Conserved Protein Domain Family
VAD1-2

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pfam15310: VAD1-2 
Vitamin A-deficiency (VAD) rat model signalling
VAD1-2 is a family of proteins found in eukaryotes. The family is expressed in testes and is involved in signalling during spermatogenesis.
Statistics
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PSSM-Id: 464635
Aligned: 28 rows
Threshold Bit Score: 156.059
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KAB1265184   143 EDDQ-VSTNHRSIRVQTSKHLFWADKLIQASEHSLQKAIStqpQPVKKS-------------------TdettshlDQQS 202
XP_016049183  72 EEEP-MSANHRSISIQTSRHLFWADKLLQASEHSLDRVLL---QFNNKS-------------------K-------DKTL 121
XP_012887384 170 EEDQ-VLIQRRSIHAQTSRHLFWSDKNVQASENSLQKVIEi--QDKGSS-------------------KkttrshpEKKS 227
Q8C5V0       107 EEE--MGGRYRSIPVQTSKHLFWSNKLIQASEHSLQKALEk--------------------------------------- 145 house mouse
EGW08210      55 EELVcTSTHFRSIRVQTSKHLFWSNKLTQASELSFQKVks---------------------------------------- 94 
ELK14197     164 LEDQ-EFTYQRSIHVQTSKHLFWADKFIQASEYNLKQETSr--QPGKKN-------------------TdktksrpKQGS 221
XP_023602058 239 DEEQ-VDSTHRSIFVQTSKHLFWADKDVQASEYSLDLETGm--QRGESTekiasppnqkavpepnqkaVpe----pNQKA 311 little brown bat
XP_023409532 123 QEEQ-MSTSYRSICAQTSNHLFWADKNIQASEHSPTPAIGl--EPRKNV-------------------Tnmlt------- 173 African savanna...
XP_023366953 145 EESQ-VFTEHRSIRVQTSKHLFWANKLIQASEHSLQKEINv--HLKKSG-------------------GdkttshlGQNF 202 small-eared galago
XP_021082631 163 EERVcTVTHFRSIPVQTSKHLFWSNKLIQASEHSLQQALEk--------------------------------------- 203 golden hamster
KAB1265184   203 VPKGTMCskeqLQDPSAQPALP-------------------ATGSQ------PSSS---PATIGLADLINFASSLAMASS 254
XP_016049183 122 VPKNNLC----LISPTTQSAHT-------------------DTQSQksppycLPPSq--PSTISLAELINFASSLAMASS 176
XP_012887384 228 ISIAT-------------PTLP-------------------AACSQkppvssSLPVshlSPPIALSDLINFASSLAIAST 275
Q8C5V0       146 ------HhrspQEKSISISQVY-------------------TECTQppssppVSRPt-tPTAIGLADLINFASSLAVASS 199 house mouse
EGW08210      95 ----------pREKYVSISQVL-------------------TECAPrplgssRSCTs-lPAALGLADLINFASSLAVASS 144
ELK14197     222 VPKNTPCskeqLQNPSIQPDLP-------------------DTVSDqppsapPPSPt-lQPSLGLEDLINFASSLAVASS 281
XP_023602058 312 VPE--PVpvkqFQDESTQAELP-------------------EPGTRqpsdtdVPSPy-lTPAINLQDLVNFASSLAIASS 369 little brown bat
XP_023409532 174 -----------------ssrAGqenvpndalscraqgaystTSSQTlltspsLSSSs-lPAAIGLADLINFASSLVMASS 235 African savanna...
