1E0B,5T1I,1DZ1,3Q6S,3I3C,3KUP,3P7J,3P7J,1E0B


Conserved Protein Domain Family
CSD

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cd00034: CSD 
Click on image for an interactive view with Cn3D
chromo shadow domain
The chromo shadow domain (CSD) is always found in association with a related N-terminal chromo (CHRromatin Organization MOdifier) domain. CSD domains have only been found in proteins that also possess a chromodomain, while chromodomains can exist in isolation. CSDs are found for example in Drosophila and human heterochromatin protein (HP1) and mammalian modifier 1 and modifier 2. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. The HP1 CSD, in addition to interacting with various proteins bearing the PXVXL motif, also interacts with a region of histone H3 that bears the similar PXXVXL motif. There are three human homologs of HP1 proteins: HP1alpha (also known as Cbx5), HP1beta (also known as Cbx1), and HP1gamma (also known as Cbx3). The CSD domains of all three human HP1 homologs have similar affinities to the PXXVXL motif of histone H3.
Statistics
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PSSM-Id: 349275
Aligned: 95 rows
Threshold Bit Score: 35.6494
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative binding pit [polypeptide binding site]
Evidence:
  • Comment:based on Schizosaccharomyces pombe Swi6; non-polar pit on the CSD dimer surface; binds a pentapeptide sequence of consensus PxVxL

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #                                          ### ##
1E0B_A      11 DLVSSIDTIERkddgTLEIYLTWKNG-----AISHHPSTITnkkCPQKMLQFYESHL 62   fission yeast
ODM95726    14 LAPEKIIGAHLdsngDKFFLVKWKNTs----RVDLLTNEEIkarCPALLIKYYESKI 66   Orchesella cincta
PCG67878   163 LAPEKILAGQLfh-gSLFFLVKWHGCt----DFDVVPGHELgeaYPDFVINYYESCA 214  tobacco budworm
NP_651093   85 LELAEIVGATDvt-gDIKYLVRWQFCd----EFDLVPSAQIvekDPQMLIDYFQKMA 136  fruit fly
KPU80150   319 LTIKEIICAFNrg-eDLLFLVKFKRCt----ELEVVSNEELknkAPNVLIKYYEEHV 370  Drosophila ananassae
CBY34949   246 LKPEKILGFCDdf-gDFAMLIKWKSTgs-ntFIDVVSADEVyekAPVFLCTYIESVI 300  Oikopleura dioica
CBY24230   212 LTFDELLGFHDdf-gEFEALIKWKKDgsgqtHCDLVPVDEIytkAPSIITDFMTTII 267  Oikopleura dioica
KFD56097   106 AEVEDIIEPKLgpdgHLFFCIKFFNKd----ETELVPKEVAykkYPREMIEFYERIL 158  pig whipworm
AAL05865   362 LDLDKILHCYQmn-dDLFMFVTWKGCs----SIDAVHINDIkeaYPLQIIKYFESLR 413  Drosophila melanogaster
CDS31968   231 TGEVTVYGVTTin-gNLMFIIHIAGVp----HPFLMTPNEAnvrYPDAVIQFYEKQL 282  Hymenolepis microstoma

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