Conserved Protein Domain Family
DUF4778

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pfam16008: DUF4778 
Domain of unknown function (DUF4778)
This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 321 and 791 amino acids in length. There is a single completely conserved residue P that may be functionally important.
Statistics
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PSSM-Id: 435064
Aligned: 8 rows
Threshold Bit Score: 255.165
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDW37197      70 LTDKQRWFLINQSIIFALGKILGRPADVVSEFLYSLTLQNFSKVLNPVGHP--WSTCHVPLSNYDTCDYYMGIFDSQGNL 147
EDV94183      21 LSSWDLWYARNMKQIKRLASELNKPTREITELIYNLTLQKFNRLLNPRGMR--WNNCRVPFACPAVCDRYVDIFDLDGNV 98 
Q8IP16        35 SQEHCLWRQRNQMEIEQLAKLVGFQPDEIDGFLFNLSLRNYSDLLKYKECG--WNGCNVPLCYPYVCDRYMAIFDHRGNL 112 fruit fly
XP_001963320  46 sgaRRFWRERNDLVIQRMAKLLDCYPEEIGGFLHELTLQNYSRLLYPVGCG--RSPCNVPLCHPTVCDRYMGIFDEGGNL 123
XP_001988671  68 SSLKLRWHRTNRNIIMALARVLDIQADIVSDFLYTLSLQNFGQVLRPQGRQqlSSRCRVPLSDLDICDTYCSIFDGSGNL 147
XP_002051581  93 SSPRDYWFNANRGIILALSRAVGLHADVVSDFLYTLTMQNFAKVLNPRNSY--CYNCHVPLCTFDACDFNCGIFDSEGNV 170
XP_001965177  72 TDPKSRWFDVHKHIILSMAITLNRPPDVVLDFLYNLSMQNFRNILEPFRGYp-AGPCNVPFANGNICTQYMSIFDTRGNV 150
EDX05764      70 KSHKERWFLTNQRIILALATTLNRPPDLVSDFLHTLTLQNFSEILHPVETEtlGPSCKVPFVNCGACENFMRIFDTHGNV 149
EDW37197     148 RNPYHPESLKKLIQVMQSVLRERpd--------------------------------adNGAHDALFGDVIMRRRRGKNR 195
EDV94183      99 RDPANPWNLSKLLKLMQAILKLT------------------------------------DVNRINEPTNNAIRADLCRSK 142
Q8IP16       113 RSPIHARSLKSLLPLLLDYLNGDspndrkdspiyeaypdehqakcrsnieqsdleamssSDWISQLLGNPSESKREKTGK 192 fruit fly
XP_001963320 124 RDPTNPRSLFSLLYLLQRCLNGQplggcsglpinsnkkcgfeecyprtgpenyigldqeKVWQLYRFGNPKKRKRLRDQS 203
XP_001988671 148 RNPYHPESLLQLLTILQSVLKAGkelk-----------------------------esaNAAHGKLFGQESTQSKge--- 195
XP_002051581 171 RTPYQPESLLKLLSVLQLVLKGGke--------------------------------seNGAHKCLFGDAKCPARKFGLR 218
XP_001965177 151 RNPFHRNSLAMLIRMMQNVLS-----------------------------------------------NKQFRRHSPIDD 183
EDX05764     150 RSRLSQDSLQLLMEAVQTVLQ------------------------------------------------QSPPTELRALD 181
EDW37197     196 ---------------AKRAGIGPESAaqd----------rgqRRIQESNERAQELARNL--NRIGTHCDWHEHRERKPPE 248
EDV94183     143 krdgghmkierslkvASEQMPNSSAA----------------RRLKASKKEEDSKEEHVldAEIPTNGSPLNASSRVATP 206
Q8IP16       193 ktek--------pqpVMRSELESELEsesem-------ekkkRKNKTFGRQSVFLNDEL----ALAYAKSYDYAEYLMKT 253 fruit fly
XP_001963320 204 msfvpspsiistrvtVPRSSISSTYVsnmrvlksedsmedswRSRPGIKTTHTDPQMDPerNFEAELINIQ--------- 274
