Conserved Protein Domain Family
bHLH_TS_bHLHe22_bHLHb5
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cd18954: bHLH_TS_bHLHe22_bHLHb5 
basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 22 (bHLHe22) and similar proteins
bHLHe22, also termed Class B basic helix-loop-helix protein 5 (bHLHb5), or trinucleotide repeat-containing gene 20 protein, is an OLIG-related bHLH neural-specific transcriptional repressor that is expressed in both excitatory (unipolar brush cells) and inhibitory neurons (cartwheel cells) of the dorsal cochlear nucleus (DCN) during development. It is important for the proper development and/or survival of a number of neural cell types.
Links
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Statistics
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PSSM-Id: 381524
Aligned: 14 rows
Threshold Bit Score: 124.285
Created: 11-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #   # ### #    #                   ####                              
Q8NFJ8       243 LRLNINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQ 312 human
Q71T09       172 LRLNINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQ 241 chicken
Q0V9X5       154 LRLNINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQ 223 western clawed frog
XP_006005865 140 LRLNINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQALEEMRRLVAYLNQ 209 coelacanth
NP_523592    129 VRLNINARERRRMHDLNDALDELRSVIPYAHSPSVRKLSKIATLLLAKNYILMQQNALEELRRLLAYIQS 198 fruit fly
ELU13292     144 VRLGINARERRRMHDLNDALDELRSVIPYAHSPSVRKLSKIATLLLAKNYILMQANALEEMRRLISFMKQ 213 Capitella teleta
ADY39547     136 VRLCINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQANALEEMRRIIAYMNQ 205 Hottentotta judaicus
PVD23239     165 VRLNINSRERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQANALEEMRRLIIYLNQ 234 Pomacea canaliculata
XP_002591804  99 VRLGINARERRRMHDLNDALDELRSVIPYAHSPSVRKLSKIATLLLAKNYILMQANALEEMRRLVAYLNH 168 Florida lancelet
XP_011682018 130 IRLNINARERRRMHDLNDALDDLRGVIPYAHSPSVRKLSKIATLLLAKNYILMQANALEEMRRIFTFMNQ 199 purple sea urchin

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