Conserved Protein Domain Family
7tmA_OR6C-like

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cd15912: 7tmA_OR6C-like 
olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320578
Aligned: 99 rows
Threshold Bit Score: 368.735
Created: 23-Jul-2014
Updated: 17-Oct-2022
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

cd15912 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd15912 is a member of the superfamily cl28897
cd15912 Sequence Cluster
Sub-family Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
Q96RD1        23 VVIFVFLLITYMLSITGNLTLITITLLDSHlqtpMYFFLRNFSILEISFTTVSIPKFLGNIisgdKTISFnnCIVQLFFF 102 human
Q8NH79        23 TPLFIAIFLTYILTLAGNGLIIATVWAEPRlqipMYFFLCNLSFLEIWYTTTVIPKLLGTFvvarTVICMscCLLQAFFH 102 human
XP_008174424  25 TSLFMVVLLMYILTIVGNVLIIVIVIRDPClhtpMYFFLGNLSFLEIWYITTLVPKMLANFlaqkRSISLrcCLTQAFFH 104 western painted...
XP_006038311  23 SVLFSVVLLMYILTILGNGLIVFIVRATHKlhtpMYFFLSNLSFLEIWYTTTVVPKMLETFvatkATICIycCLVQAFFY 102 Chinese alligator
XP_006037496  25 FVLFLVVLLLYLLSLIGNGLIIIMVRVDRRlqtpMYSFLSNLSFLEIWYTTAIIPKMLANLlstkTTICFycCMAQGYFH 104 Chinese alligator
XP_006277757  25 KVLFVFILFIYILTLAGNGLIIAIVRTDQQlqtpMYFFLSNLSFLEIWYTTTIVPKMLETFlvarTTICLncCLVQSFFH 104 American alligator
XP_007442719  25 KYLFVPILFIYLLTIIGNILIIIIVVHDPHlhhpMYFFLGNFSSLEIFYVTTLSPKMLAHFlaekKSICFycCITQAFFH 104 Burmese python
XP_005312334  23 MMFFGVILFMYLSTLVGNSLIITVVWTDQKlhtpMYFFLCNLSLLEIWSTTLVVPKMLANLlsdrTTICFscCMAQVFLH 102 western painted...
XP_007444827  23 VGFYILLLLMYLLSLMGHSLIITVVSMEPRlhtpMYFFLLNFSMAEICSTAAEIPKMLVNSfsgkKTICFacCMAQGFVV 102 Burmese python
ETE59621     313 GLMYAGIFFLYLLCLMGNGLIIVMVILDPHlqkpMYLFLSNLSFIDIGHTTTFIPKLLVNYlcakNSICFncCMTQMFFY 392 king cobra
Feature 1        #  #                                            # #####                         
Q96RD1       103 ILLGVTEFYLLAAMSYDRYVAICKPlhCLSIMnRRVCTLLVFTSWLVSFLIIFPALMLllkLHYCRSnIIDHFTCDYFPL 182 human
Q8NH79       103 FFVGTTEFLILTIMSFDRYLTICNPlhHPTIMtSKLCLQLALSSWVVGFTIVFCQTMLliqLPFCGNnVISHFYCDVGPS 182 human
XP_008174424 105 FFLGATEFFLLAAMSFDRYLAVCDPlhYGAVMsNGLCLWLALGSWLGGFLTVFLQTILvcqLPFCGPnLINHFYCDVAPL 184 western painted...
XP_006038311 103 FFLGSTEFFILTVMSFDRYLAICKPlqYATLMtNRVCFQLAFGAWFGGFMAIFFQTILvfqLPFCDSnVINHFYCDIGPI 182 Chinese alligator
XP_006037496 105 FLFGITEFFILTVMSFDRYLAICHPlrYTVLMtMRVCFQLSLGVWVGGFLSIFLQTFLvlqLPFCCSnVINHYYCDIGPL 184 Chinese alligator
XP_006277757 105 FFLGITEFLILTVMSFDRYVAICKPlhYTSIMtHQNCSLLVMGAWTLGFVVIFSQAVLllqVPFCARnVINHFYCDIGPI 184 American alligator
