Conserved Protein Domain Family
Per1

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pfam04080: Per1 
Per1-like family
PER1 is required for GPI-phospholipase A2 activity and is involved in lipid remodelling of GPI-anchored proteins. PER1 is part of the CREST superfamily.
Statistics
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PSSM-Id: 461161
Aligned: 151 rows
Threshold Bit Score: 216.229
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KIS66800     137 PFILRITRWTCEDDCKYHCTHRITNDAAERVhkiqhdarievellaqsqplsasvkaerikgiiksklaelrpvqKQMVQ 216
XP_015640693  76 PLYMQWKQLNCMNDCRYYCMMQREGERQSRG--------------------------------------------LNPVK 111
XP_018676618  70 PLYLQWKQLNCRSDCRYYCMMQSEYQREKLG--------------------------------------------LGPAK 105
XP_009411454  69 PLYVQWKQCNCRSDCQYFCMMQQEKEREALG--------------------------------------------LKPVK 104
XP_002465979  76 PLYLQWKDWNCKSECRYHCMMERESERAKLG--------------------------------------------LQPVK 111
Q94EI5        71 PLYLRWKQWDCQSDCQYECMMTREEERKRNG--------------------------------------------ERPTK 106 thale cress
VDC63846      67 PLYLQWQKWGCQGDCRYHCMVNREKERETLG--------------------------------------------QPPLK 102
XP_002954799   1 PLSLRVFRWKCEDDCTYHCMRAVEAWKSTGGk-------------------------------------------GPIEK 37 
XP_002499669  83 dLGMKLTGWTCQTDCKYRCMHTLQTIRRSEG--------------------------------------------LPPAK 118
XP_003058154  95 daALRVLRWDCASDCKYRCMTAVERARRREG--------------------------------------------LEPKK 130
KIS66800     217 FHGKWVFIRFLGAQEPLSVLFSLLNFKIHWN-A--L-FMMRN--QLPDA--------SPLKLV-----------YIVH-- 269
XP_015640693 112 YHGKWPFIRVSVFQEPLSAALSAVNLLMHFT-G--W-LSFFL--LVNYK--------LPVRPQtkrtyyeytglWHIY-- 175
XP_018676618 106 YHGKWPFKRVFVFQEPLSAVLSAFNLLMHFI-G--W-LTFFI--LVSYK--------LPLRPQsrrtyyeytglWHIY-- 169
XP_009411454 105 YHGKWPFKRSSVLQEPVSAILSALTLVVQFN-G--W-LSFFL--LAYYK--------LPLRPHsgktyyeftclWHIY-- 168
XP_002465979 112 YHGKWPLKRASVFQEPLSASLSALTLVVQFN-G--W-LSFFL--LLYYK--------LPLRSEthktyyeytglWHIY-- 175
Q94EI5       107 YFGKWPLKHVYGIQEPVSVAFSALDLAMQFQ-G--W-VSYFI--LVYYK--------LPLQPnrktyy-eyngiVHIY-- 169 thale cress
VDC63846     103 YHGKWPFKRLLGIQEPASVAFSVLNLAMHFH-G--W-ISFFI--ALYYK--------LPLREdktayy-eyvglWHIY-- 165
XP_002954799  38 YYGKWPFLRVLGMQELASVLASLANLIAHAI----ClSRLLPlaEVPATgsscsrslYPFLWM-----------WTAY-- 100
XP_002499669 119 YYGKWSFTRVFGVQEIVSTLASLANMGVHLWfIpsVyAAARNrtSATSA--------GPCGSA-----------FARTwl 179
XP_003058154 131 YYGKWPFARVLGTQEIVSAVASVANGGAHAWrLptLtRAAKRrmRFAAL-------------------------WLGF-- 183
KIS66800     270 --TLISMNAWLWSAIFHTRDKNWTEKLDYFSAGSVVMSALFFSAARLf----------rLAPGSKRFvLLRRVCMAALAL 337
XP_015640693 176 --AILSMNAWFWSSIFHTRDIDLTEKLDYSSAVALLGYSLILSLLRTf----------nVKDEATRV-MFAAPILAFVTT 242
XP_018676618 170 --GLLSMNAWYWSAIFHTRDFDLTEKLDYSSAVAVLGYSFILSLLRIf----------nVKDEASRV-MFAAPILAFVTT 236
