSRPKHYFRKRSDHWSSFLTAEDSlLS 200 
XP_003098362 134 VVRN--------------LEVLEEKENFISSYisdnshrtchFNPIDVFRFGPSVIPYSMK-ERQAAKARQMKIASPfRP 198 
XP_002125973 185 dhqskdktpntakleamrifglfdrkcpvlvdeyvedfklsilkklasvmphmtmvqtrdqdggsfiddefivgdnfetV 264  vase tunicate
EFX71033     166 DEIYFN--DTLTNNITNLDDERIDSL---LPTEvs----------------elDKIIRATVWPPEE-----YIVEFSLEY 219 
2_pfamImport 144 QAFITY--LLSVIRPHLLSDEEPSNYqieRTIDeqeeieftd---pleaeahlAYTEAMQDHDYADyk-yvYRVEYAVLF 217 
XP_002600544 117 -vPFPN--ATIQGLNENFENLSISAVeflRGDDnpvpqkglq--kvretvsefDMFKEA-VWPSDE-----YIVEYSLEY 185 
1_pfamImport 125 KTPGKT--VPLL---------EVMAR---------------------------------EAWPQGK-----YRVQYSLRY 155 
XP_009024019 155 --------SRMLSNLLALHDLSISSLtslIFNNvgnndgg-------dddngkVASDVGTIWPEDK-----YIVEYSLEY 214 
Q7K4L9       183 TFAYSN--ESLYYYFDAINILDTYDHpnaIQLK--------------------NEEDD-----EEQ-----YIVEYSLEY 230  fruit fly
3_pfamImport 159 VLGIDSilQSTRTNLSLIDDH--------------------------------------KVKLNEN-----YIVEYSLYE 195 
XP_016657149 181 --LIEN--KSGETNLFNYF----------------------------------------EVIFESD-----YIVEYSLEY 211 
4_pfamImport 147 --LVEN--KSGETNINLFNYLSFTDYtn------------------------------fEAILNSD-----YIVEYSLEH 187 
XP_003373324 161 YMPVSS--SEVN-----------------NNNHhnygdds-------iseefwLYPQEVEKNEEEP-----SAIEYAVEY 209 
XP_003137694 201 FFIRSD--SNLKKKLF-LEDLDDDELdfeSQDLi------------------dDSDASF------E-----YVVEYSLYY 248 
XP_003098362 199 MTYYSS--VLSFLRPNLFFDEEEe-----ETVKhydsveeleyqdpleaeahiAFYETMKDRPEPReyeylYRVEYAMLY 271 
XP_002125973 265 FSPFEP--SPIRSY---------------------------------------------------------YAIEYSSEF 285  vase tunicate
EFX71033     220 GFLRLSPT-TRRKLNITILLVTLDpVNNTCFGDSFGRFLLDEFLGYNDFIMGAVKALAEA-------EDSQGYLRNVVTG 291 
2_pfamImport 218 GLLRLPPD-YRELHNIPTTWVRID-AKSQCFGDKLSRLMMTFFVGYDEAVTSALRHQYSNmswnypdSYSMGYMHNILSH 295 
XP_002600544 186 GFLRLSPQ-TRQRLNIPIMVVTLDpTKDECFGDSFSRFLLEEFLGYDDILMSSIKGLAEH-------EDNKGYLRNVVSG 257 
1_pfamImport 156 GLLLPSSQkTPQGRSLPAMVVKLNpKRHLCFAEQVRSLVLGKFLNYVNVHMSHMKTLGEN-------EESKSFLSSVFSE 228 
XP_009024019 215 GFLRLTPN-TRQQLNISVKLVVLDpMKDECFGDQLSRFLLDEFLGYDDVLMSSVKQLAED-------ETNKGYLRNVVNG 286 
Q7K4L9       231 GHLRLSSS-TRKRLRIPVLTVQLDpNTDKCFGDSLTRYLLKRLLGYDDLLMASVRTIAEQ-------EENKGYLRNVITG 302  fruit fly
3_pfamImport 196 EYLILSPS-DRSQYGIPVMLVALDlTNNKCYGDSVSQFYLKYFLDYDHFMLWFVNSISEN----------KGFIRNVISG 264 
XP_016657149 212 GLLNLSPS-ARNRSSIPVMLVTLDpTLH--YNDSVSQFFLENFLGYDDLLFSCVKSLAEN-------EQNKGFFRNVISE 281 
4_pfamImport 188 RFLHLSPS-ARNRSSIPIMLVALDpTRNKCYRDSVIQFFLEYFFGYDELLLSSVKSLAEN-------EQNKGFFRNVISE 259 
XP_003373324 210 GFLRLSSA-TRDRLKIPIMYVALNpYQEVCFGESFNRFLLDHFFGYDFLLISSVKSLASN-------ESEKGYMRNLVTG 281 