XP_023366953 203 IHTNTPSsknqVQTSSAHSDHP-------------------ATGSQvppsthLSSSs-lSPAIGLAELINFASSLAMASS 262 small-eared galago
XP_021082631 204 -----RCkspqEKKCVSISQVL-------------------TDCAPgppsphMSCTs-lPTAIDLADLINFASSLAVASS 258 golden hamster
KAB1265184   255 SKMDLPNLEHMVKAPPQ-------KATEPPTEP--------TMDEPEQEKLTNE---LLEKPPek------------plE 304
XP_016049183 177 NNMDLPSLENMFKMSIQ-------KVIKPSAGPtvnhvpqpSVDQPKQEKPSRE---APKEPPkkspeeltekplnktlE 246
XP_012887384 276 SNMNLPSLEKMLKPVLQ-------KAPEASTKPsq-----pAEEKQELTGKL---------------------------K 316
Q8C5V0       200 SNMALPNLENMIKGTSE-------KSQNTSLDFcqpvqaikFAQATQITQISSE---KQDESP----------------K 253 house mouse
EGW08210     145 SSMNMPNLENIIKGSSE-------KSQETSREFcqpgqsvkFSQTTQITQMSSE---KQEKKP----------------E 198
ELK14197     282 NKMDLPSLEHMIKTPPQ-------KAMEPSTEPmvedasqpAKDKPEQEKLS-E---LPKESPek------------plE 338
XP_023602058 370 SNRDLPNLEQMMKSPPQ-------KAVEPSTVPtvesttppAKEEPEQEKLPEVqerASEKSL----------------E 426 little brown bat
XP_023409532 236 SK-DLPNLEHLIKAPSQ-------KAVEPSTEPakdpaaqpTRADLELEKPAEV---PTEKPSek------------paE 292 African savanna...
XP_023366953 263 SKMNLPNLEHIIKAQSQkteepstEPIQPSTEPvq-----pSTETQEEIPPEKP--------P----------------E 313 small-eared galago
XP_021082631 259 SNMNLPNLGNMIKGTSE-------KSQETSIELcqpgqsikFAQATQITQTSFE---KQEKSP----------------K 312 golden hamster
KAB1265184   305 AGELQKALKQKDKSFPHPYLDVSKQGFKsANIEGEVKFLQPPNMSPQLQEAVKelpqkpqrlltrDpgEEQtGRMQKGRL 384
XP_016049183 247 SGEFQKTWQEGNKNFLYPYLDFSKPGMK-ATIKGEMKLLQPLDLSPPPQEVKD------------N--SVP-ETRKGNPL 310
XP_012887384 317 TVKFQKTWAKQETNFPHPFLEFSKPGMKtATLEGEVKFVQTSTMNS--QESQD------------D--SVPpGTKKGSPL 380
Q8C5V0       254 SMA-HKSWTRETRNVACSYLDINQAGLKtATIQGEVKFVQTPIASPQLQEAKE------------D--SVP-GTKKGNPL 317 house mouse
EGW08210     199 NMTTHKSWTPETRNVACSYINFSKTGLKnHTIQGEVKFVQAPTTSPQLQGAKEeppqkprslltrDirEEQaGRVHKGRL 278
ELK14197     339 AEEPHRAQKLEHKNF----FDYRKPGIQkTTIQGQLKLLQSPAVSPPQQGDEK------------KppQKPkRQLTRDPE 402
XP_023602058 427 AGEPLEPAKQEDKTL-HPYFDFSKPEPQrTAFKGKVKFIRAPARSSSLNGDRK------------D--SVP-GTKKETPL 490 little brown bat
XP_023409532 293 AGEPQKVWNEGDKSFPGACLGFNNLGIKrATIEGEVKFLQPPTLALPPQGARK------------D--SVP-GTKKGSPL 357 African savanna...
XP_023366953 314 DGEPQKTWNQEDKNLPRSYLDFSKLGAKrATIEGEMKLLQPPAIPPPLQGARK------------D--SVP-GTKKGNPL 378 small-eared galago
XP_021082631 313 DMTSHKSWTQETENIACSYLDFSKTGLKnATIQGEVQFVQAPVPSPQLQGAKE------------D--SVP-GTKKGNPL 377 golden hamster
KAB1265184   385 QQRAALltqtEPAAATAPGA 404
XP_016049183 311 LLKIHF----KLSTPSIPEK 326
XP_012887384 381 LLKIHF----KLLSPELQRN 396
Q8C5V0       318 LLKIHF----KLSSPQPQRN 333 house mouse
EGW08210     279 RLQTDQlsqsELEATMATKE 298
ELK14197     403 EGKGDRtqkgRLQQHTAPLT 422
XP_023602058 491 MLKIHF----KLLPTSSPRE 506 little brown bat
XP_023409532 358 LLKIHF----KLSSPSSPTE 373 African savanna elephant
XP_023366953 379 LLKIHF----KVSSPSIPEK 394 small-eared galago
XP_021082631 378 LLKIHF----KLSSPSPPEK 393 golden hamster
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