Conserved Protein Domain Family
PGAP1

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pfam07819: PGAP1 
PGAP1-like protein
The sequences found in this family are similar to PGAP1. This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body.
Statistics
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PSSM-Id: 369540
Aligned: 19 rows
Threshold Bit Score: 157.911
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9LTZ8        109 KLSGVPVLFIPGNAGSYKQVRSVAAESDRAFQGgpfertfyqeasllrgggadtesVDYD-------------------- 168  thale cress
Q6C2Z2         73 EVGGRPVLFVPGNGGSMRQIRSIAGEAAVQYWHdprragadadtwangstarpksaLQKLntfafgdtesdtegvrglgd 152  Yarrowia lipo...
Q9KQA3         10 EGSGETVVLIHGLFGSLDNLGLLARDLKNDHQV-----------------------LSLD-------------------- 46   Vibrio cholerae
Q66J01         77 TLTGVPVLFLPGNAGSYKQARSFASVA-----------------------------LRKA-------------------- 107  African clawe...
Q75T13         82 PLTGIPVLFLPGNAGSYKQVRSIGSIA-----------------------------LRKA-------------------- 112  human
Q7PSQ5         76 LFTGAPVLFVPGSGGSYKQVRSLASVA-----------------------------LRKG-------------------- 106  Anopheles gam...
Q9W495         79 RMTGAPVIFVPGNAGSYKQVRSLASVA-----------------------------LRKA-------------------- 109  fruit fly
1_pfamImport    1 EAGQIPVLFIPGSQGSGKQIRSLASVM-----------------------------QNKT-------------------- 31  
XP_002636475   91 DINQIPVLFIPGSQGSAKQVRSIASVM-----------------------------QNKT-------------------- 121 
Q67TV0         79 NLNGVPVLFIPGNGGSYKQVRSLAAESFRAYQNgpleptfyre---astafsvnelEGFS-------------------- 135  Japanese rice
Q9LTZ8        169 ------------------------LPSQYSNR--LDWFAVDLEGEHSAMDGRILEEHTEYVVYAIHRILDQYkeshdtre 222  thale cress
Q6C2Z2        153 avtardmsgddrrdaverplsngkLPSQWPDDlpLDFFTVNFQEDLTAFDGTTVIDQAEYLNQAIAYILSLY-------- 224  Yarrowia lipo...
Q9KQA3         47 ------------------------LRNHG-----LSFHSDEHNYALMAQDVNQLLEHLNL-------------------- 77   Vibrio cholerae
Q66J01        108 ------------------------ENIGNRYH--FNIFTVNFNEELVALYGGSLRRQTRFVHECIKTILSLY-------- 153  African clawe...
Q75T13        113 ------------------------EDIDFKYH--FDFFSVNFNEELVALYGGSLQKQTKFVHECIKTILKLY-------- 158  human
Q7PSQ5        107 ------------------------LDNNWQAH--LDYFSVDLNEELSGVYGGYLQDQTDFLDLCIQEITRLY-------- 152  Anopheles gam...
Q9W495        110 ------------------------MSNDAGIH--LDYYTIDYDEELSALYGGYLHRQQSYLKLCIRTILSIY-------- 155  fruit fly
1_pfamImport   32 ------------------------EMRYAPFS--FRFFAVDFDEEMTFMNGHIVKRQIEYVMKAIRKIQSMM-------- 77  
XP_002636475  122 ------------------------EMRQSVFS--FRFFAVDFDEEKTFMNGHTVNRQLDYVMKAIRKIQSLM-------- 167 
Q67TV0        136 ------------------------IPSRYGRM--LDWFAVDLEGEHSAMDGRILEEHTEYVVYAIHRILDQYkeshlars 189  Japanese rice
Q9LTZ8        223 regaAASSKLPHDVILVGHSMGGFVARAAAVHPRLRKSAVQTILTLS-SPHQSPPLALQPSLGHYFAQVNREWKKG---- 297  thale cress
Q6C2Z2        225 ----SSHPNPPTSVIVIGHSMGGIVARTMVTLDSYIHGSINTILTLA-TPHVLPPVSFDKGIVGLYHNVNEFWKTE---- 295  Yarrowia lipo...
Q9KQA3         78 -----------TSVVVIGHSMGGKVA---MKLADIAAEKVRQLVVLDmSPVAYSQRRHD----NVFAGLEAV-------- 131  Vibrio cholerae
Q66J01        154 ----KNQTFPPESVAIIGHSMGGLVARALFTLKHFKPDLINVIITQA-TPHILPVLSTDIYLTDFYTMVNNYWI------ 222  African clawe...
