Conserved Protein Domain Family
DUF4683

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pfam15735: DUF4683 
Domain of unknown function (DUF4683)
This domain family is found in eukaryotes, and is typically between 384 and 400 amino acids in length.
Statistics
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PSSM-Id: 464832
Aligned: 8 rows
Threshold Bit Score: 411.954
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004083662  739 VNPQKEEMGQETEEGDVGELKIRYEDYQENKTEKTIVA-QQEAHYKFFPSVILSNCLSRrk--agNKKPVD---NQELSp 812 
XP_022282161  675 NRTMVHSLDSIADESGLNKLKIRYEEFQEHKTEKPSLS-QQAAHYMFFPSVVLSNCLSR------PQKLSPvtyKLQPS- 746 
XP_016152928  337 SRTVVHSLENNTDEGGLNKLKIRYEEFQEHKAEKPSLS-QQAAHYMFFPSVVLSNCLSR------PQKLAPvtyKLQQG- 408 
XP_008119348  737 PSTVIHSSENTTGGDSLNNLKIRYEEFHEYKAQKTNMN-QQAPHYMFFPSVVLSNCLSQ------PQRLGPvtyKLQQG- 808 
XP_005990939  778 ERSTVSAGESSTDEGSFGKLRIRYENFQEYKSEITSFS-QQETHYKFFPSVVLSNCLDR------SEKVISlpcKLQQV- 849 
XP_010713657  290 VDNYMFDDDDSTLGSDVCSLKIRYESFQDNVREKTTAL-QEDAQFNFFPSV-FGNCTKRdsr-stLKRGPGgatDPSQFk 366 
XP_003412764  291 VDNYMFDDDESTLGSDVCSLKIRYESFQDNVRDKTTLLmQEDAQFNFFPSV-FTTCPKResksgaLKQs----sDLSQFk 365 
XP_002665692  717 lGPEESEMGQGTKEDDVGELKIRYEDYQENKADRTIVA-QQEAHYKFFPSVILSNCLARpikkqaGSKIGEvscTLDQPe 795 
XP_004083662  813 SRRSKLKTSKKRlgMAGH--RNKTKLSHDSTST---GTSnLTSSSLHsVTVETEELVDQP--TVEAQSIGDEPMVIVKke 885 
XP_022282161  747 SKQSRLKINKKK--LIGH--QETSTKTSETVSTk--DNC-IQNNPCN-SNPEKDNVLASDl-IKVTRGAFENKTPIDS-- 815 
XP_016152928  409 NKQSRLKLNKKKhsFINR--QQPAS-VNDVASVk--EGCyTQGNACS-NIPDKDSALPSDl-VQVPLEAFENKMPTSTan 481 
XP_008119348  809 RKQSRLKLTKKKv-LLSS--QQPTN-VCDNPFTe--ESCyIQGNASN-NIPDKDSSLPNDneVQVPHGAFENKMSMGTsn 881 
XP_005990939  850 DRHSRLKLKKKKlnLVSQnaKEPVL-ANDKADGs--AIAfTQPNACSsNISEESRPLSPN----LAHDNDTSVASVTPan 922 
XP_010713657  367 -SEEGIIWGEEEedGEEEdgEEEEK------------------AALNkSCNSTEVVQYVG---------PKRSHFLDSvn 418 
XP_003412764  366 VPDVSIIWGEEDknLDKK--KDKEEGQEDKDVEkkdRKEnGEKPALNkPCSETEVEHFKN---------SKQGQLIn--- 431 
XP_002665692  796 QRKSRLKLTKKKptLDQK--RELPVKTHS--PTkeePPAlLSITPGShNQNEVSKEVDMEtsGSLIESSGKGDFADIPtn 871 
XP_004083662  886 Y--DESRVNKPM---EPASELlvsnstiitassevpkdfkeqilspdedlaakvtctkpSALPGSKYSLRAKRKTVCDGE 960 
XP_022282161  816 F--IDCHFGDGT---LETEQS--------------------------------------FGLYGNKYTLRAKRKVNYETE 852 
XP_016152928  482 Y--TDCQFADGS---LETEQS--------------------------------------FGLCGNKYTLRTKRKVNYETE 518 
XP_008119348  882 C--VDCHFEDGA---QESYQA--------------------------------------FGLCGNKYTLRAKRKINYETE 918 
XP_005990939  923 R--LSLHIEEESplqLDSEKA--------------------------------------FSSCGSKYTLRTKRKINYETE 962 
XP_010713657  419 SteDSGEFSDDStctESSYDVlrdikdcs----------------------rylsrdhsSSFIQQNYGLRAKRKVRYSDD 476 
