Conserved Protein Domain Family
DUF2428

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pfam10350: DUF2428 
THADA/TRM732, DUF2428
This conserved domain is found in Thyroid adenoma-associated proteins (THADA) and the yeast homolog, TRM732. Trm732 forms a complex with the methyltransferase Trm7 to 2'- O-methylate tRNA residue 32 (Nm32), being required for Trm7 methylation activity. In humans, mutations of the Trm7 homolog FTSJ1, which interacts with THADA, impair Nm32 modifications, associated with non-syndromic X-linked intellectual disability. It has been suggested that these proteins may play a role in additional biological processes not related to translation. This domain contains a RRSAGLP conserved motif that is required for tRNA modification activity (Funk HM et.al., Preprint from bioRxiv, 03 Jun 2021 DOI: 10.1101/2021.06.03.446962).
Statistics
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PSSM-Id: 463054
Aligned: 137 rows
Threshold Bit Score: 84.7179
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004366355        1064 QMVADLIGLMFSVSKVVLRVVA--------DIAPEG----YTPKQEEGAAVNnNNnNdnslpkslpsgvlyddderlass 1131
8_pfamImport           1 RAMKQVFAAIHQSMGASLAVV---------GDATSGagdeNLSASFAGVVGEvSTvAetsssalrvdcr----------- 60  
Q16QQ7                60 KAFPGMLLLVNRVVEFVLRSFNc-------AKSKEE------------RQMIgSTfEim--------------------- 99   yellow...
EDS34118             301 KAFPKMLILVNRVVEFVLRSLNc-------AKTDEQ------------RLMVgSTfEim--------------------- 340 
EGI59842             714 QFTEKMLSLLKDAVEFFLSTFSikasntvySSSFAE------------MGL--AI-D----------------------- 755 
WGS:AAPU:GI23024-PA  640 ADVAELLPLLERILNVILKFLNlgnarqakTEASAA------------SFQD-MDeS----------------------- 683 
Q9VB48               636 tpledllplleRILSGILKFLNvanarrqeEAATAA------------SFQD-MDeS----------------------- 679  fruit fly
XP_001955346         645 QPLEDLLPILDRILKGVLQFLNlantrrkaEATTAA------------SFQD-MDeS----------------------- 688 
XP_002054740         641 AAVVELLPLLERILNVVLKFLNlanarrdgADETAA------------SFQD-MDeS----------------------- 684 
EDV95042             637 TSVAALLPPLERILNIILKFLNlans-qreQDAVAA------------SFQD-MDeS----------------------- 679 
XP_004366355        1132 fatlsaqtsiedileqigntagaagggENedddneevdekpQEqktsaavdilkgstgQIITVCAWLSMKELSLLLGAIL 1211
8_pfamImport          61 ---------------ghlivedggdhgDDdg--------gnTE---------------QRAVVGSWLAVRECGAIMELLM 102 
Q16QQ7               100 -------------------------dnSFqmll-----drsSQrstnl------sidkKTMLKALWKALHASAAFLENYA 143  yellow...
EDS34118             341 -------------------------dnSLqlll-----ersSQrstnl------aadkKTMMVAMWKALRSAGSFLENYA 384 
EGI59842             756 ----------------------------Ekik-------tsEIedfdyde-lqlspahQVLISCIWMSLKISCEIASEIG 799 
WGS:AAPU:GI23024-PA  684 ---------------------------LQllv------sesAYvvded-----deacrKYLLMSFWLTLKASCDLATSLA 725 
Q9VB48               680 ---------------------------LQllv------sesSFkcdge-----eeacrKYLLMSFWLTLKGCCDLATSIG 721  fruit fly
XP_001955346         689 ---------------------------LQllv------sesSFksgdd-----deacrKYLLMSFWLTLKGCCDVATTIG 730 
XP_002054740         685 ---------------------------LQllv------sesVYealed-----aeacrKYLLMSFWLTLKASCDLATSLG 726 
EDV95042             680 ---------------------------LQllv------sgsEYdereh-----aeacrKYLLMSFWLTLKACCDLSTSVG 721 
XP_004366355        1212 DGVSFPAKTAAEDSnnsssnnieLISVQqI-KDIGSAFLHILLNTRHKGAIEKAYLGFEILCSRLMGTTH---------- 1280
8_pfamImport         103 RRVPLPTSNPTSASv-------sLFTVD-MaQLGGETLLNSLFELKHKGAVATVYHAFEGVCRAFLAHGE---------- 164 
Q16QQ7               144 LWILDNYKTRLDTVk-------------qL-SICLRTFVMIMVNCCHRGAIEATGVAFGRVVKKICALKErlvvrndhrn 209  yellow...