Q75T13        159 ----KGQEFAPKSVAIIGHSMGGLVARALLTLKNFKHDLINLLITQA-TPHVAPVMPLDRFITDFYTTVNNYWILN---- 229  human
Q7PSQ5        153 -----GARGRTTRLFIVGHSVGGKLAQAVVGARTSIGRHVAGIVTLS-APVDKPVALFDHYHYSFYDRIEQAWRTN---- 222  Anopheles gam...
Q9W495        156 -----EGRTEQPSIVLIGHSMGGKLAQSVLVDPA-IGQHINTIISIS-TPLDQPVLNLDTQLEEFYDQTDAVLSKLrtat 228  fruit fly
1_pfamImport   78 --------RGNRKIVLVGHSYGGMIALLTTIYPEYQKD-VELIIVKG-APLNKQPLVNDWFSLRFNLLLVNQWNAL---- 143 
XP_002636475  168 --------RVKRRIVLIGHSYGGMVALLTTVHPDF-HDDIELVIVKG-APITKTPILNDWTTLRLNKLLTTKWDLL---- 233 
Q67TV0        190 kgraQSSDNLPSSVILVGHSMGGFVARAALVHPGLRKSAVETILTLS-SPHQYPPIALQPSLGQFFLHVNEEWRNG---- 264  Japanese rice
Q9LTZ8        298 -------------YEVQTSPGgnyv-sdplLSGVVVVSISGGYNDYQVRSKLESLDGIVPSSHGFMISSTSMTNVWLSME 363  thale cress
Q6C2Z2        296 -------------TVPGGK-----------LEDTLLVSVTGGIRDQMIPAEYSSVDTFLPPTNGFAVATTSIPDVWMSID 351  Yarrowia lipo...
Q9KQA3        132 -----------------------------------LVQKPTSRSEVMAILAQHIEQEGVRQFLGKSLMS----------E 166  Vibrio cholerae
Q66J01        223 -------------YNSLK------------LRNITMLSVAGGYSDYQVRSGLTFLPTSSFHTSALSVVSSAVPITWASTD 277  African clawe...
Q75T13        230 -------------ARHI---------------NLTTLSVAGGFRDYQVRSGLTFLPKLSHHTSALSVVSSAVPKTWVSTD 281  human
Q7PSQ5        223 -------------RSLAGAANaspshgllpLDGILFVTIGGGIRDIIVHDGLTA-----SRYADLHAMTHNIPNVWLSVD 284  Anopheles gam...
Q9W495        229 vptmttnvcdslhQRPPSVQRmasqdssarLDNVLLISTGGGNRDLLVRPGLTS-----SRFNDLHAMTSAIPKVSLSCD 303  fruit fly
1_pfamImport  144 -------------QNNN-------------LSHVGVVAYSGGIRDYMIPDEWSILRNVT---NRPLWAIDGVSDL--GAD 192 
XP_002636475  234 -------------QASD-------------LKHVGVVAYTGGLRDFQIPDEWSIMRNVT---HRPIWAVGGVSDL--GAD 282 
Q67TV0        265 -------------YKTGLSRTss-----akLSNVVVVSVAGGIHDYQVRSKLALLDGIVPSTHGFMVGSSSMKNVWLSME 326  Japanese rice
Q9LTZ8        364 HQAILWCNQLVVQVSHTLLSM 384  thale cress
Q6C2Z2        352 HQAMVWCHQLRRVVAETLLVV 372  Yarrowia lipolytica CLIB122
Q9KQA3        167 QNVMTW----RFNVAALKAHY 183  Vibrio cholerae
Q66J01        278 HLSIVWCRELVLVTARALFDL 298  African clawed frog
Q75T13        282 HLSIVWCKQLQLTTVRAFFDL 302  human
Q7PSQ5        285 HLCAMWCLQFVLVMNRFLFSM 305  Anopheles gambiae str. PEST
Q9W495        304 HLSAVWCLQFMQAINRFLFSV 324  fruit fly
1_pfamImport  193 HLAILWCNEFVRHVSRVLWSY 213 
XP_002636475  283 HLAILWCNEFVRHVSRVLYFY 303 
Q67TV0        327 HQSILWCNQLVVQVAHTLLSM 347  Japanese rice
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