XP_003137694 249 GLLKLPHS-YRLEHNIPFLLVRLDpEVDSCFGDWVSRTLMKNFIGYEDVLMSSVKALAEN-------ETDKGYLRDMITG 320 
XP_003098362 272 GVLRLPPD-FREEHGIPTTWIRID-SKSRCFGDQMSRLMMRLFVGYEDTIIAALRGQAYNlslvhpeTHSMGYLHNLQTH 349 
XP_002125973 286 GYLRLSSE-ARSVLAIPTLVVNLNpDKDQCFGSGLKKFMLETFLGYDDYLMTSIKKLAEK-------DNSQGYLRNLVTG 357  vase tunicate
EFX71033     292 EHYRFVNMW-MARTSYIASAFAMVIFTLSISMLLRYSRNQI------FIFIVDLLQM-LEFNINVTFPVASFFTVIL--- 360 
2_pfamImport 296 EHYSVVTTI-LGKSSYFIAALLMVIFTFAISMLLRFSHHQI------FVFIIDLLHM-FELQQPLNPPVAPLVTVVL--- 364 
XP_002600544 258 EHYRFVSMW-MARTSYIAAAFVMFMFTISVSMLLRYSHHQI------FVFIVDLLQM-LEMNVTIAFPAAPLLTVIL--- 326 
1_pfamImport 229 EFYPFVSIW-LARTCYLTAFVIMLIFTLSVSVLLRYSHYQI------FIFIVDLLQM-LEMNMTIAFPAAPLLTVIL--- 297 
XP_009024019 287 EHYRFVSIW-MAKSSYLAAAFIMVVFTLAVSMLLRYSHHQI------FVFIVDLLQM-LEMNRSLAFPAAPLLTVIL--- 355 
Q7K4L9       303 EHYRFVSMWwAAWSSYPAAFCVMLLFTFSVSMLLRYSHHQI------FVFIVDLLQM-LEYNVSARFPIAPLLTVIL--- 372  fruit fly
3_pfamImport 265 EHYNLGNIS-MDRMKYISSFLIM-AFDVYSCQQHRYKMRSTmelptpFLLSVQFCML-CTECSGQRLGLQPFIMSLLpgi 341 
XP_016657149 282 EYNRFDRMS-TSRMSYIASFFMMVVFTLLISMVIRYLQQQM------FVFFL-LVDLpLHFHRSVSFPVLPLLIAFL--- 350 
4_pfamImport 260 EYKRFDRMS-KPRTSYITSLLIMVVFTLLISKAMRYLQQQI------LLFIVFFRQRpVHR----SVPSLAMVLLMV--- 325 
XP_003373324 282 EQYRFVTMW-MSRSSYISAFLTMLTFTFSISALLRFSHQQF------FVFIINVFQL-FELNAAF-VQVAPLISVIL--- 349 
XP_003137694 321 EHYRFVTMG-NPRASYFTALIVMLIFTFAISMLLRFSHHQI------FLFIVDLLQM-FELNQALVFPAAPLLTVIL--- 389 
XP_003098362 350 DHYHFVANS-LGKWSYITAAVLMIIFTFAISMLLRFSHHQI------FVFIIDLLHM-FELQQPLNPPVAPLITVVL--- 418 
XP_002125973 358 EYFRFVTLW-VNHASVIIAFSAMIVFTLIVTMLLRYSYHQI------FMFMVEVLRL-LDTDTRLAFPAAPMLTIIL--- 426  vase tunicate
EFX71033     361 --ALV--GMEAIMAEFFNDSSTAFYVIIFVWVADQYDAVCCHTSVTKR 404 
2_pfamImport 365 --ALV--GMEAIMAEVFNDTSIAFYVILIVWVADQYDAICCHSAISKK 408 
XP_002600544 327 --ALV--GMEAIMSEFFNDTTTAFYIILMVWVADQYDAICCHTNISKR 370 
1_pfamImport 298 --ALV--SMEAVMSEFFNDTTTAFYIILIVWLADQYDAICCHTNTSKR 341 
XP_009024019 356 --ALV--GMEAIMSEFFSDTTTAFYIILIVWIADQYDAICCHTAVTKK 399 
Q7K4L9       373 --ALV--GMEAIMSEFFNDTTTAFYIILIVWIADQYDAICCHTSITKR 416  fruit fly
3_pfamImport 342 ceTLLafGVTVYMMSRFFNGPIMCYIQLIVILCDQYYNICSCCPITKR 389 
XP_016657149 351 --ALV--GIKVIMSELFNDRTTAFFVILIVYLADQYDTKCSRCPITKK 394 
4_pfamImport 326 --ALTrpGLKAIMSEIFNDGTTALYVISIVCLADQYVTNISHSPITKK 371 
XP_003373324 350 --GLV--GMEAVMSEFFNDTNIAFCVILMIWFADQYDFICCTSPLSRR 393 
XP_003137694 390 --ALV--GMEAIMSEVFNDTSTAFYVILLVWIADQYDAICCHSPISKR 433 
XP_003098362 419 --ALV--GMEAIMAEVFNDTSIAFYVILIVWVADQYDAICCHSPTSKK 462 
XP_002125973 427 --ALV--GMEEIMTEFFHDSTVAFYVILIIWAADQFDVICLHTMVGRR 470  vase tunicate
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