Conserved Protein Domain Family
CCDC53

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pfam10152: CCDC53 
Subunit CCDC53 of WASH complex
CCDC53 is a component of the WASH complex, which plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting.
Statistics
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PSSM-Id: 462967
Aligned: 52 rows
Threshold Bit Score: 69.625
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAM38230      25 VNRFVISTVQFLNRFSDECESRLVQTEVSLQQLELQTQLLEHMlLSsgAadpDAVEEEEEGGErfDGnddgascledgdd 104
7_pfamImport   1 INNFVANTTRFLNHFAHECEERITRVSDNVTRVEILLAILEAK-LN--Si-pDLSVTDAEVAAaaTSddvrklnsnqmdl 76 
XP_002904730  46 INNFVANTTRFLNHFAHECEERITRVSDNVTRVEILLAILEAK-LN--Si-pDLNVSDAAVn---GDdgnlnlntnqmdl 118
EAX98312      35 INQFTERTVDFLNRFSNICDMKLLEVSQRINNIEILTKILESK-LE--Sv-kGLGFVPGQPLPpsSApspqag------- 103
EFA84223      42 VNNFVINTTQFLNRFNYLCEQKLTDVSNQLNRLEVTMSLLEIK-LG--Si-dGLESLPTANAPimTNtasgasssaappp 117
XP_004356907  22 VNNFVINTTQFLNRFSLLCEQKLVDVSNHLNRLEVTMSLLEIK-LG--Si-dGLESLPTANAPtyHTttntsgatapppp 97 
Q387Z1        22 VNKFVISTAQFLNRFAAYCESKLLETNRSLQRLETLTLLLEAK-IA--SvddELKETQPQTVEgqTTvkalgdnvarlmi 98  Trypanosoma brucei
CAM67251      36 VNRFVISTVQFLNRFSDECESRLVQTEESLQQLELQTQLLEHLlITssAadpEADEAEEEGGDhsNDddggasyladgdd 115
Q4DSA5        17 VNKFIISTTQFLNRFAAQCDSQLIEICRSLQRLEILTVLLENK-LK--SiddDFSEVNAATPStsAAafpqsasvgvggs 93  Trypanosoma cruzi
ERN06426      32 VNIFIVDTARFLNRFSALCEQKLADVHRRILRLDATLTLLEAK-LR--Si-dGIEEIKDGSRVkeRCfeytn-------- 99 
CAM38230     105 qdmmrdngsvasvaydyrqrhsrgggprafskksdvesvlglpaspsnnrrsggpppppgDYRKGPPRPPPGMSRAAAAA 184
7_pfamImport  77 gisdqdlpsvdtaaanemp---------lppppppaehvevvvdgmppppppssmdgfemALTVPRPPSPGALSLTDSMP 147
XP_002904730 119 gisdqdlpsmetngtplp------------ppppppevegaliegvlppphppsmdgmegALVLPPPPPP--SSPSGSMP 184
EAX98312     104 ------------------------------------------------------vppppaADGAPAPPPPPPPPGAGADG 129
EFA84223     118 ppgstttt-------------------------------ttannisnasappppppppgsISTNAAPPPPPPPPGSSAAA 166
XP_004356907  98 pt-------------------------------------------asspaapptsstasgGAPPPPPPPPPPGKGAAAAS 134
Q387Z1        99 pdrqvppp--------------------------------mpglspeggqrrlpppppshQNRKGPPPPPGSAAPAVKA- 145 Trypanosoma brucei
CAM67251     116 qdmvrddgseasaaydyrqrrgr--grrgasengdaesvlglpapppkdrrsggpppppgNYRKGPPRPPPGVARAAAAA 193
Q4DSA5        94 tplaivdrevp-------------------------ppmpgllsasgghhhppppppphlQRRNGPPPPPGVAIQTRVNG 148 Trypanosoma cruzi
ERN06426     100 -------------------------------------------------------gscssAERSHEPTYGSIMTLSESHA 124
CAM38230     185 QEAEAARAATLSIVGAPVLMPPLsaeapapppplelrpGRLLMRNHPRLRGYFQLLSLRVPKAFVKMKMQADGFQGEWLD 264
7_pfamImport 148 PPPPPSQGDFHAPPPDEVRVQSDg-------------pSMLKLKDDPVYAKYFTMRRLGIPDSVIEHKLMMDGMSTNILT 214
XP_002904730 185 PPPPSSMEDFDDDDEEAQVEVKEsd-----------glPVLKLKDDPVYAKYFTMRRLGIPEQVIEHKLLMDGMDTNILN 253
EAX98312     130 QAPPPPPPPDGAAPPAEGEAAAEgegqaaegenaepeaDPNDVRNDPRYAPYLKYLKIRVPLIAFRQKMIDEGLDPTLLE 209
EFA84223     167 PPPPPPPSSSSGSSSDSNS-------------------AAITYRDDPRYKPYFNLFAKGVPLVAFQGKMIADGLNPNAIL 227
XP_004356907 135 GPPPPPPPPSSSHQSDNEEEIIIvpta--------asnGGISYKEDPRYAPFFDLNRKGVPVVAFQSKMLALGLDPNAIS 206
Q387Z1       146 -------PPPPPVPLPPLMPGPPppgalpvqpppmplmGGVPMRSHPRLAGYYQMLALRVPAEVIKEKMRSDGYQPEWLD 218 Trypanosoma brucei
CAM67251     194 QEAEAARVATLAMVGAPVLMPQLsgdapapppplelrpGRLLMRNHPRLHGYFELLSLRVPAAFVKAKMQADGFQGEWLD 273
Q4DSA5       149 SAVVPIQPPPPVPPMPPSSLGQLpvgslppppppmpllGGFTMCTHPRLQGYFQMLALRVPVEAVKAKMQMDGHQPEWLD 228 Trypanosoma cruzi
ERN06426     125 PQQTPSTSVQPSTPSQ----------------------NQPPFDDDPRLARFCRMLHFGVPEQAVKMQMSIEGMDPSLLN 182
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