1NKP


Conserved Protein Domain Family
bHLHzip_Myc

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cd11400: bHLHzip_Myc 
Click on image for an interactive view with Cn3D
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family
The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).
Statistics
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PSSM-Id: 381406
Aligned: 38 rows
Threshold Bit Score: 85.2908
Created: 19-May-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLHzip mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Structure:1NKP; Homo sapiens bHLHzip c-Myc transcription factor basic region binds the DNA, contacts at 4.0 A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ##  ## ### ##   #                   ##                                          
1NKP_A         6 KRRTHNVLERQRRNELKRSFFALRDQIPELenneKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQL 85  human
XP_024886050 586 KRRNHNCLERQRRADLRKVYDDLRKNIPAVasnpKAAKVDILKYGRAHVIELIRLQKAYKRESDKSERLKQKRMVLYNMK 665 Temnothorax cur...
EGI58462     189 RRRLHNNMERQRRINMKESYEQLRKQVPAVaendRASKVSILKQGAACIKFLTETGNSLKTNIKQLKEHNQVLKRKLQHL 268 Panamanian leaf...
XP_022905365 409 KRKLHNHMERKRRIDLATAFSSLKKVVPKIekkdKASKINILKEAADYCHFLTNKSLVQQREKLRLQAETHSLEQRLRQL 488 Onthophagus taurus
AKG92752     376 KRNLHNNMERQRRIDLRNAFEDLRVLVPEVskkeRAAKVVILREAAQYCDNLTTISNNLHRTSEELNRKQAWLRWRVSEL 455 Colorado potato...
XP_011337645 474 KRNLHNNMERQRRIDLRLQFEKLRDLVPAIasklKTPKVAILTQADYLFTTLDIKKQKLSIEESKLKIDKDNLLKKFRRH 553 clonal raider ant
XP_014213212 482 KRNQHNTMERKRRIHLRGMFEELRRIVPELshqkFAAKIKILSSSAKYCYQLQCAERNYVKHRAELGLYQLNLNSRLEKL 561 Copidosoma flor...
PSN56635     123 KRNQHNNMERLRRIDLREAIASLRKIVPAVakndRAPKVLVLKEATKYIDYLDSTENHLASLANKLAAEQERLSFKLKEL 202 German cockroach
XP_014472360 220 RRDLHNRMEKERRITLKNLFDNLREEVPNIksnsRTSKVAILTEATEYIKELRKLEKMMEEGMRNVIKEKRLLRAKLMEH 299 Dinoponera quad...
EDQ87345     304 QRDAHNAMERERRVQLRENFEALRAEVPSLrdadKAATLQILREATAYIKRIRDEEKQLLEEKAQLIAINDSLRKKATVV 383 Monosiga brevic...

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