XP_001988671 196 -------------rlAHRAGIGEDSLarq----------ngrRRRYRLYAN--------------YLHDGFDTLFDVKKN 238
XP_002051581 219 ptrc-------tqkiADRSGIGPNSLarq----------nglRRRFTRYER--------------YYLDGND-------- 259
XP_001965177 184 ffvqphplrdraaerAKRAGIDSSSAarq----------ngrRRLREADFKAQENRRILynEMTDFLYHKPDVGSRFWEA 253
EDX05764     182 agfsgqrgaikrhsiARRAGIDRDSIarq----------ngrRRLRNSEARASENRSHL--NTGLEQRTAGDPGYVFGSS 249
EDW37197     249 YGIPCFGTPFGPPNAFGPGAGIltpdrgdpfglkgspwgrgglnggafgagRRLSEsfsisfdetlfkgpdgqvlqadqd 328
EDV94183     207 LNATSHGAYPMRVFGERAHRLLasdllltdrkg--------rrhghgspqlDNLRS------------------------ 254
Q8IP16       254 LGRHRFRDSYIGPVGD---------------------------------------------------------------- 269 fruit fly
XP_001963320     --------------------------------------------------------------------------------    
XP_001988671 239 FAAPFA------PNSEDLGYSRnpfiankrsnalaqdlgaadanlwlskypKELSHvdkfnnrfygnya----------- 301
XP_002051581 260 ------------PNAGKPGAGDaal-----------------------easTRRKHfdnmegyigyckgsia-------k 297
XP_001965177 254 VEPKTLQDFDLNDNEYGISSA--------------------------------FST------------------------ 277
EDX05764     250 LESAGLNA-MHTPEKWAFTDSL-----------------------------AL--------------------------- 272
EDW37197     329 gsgrgfsrdrrpgssPRGKELSSLIDGVNKktkltKDLGTLIDAVTGLDV---------EPKQQKDitks---------- 389
EDV94183     255 ---------------EQHRILNEIFRNLSR-----MDPERFLEALTGADLteedaklmkGEKVNVS-------------- 300
Q8IP16       270 ---------------LRTTRTHILIRDLIArkgmnINEKNLRKALKKVDLewkgttradYKREMKT-------------- 320 fruit fly
XP_001963320 275 ---------------RRASQIREIFNDFVEqqivhVDAVNLMEAIRLVDLgdlesesdeKRKGIGKvsa----------- 328
XP_001988671 302 --ayskslgdvgqgrRSGIHLRHLIRNVNAkvgigHDPSDLANAMGKLDL---------NEVQVNEanakampdayrgms 370
XP_002051581 298 atsglyagekliaysERRDYLRKLLNRIKDrvgieRNLDDLVVALTGFDL---------NKARESEmsrt---------- 358
XP_001965177 278 ---------------YQAEELTALIDLLNQrvlltRHLDDLLEAIKSLKLvdpavektgLSRVSAEri------------ 330
EDX05764     273 ---------------ERTRRLSKLLIQVNEktyltRDTEKLITAIKELNLdsnvtnpkkQPPRHSIm------------- 324
EDW37197     390 --------------------khlQRRLSDEYN 401
EDV94183     301 -----------------------VKDVSAFYT 309
Q8IP16       321 -----------------------AQEISRLYN 329 fruit fly
XP_001963320 329 --------------------nkiVDEISKFYN 340
XP_001988671 371 pgvrshmlppgkkwkmnshlyhgARTISHQYH 402
XP_002051581 359 --------------------rgiAQNISKEYN 370
XP_001965177 331 ----------------------yVKEISKSYN 340
EDX05764     325 -----------------------ANVISDSYY 333
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