EDS34118             385 MWTLDNYRNRLDTId-------------hL-SICLRAFIMMLLNCCHRGAIESAGVGFGRVIKKIAALKEclvvrndhrs 450 
EGI59842             800 MLIQSNAH---------------------V-KRSIDIIIMVLLKCRHKGVVECAGVTVANLSKCLYNEDKys-------- 849 
WGS:AAPU:GI23024-PA  726 CALLRSAPAGMLDCe-------------aL-QRCLDINVAVLTRCRHKGAIEAAGLSIGRLTRAITSTVA---------- 781 
Q9VB48               722 CYQLQTSAKTVNTEt--------------L-RRCLNINVSVLTLCRHKGAIEAAGLSIGRLTRAITSSLD---------- 776  fruit fly
XP_001955346         731 CILLETFQKTVNCAa--------------L-SRCLDINVSVLTLCRHKGAIEAAGLSIGRLTRSITSILD---------- 785 
XP_002054740         727 SALPRSTKSAP-DYa-------------aL-QRCLDINVAVLTRCRHKGAIEAAGLSIGKLTRTITGTLA---------- 781 
EDV95042             722 CALLREIDGQP-DYd-------------aL-QRCLEVNVAVLTRCRHKGAIEAAGLSIGRLTRAMTSRFA---------- 776 
XP_004366355        1281 PEly---tLPSSWIDQLFRRVR-EQSLNITRRSAGLPYTFTGLLAGESHHqkr----migPLLNQ-VLQSLLKLANGeeg 1351
8_pfamImport         165 -QsavlgnLPAQWADRLLDRLErSEQHFILRRSSGFAFSFVAILRAEPRNsaa-------viLPK-VMLTLLRLAGNdt- 234 
Q16QQ7               210 RQakliveLAERTFRTLIRL---DLQENDFRRCRGYLYMIHNFIKADLNNnaersylkiyIEVNRlPLCQPGMTT----- 281  yellow...
EDS34118             451 RQakriveLAERMFRALVRL---DLQESDFRRCRGYLWLIHNFIKSDSNTnaersylkiyIEMHRmPVNGMLVPA----- 522 
EGI59842             850 -------eLPKIYLTCLLEEDT-KKSLHLTRRGAGLSIMFHKLVVSDNRNnr--------ptVHF-AVETLLRSLK---- 908 
WGS:AAPU:GI23024-PA  782 SGdrafelLHDCLERELLSE---CRQVSTTRRGAGFSIMFLHVVKNDDPRqr--------slLHR-AVQRILERLNgsss 849 
Q9VB48               777 SCdsgfqmLHDCLERELLTE---SRQVSTTRRGAGFAIMFLHVLKNDNPRqr--------llLHR-AVQQILKRLN---- 840  fruit fly
XP_001955346         786 SSdagfqlLHECLERELLAD---SRQVSTTRRGAGFAIMFLHVLKNDNPQqr--------lvLHK-AVQQILKRLNsvtg 853 
XP_002054740         782 GEdqgfqlLHDCLERQLLSE---CRQVSTTRRGAGFAIMFLHVLKNDDPRqr--------llLHR-AVQRILERLN---- 845 
EDV95042             777 SEdrgfqlLHACLERQLLFE---CRQVSTTRRGAGFSIMFLHVLKNDDPRqr--------llLHR-IVQRILQRLNDgs- 843 
XP_004366355        1352 tvpspqdDgsiapeqwaeRNIYLPQVHSINILRSIFRNSSITNEVDSYFAQTLITIIKAYSSKSWS 1417
8_pfamImport         235 ------dAvdkcetheehHSQWRARVHALNILKLICQDGVLAEDVACYVVDMFQLSVRGFECGSWA 294 
Q16QQ7               282 ------------------EAIEKITVFQLHQLNLMVREATLNEKILEYIDDLMIIALERFKSTDWP 329  yellow fever mosquito
EDS34118             523 ------------------DALSRMSVLQLHQLNLMVREATMNETILEYIDDLMIIALERFKSPEWT 570 
EGI59842             909 -------NvsvttvrnieTGEDSPWAKRLHFLRALVADKEIHAQLGPYMEDICLTCFRYMESDVWT 967 
WGS:AAPU:GI23024-PA  850 d------------eaagsSNHDRWEALALHYLCVLVRDTELRPAMCKYYNEIMLVAIEHIDHTEWT 903 
Q9VB48               841 -------EnqtaetvcldSNHDRWEALVLHYLCVLVRDTELRPAMSKYYNEILLVAMEHITNPEWT 899  fruit fly
XP_001955346         854 a-------------aptdSNHDRWESLALHYLCVLVRDTELRPSMCKYYNEILLVAMEHIHNPEWT 906 
XP_002054740         846 -------GasnsdasnssSNHDRWEALALHYLCVLVRDTELRPAMCKYYDEIMLVAIAHIDNTEWT 904 
EDV95042             844 ------sAenaassnsssNNLDRWEALALHYLCVLVRDTELRPAMCKYYNEIMLVAMAHIDTEWTI 903 
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