XP_003412764  432 SleASVNFSDDSsfiEVSYDAmgeikdcsr--------------------ymardtnsgSSSSQQNYGLRAKRKVRYSED 491 
XP_002665692  872 I---------------SCTKV--------------------------------------ASLPGSKYTLRTKRKRIYEKG 898 
XP_004083662  961 -----DGEHSGPTQSKISSSVKKRLKETNVAGGLhvKDQKKRK---KEPPIIIKYIIINRFKGQKNMLVKISRMKSGEQS 1032
XP_022282161  853 -----DSESSFVTHNSKISLPHSMEIGESLDGTL--KSRKRRKmskKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQ 925 
XP_016152928  519 -----DSESSFVAHNSKINLPQPIESVESLDGSQ--KSRKRRKlskKLPPVIIKYIIINRFRGRKNMLVKLGKVDSSEER 591 
XP_008119348  919 -----DSESSFGAHHSKINLPHSVGNDECLDGSK--KCQKRRKlakKLPPVIIKYIIINRFRGRKNMLVKLGKIDSSEEQ 991 
XP_005990939  963 -----DSESSLGSQNSRTSHLQFRTSTQNPDNSQ--QHWKRKKi--REPPVIIKYIIVNRFKGRKNMLVKIGKVDSKEDS 1033
XP_010713657  477 ylydvDSIENEKILDKKEWLPDGPKEEDDDEWCP----KKRRKvsrKEPPVIIKYIIINRFKGEKHMLVKLSKVDANETT 552 
XP_003412764  492 ylydvDSLEGEKINERKEWLPGGSKEEDDDEWCP----KKRRKvtrKEPPVIIKYIIINRFKGEKNMLVKLGKVDASETT 567 
XP_002665692  899 -----DHPRSGSSK-------QASVHHDDPKGSDhvFSQKKRKvtkKEPPVIIKYIIINRFKGQKNMLVKISKVSSDETH 966 
XP_004083662 1033 VQLTPDKLEQYNKLAPLKDFWPKVPESP--AVEFPVIELKAKKT------------PKRKVKVNSTNKKTPqkGLNNTSK 1098
XP_022282161  926 VILTEEKMELYKKLAPLKDFWPKVPDSP--ATKYPIYPLTPKKS------------HRRKSKHKSAKKKTG--KQQRTNS 989 
XP_016152928  592 VVLTEEKMNLYKKLAPLKDFWPKVPDSP--ATKYPIYPLTPKKS------------HKRKAKHKSTKKKAG--KPQKTGS 655 
XP_008119348  992 VILTEEKMNLYKKLAPLKEFWPKVPDSP--ATKYPVYPLTPKKG------------QKRKAKCKSTKKKIG--KLHNINS 1055
XP_005990939 1034 VTLNEHRMETYKKLAPLKDFWPKVPDSL--ATKYPVYPLTPKKI------------QKKKTKAKPSLKKKCk-NLRNVDG 1098
XP_010713657  553 VTLNEELLSKYEKLAPLKGFWQERQQSR---LDLLRSSLYHKQNfylngsdasflpHPRKRKCKLANRHRIq-RIKAIEQ 628 
XP_003412764  568 VNLSENQLNKYSKLAPLKGFWQKKKKQRnnNTDSIKISLCQKQSfepgsfevsflsPARKRKSKHGNRHRIq-RIPSMEA 646 
XP_002665692  967 TVLTPEKLAGYEQLAPLKKFWPKIPEST--AEKYPSLEPKVKKC------------PKRKAKINPVVKRMT--TFPKSKC 1030
XP_004083662 1099 HWLKRGRGVKRAKGCQrgpvlpSLPPPRPCYCELTDDRDNDYKDVMVELGYLSDTSLSPAESTPPRCWSPSD 1170
XP_022282161  990 ENIKRTLSFRRKRSHA------ILSPPSPSYNAETEDCDLNYSDVMSKLGFLSERSTSPINSSPPRCWSPTD 1055
XP_016152928  656 TNIKRTLSF-RKRTHT------ILSPPSPSYSAEAEDCDYNYSDVMSKLGFLSERSTSPVNTSPPRCWSPTD 720 
XP_008119348 1056 KNIKRSLYF-RRRPHA------FLSPPLPSYNTEAEDCDLNYSDVMSKLGFLSERSASPVSVSPPRCWSPTD 1120
XP_005990939 1099 KNTERTVPSKRKISSFs-----TLSPPLPCYTAEAEDCSPEYTDVMYKLGFLTERSPSPDKPSPPRCWSPSD 1165
XP_010713657  629 SVNKLGSC--------------SSDHKQPCS--SKEDAGL-------------KGL-QALAIATPSCANGLH 670 
XP_003412764  647 STSSKQVSF-------------CNDQKQTN---RKEDGCL-------------KGTLKPTALTTPSCTNGLH 689 
XP_002665692 1031 PRVGQTRGERRAKAMLpv---qTLAPPWPSYNDFTDDTCTEYCDVMMKLGYLSERAPSPTDSTPPRCWSPTE 1099
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