Conserved Protein Domain Family
PWWP_PWWP2A
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cd20152: PWWP_PWWP2A 
PWWP domain found in PWWP domain-containing protein 2A (PWWP2A)
PWWP2A is a H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. It is also required for proper mitosis progression. PWWP2A and its paralog PWWP2B form a stable complex with NuRD subunits MTA1/2/3:HDAC1/2:RBBP4/7, but not with MBD2/3, p66alpha/beta, and CHD3/4. The PWWP domain specifically recognizes DNA and histone methylated lysines.
Links
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Statistics
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PSSM-Id: 438980
Aligned: 8 rows
Threshold Bit Score: 203.702
Created: 9-Jan-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Feature 1:putative methyl-histone binding site [polypeptide binding site]
Evidence:
  • Comment:the aromatic residues form the three-walled methyl-lysine cage that directly participate in histone methylated lysine binding and recognition.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                         #  #                         #                  
Q96N64        634 KMKVFSKNVSkcvtpDGRTICVGDIVWAKIYGFPWWPARILTITVSRKDnGLLVRQEARISWFGSPTTSFLALSQLSPFL 713  human
F7AQ22        663 KIKMFSKNVSkcvtpDGRTICVGDIVWAKIYGFPWWPARILAITVSRKDtGLLVRQEARISWFGSPTTSFLALSQLTPFL 742  tropical claw...
KGL84177      334 KMKVFSKNVSkcvtpDGRTICVGDIVWAKIYGFPWWPARILTITVSRKDnGLLVRQEARISWFGSPTTSFLALSQLSPFL 413  white-throate...
XP_006002651  722 KVKVFSKNVSkcitpDGRTICVGDIVWAKIYGFPWWPARILTITVSRKDnGLLVRQEARISWFGSPTTSFLALSQLSPFL 801  coelacanth
XP_007903751  510 KVKIFTKNVSkcvtaDGKTICVGDIVWAKIYGFPWWPARILTITVSRKDnGLLVRQEARISWFGSPTTSFLALSQVSPFL 589  elephant shark
ROL48039      881 KAAVFSKNVTkcvalDGRTICVGDIVWAKILGFPWWPARILAITVSRKDnGLLVRQEARVSWFGSPTTSFLAITQLAPFL 960  Anabarilius g...
A0A1L8GR68    663 KIKMFSKNVSkcvtpDGRTICVGDIVWAKIYGFPWWPARILAITISRKDnGLLIRQEARISWFGSPTTSFLALSQLAPFL 742  African clawe...
XP_030217194  743 PGEGRSRSGRrc--gAERGVCVGDIVWAKISGFPWWPAQVLALSVGGGG-GARREEEARVAWFGSPTTSFLPVAQLAPFL 819  Atlantic cod

Feature 1                                                   
Q96N64        714 ENFQsRFNKKRKGLYRKAITEAAKAAKQLTPEVRALLTQFET 755  human
F7AQ22        743 ENFQsRFNKKRKGLYRKAITEAAKAAKQLTPEVRALLTQFET 784  tropical clawed frog
KGL84177      414 ENFQlRFNKKRKGLYRKAITEAAKAAKQLTPEVRALLTQFET 455  white-throated tinamou
XP_006002651  802 ENFQlRFNKKRKGLYRKAITEAARAAKQLTPEVRALLTQFET 843  coelacanth
XP_007903751  590 ENFQsRFNKKRKGLYRKAITEAAKAAKQLTPEVRSLLTQFET 631  elephant shark
ROL48039      961 ENFQsRFDKKRKGLYRKAITEAAKAAKQLTPEVRALLTQFET 1002 Anabarilius grahami
A0A1L8GR68    743 ENFQsRFNKKRKGLYRKAITEAAKAAKQLTPEVRALLTQFET 784  African clawed frog
XP_030217194  820 ESFQsRFDRKRRGPYRRAVTEAARAATPLPPGVRSLLTQLEA 861  Atlantic cod

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