XP_009411454 169 --GLLSMNAWFWGAIFHTRGFDLTEKLDYSSSVALLGFSLILAVLRTf----------nVKNEASRV-MVAAPLLAFLTT 235
XP_002465979 176 --GLLAMNSWFWSAIYHSCDTTWTEKLYFSSAAAFLGYSLILTILRTl----------nLRDEASRV-MVAAPILAFVTT 242
Q94EI5       170 --AIIVMNSLFWSSICHSRDVELTERLDYSSATVLAGFSLILAILRSf----------sIQDQSVKI-MVTAPILAVVAT 236 thale cress
VDC63846     166 --GFLSMNSWFWSAVFHTRDVDITERLDYSSAIAVIGFSLIVSILRTf----------dVRVEAARV-MVSAPVLAFVTT 232
XP_002954799 101 --GCLHMNAWFWSAVFHSRDTRLTERLDYISAICLVAFGLFAAVARIlwgsmrrwhhfaA--------AATAAITAGLAA 170
XP_002499669 180 vnAAINANAWLWSAVFHSRDTRWTEFMDYTSANLLMFSALYCVLVRTf----------eLDNRRSA--GLFFAFFAWLVS 247
XP_003058154 184 --TLVNINAWIWSVLFHCRELPFTHYMDYLGVNIVFFYALYAAFVRAfeps----arraA--------ALAVAFVAAAVA 249
KIS66800     338 HVLYLSIG------RFDYAYNMAANVVIGLIHTLLWLMYSLrpttfpsnplvdrtaysraamratkpnlsvlstptplsn 411
XP_015640693 243 HILYLNFY------ELDYGWNMKVCVVMAVVQLLAWAIWAGi-------------------------------------- 278
XP_018676618 237 HILYLNFY------EMDYGWNMKVCLVMGVSQILMWVIWGGv-------------------------------------- 272
XP_009411454 236 HILYLNFY------ELDYGLNVKVCITMGIAQVLFWAVWAGi-------------------------------------- 271
XP_002465979 243 HILYLNFY------ELDKGLNMKVCTVISIAQCLLWALWAVm-------------------------------------- 278
Q94EI5       237 HILYLNFY------NLDEGLHWKVIFGIGGIELVVWGLWAAl-------------------------------------- 272 thale cress
VDC63846     233 HILYINFY------KLDYGWNMIVCVAMGVAQLLLWARWAAv-------------------------------------- 268
XP_002954799 171 HLYYMLYV------KFDYGWNMRVCVIAGIVTAALWLGWNA--------------------------------------- 205
XP_002499669 248 HVRMVNNPpdrsveSYRWEVNMRVMMTIAVAHWAIVLPWAYgcrlrrg---------------------------gfgsg 300
XP_003058154 250 HVRHVNPPr----qRYRYEYNMRAMFALIGAFWVVMLWWAFrgfrfrsrggg--------------------gggggggg 305
KIS66800     412 gaQtppvpvstniGPPNSHtrrrrRLQLILALMSASVLFELLDFAPILRILDAHALWHLATVPITKMWYDWLVNDA 487
XP_015640693 279 --T----------QHPSRF-----KLWVVVFGGALAMLLEVYDFPPYKGYADAHSLWHASTIPLTYLWWSFIKDDA 337
XP_018676618 273 --T----------RHPSRF-----KLWTAMIGCALAMLLEIYDFPPFHGYVDAHALWHATTIPLTYLWWSFIKDDA 331
XP_009411454 272 --T----------HHPSRF-----KIWAVVVGGAMAILLELYDFPPYKGYVDSHALWHATNIPLAYLWWSFVYEDA 330
XP_002465979 279 --T----------RHPSRL-----KIIFVSIGGAVAVLLEAYDIPPRWGYVDGRAICLAVAIPLSYLWWSFAKEDA 337
Q94EI5       273 --T----------SHPSKW-----KLRAFLISSILTLCLRMFDFPPYKGYIDAHALWRGAGIPLSYLWWSFVCDDA 331 thale cress
VDC63846     269 --S----------RHPSNW-----KLWMVVIASGLAMLLEIYDFPPYEGYFDAHSIWHAATIPLTVLWWSFIRDDA 327
XP_002954799 206 --W--------------TRhparyKMYVFMLLVHLSMLLEVLDFPPIGGLLDAHAAWHVATVVLTPLFYSWLHAD- 264
XP_002499669 301 nrRrlsh---pgrH----------SLALFAVLWHLAALAEVFDFPPIWGYLDSHALWHCGTPHCIWLWYRFLKEDL 363
XP_003058154 306 grGrgrh---pgrR----------WLLAFGATFHVAALGEVFDYPPAYHLVDSHAVWHCVTPGCIWFWYLFVKEDL 368
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