XP_007442719 105 FFLGATEFCLLASMSFDRYIAICNPlhYSVIMnYRLCLQLALGSWLGGFFTVIVQTVLlcqLPFCGPnLINHFYCDVTPL 184 Burmese python
XP_005312334 103 FSLGTTESVILMSMSFDRYLAICRPlhHATIMtIRVCFRLAFLGWLGGIVLIFFHSLPvwiLPFCRDnRVDHFYCDLGPL 182 western painted...
XP_007444827 103 FTMGAVEFITLTIMSFDRYMAICKPlhYQTIMtSGLCLNLSLLAWLGGIGIIFPQSIVvwtYPYCERnIIDHFFCDVGPV 182 Burmese python
ETE59621     393 FFFGVTEYFIITLISVDRYLAICHPlrYATIMtSGICLKLAIASWFAGFFSILYQTIIipnLPYCTSnIINHFYCDVGPV 472 king cobra
Feature 1                  #  ### ### ##                                            #  ## ##  #  
Q96RD1       183 LQLACSDtkfLEVMGFSCAAFTLMFTLALIFLSYIYIIRTILripstSQRTKAFSTCSSHMVVVSISYGSCIFMYIKPsa 262 human
Q8NH79       183 LKAACIDtsiLELLGVIATILVIPGSLLFNMISYIYILSAILripsaTGHQKTFSTCASHLTVVSLLYGAVLFMYLRPta 262 human
XP_008174424 185 LKLACADtrfIEQVVFTVAALVLLSSFSFTTIWYVFIISAVLripsnSGRQRAFSTCASHLTVVSILYGTVIFMYVRPkv 264 western painted...
XP_006038311 183 LKIACTDthlIELLGFVAAVTVILSSLLFTVVSYIYIIATILaipssTGRRKAFSTCASHLIVVSILYGAVLFMYLRPnv 262 Chinese alligator
XP_006037496 185 LKVACGDtqlIQSLGFIVAVSVILSSFVFTVVSYIFIIVTILqipssKGRQKAFSTCTSHLTVVSILYGAVFFMYLRPta 264 Chinese alligator
XP_006277757 185 LKLACADtrtIELLGFLGSITIIPSTLLFTVVSYFYIITTIVripsaGGRRKAFSTCASHFTVVSILYGAVVFMYLKPta 264 American alligator
XP_007442719 185 LNLVCADtylLEQMVLLGSALLLFSSFLLTAISYAFIISTIMrisssSGRQKAFSTCVAHLTVVSIQYGTVMFMYVKPka 264 Burmese python
XP_005312334 183 LKLACADtsiIEFTGFITTVILQGSAFLFTLISYIFIISTIIqipssTDQKKAFSTGAAHLTVVNIFYGALIFMYMRPst 262 western painted...
XP_007444827 183 LQLACADtrvIELIGFLYGATIMWGSFGFSLISYMRIISTIVqipsaSGRSKAFVTCASHLTVVTIFYTADMLMYLKPst 262 Burmese python
ETE59621     473 LKIAGGDiqiIELIGILITVVVVMSSMISSLISYLFIIFTILrmpstIRQQRAFSTCASHLIVVCMLYGSVLFVYLRPtv 552 king cobra
Feature 1            ## ###  #  ##              
Q96RD1       263 -kdRVSLSKGVAILNTSVAPMMNPFIYSLRN 292 human
Q8NH79       263 -hsSFKINKVVSVLNTILTPLLNPFIYTIRN 292 human
XP_008174424 265 -nsSLELNKVVSVLNTVITPLLNPFIYTLRN 294 western painted turtle
XP_006038311 263 -hsSSGLNKVVSVLNTVLTPLLNPFIYTIRN 292 Chinese alligator
XP_006037496 265 hqsSFSLNKAVSVLNTVLTPMLNPFIYTLRN 295 Chinese alligator
XP_006277757 265 -hsSFSLNKVVSVLNTLLTPLLNPFIYTIRN 294 American alligator
XP_007442719 265 -nsSLEINKVVSVLNTIVTPLLNPFIYTLRN 294 Burmese python
XP_005312334 263 -hsSFRINKVVSLLNTVLVPVLDPFIYTIRN 292 western painted turtle
XP_007444827 263 -hgDTRLNKAVSLVRTSFIPMLNPFIYTIRN 292 Burmese python
ETE59621     553 knsSFSRMKTVSLMNTIVVPMLNPFIYTIRN 583 king cobra

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