Conserved Protein Domain Family
FH_FOXL2
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cd20028: FH_FOXL2 
Forkhead (FH) domain found in Forkhead box protein L2 (FOXL2) and similar proteins
FOXL2 is a transcriptional regulator that is essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Mutations in the FOXL2 gene cause blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) types I and II, a rare genetic disorder. In BPES type I, a complex eyelid malformation is associated with premature ovarian failure (POF), whereas in BPES type II, the eyelid defect occurs as an isolated entity. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410802
Aligned: 19 rows
Threshold Bit Score: 169.164
Created: 17-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #                 ##  #                      ## ##  #      #           ### 
P58012        54 KPPYSYVALIAMAIRESaeKRLTLSGIYQYIIAKFPFYEk----nKKGWQNSIRHNLSLNECFIKVPREGGGe--RKGNY 127 human
NP_001038717  46 KPPYSYVALIAMAIRESseKRLTLSGIYQYIISKFPFYEk----nKKGWQNSIRHNLSLNECFIKVPREGGGe--RKGNY 119 zebrafish
AAO12874       1 KPPYSYVALIAMAIRESaeKRLTLSGIYQYIISKFPFYEk----nKKGWQNSIRHNLSLNECFIKVPREGGGe--RKGNY 74  chicken
ELU18532       1 KPPYSYVALIAMAIKDSgdKRLTLSGIYAYIMKKFPYFEk----nKKGWQNSIRHNLSLNECFVKVPREGGGe--RKGNY 74  Capitella teleta
BAE06446      51 KPPYSYVALIAMAIRDSneKKLTLSGIYQYIVDKFPFYEk----nRKGWQNSIRHDLSLNECFVKVPREGGGe--RKGNF 124 vase tunicate
EFN76749      69 KPPFSYVALIAMAIQHSaqKRATLSEIYAYITAKFPYFEk----nKKGWQNSIRHNLSLNECFVKVPREGGGe--RKGNF 142 Jerdon's jumpin...
EFX88524       1 KPPYSYVALIAMAIKESreKRLTLSEIYNYITKKFPYYEk----nKKGWQNSIRHNLSLNECFVKIPREGNAtgdRKGNY 76  common water flea
XP_013404097 149 KPPYSYVALITMAIKESgeKKLTLNGIYQYIVNKFPYYQnlstkkQKGWQNSIRHNLSLNECFLKIPREGGGe--RKGNY 226 Lingula anatina
CAE51212      37 KPPYSYVALIAMSIAKSpdKRLTLSGIYQYIMDNFPYYAk----nKKGWQNSIRHNLSLNECFVKVPKEGGD---RKGNY 109 Suberites domun...
ABB89483     168 KPPFSYVALIAMAIKDSpeRKLTLSQIYQYIINKFSYYEk----nKKGWQNSIRHNLSLNECFLKIAREGGGg-eKKGNY 242 purple sea urchin

Feature 1        #              
P58012       128 WTLDPaCEDMFEKGN 142 human
NP_001038717 120 WTLDPaCEDMFEKGN 134 zebrafish
AAO12874      75 WTLDPaCEDMFEKGN 89  chicken
ELU18532      75 WSLDPsMRFEDMFEK 89  Capitella teleta
BAE06446     125 WMLDSnCEDMFENGN 139 vase tunicate
EFN76749     143 WTLDPqYEDMFENGN 157 Jerdon's jumping ant
EFX88524      77 WTLDPqYEDMFENGN 91  common water flea
XP_013404097 227 WALDPaFEDMFEAGN 241 Lingula anatina
CAE51212     110 WTLDEsCEEMFEKGN 124 Suberites domuncula
ABB89483     243 WTLDPaYDDMFEKGN 257 purple sea urchin

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