Conserved Protein Domain Family
7tmA_OR10G6-like

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cd15942: 7tmA_OR10G6-like 
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320608
Aligned: 6 rows
Threshold Bit Score: 446.109
Created: 12-Dec-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
Q8NH81        46 APLFLAFLVIYLLTVSGNGLIILTVLVDIRlhrpMCLFLCHLSFLDMTISCAIVPKMLAGFllgSRIISFggCVIQLFSF 125 human
XP_007443693  25 APLFLFFVCVYLLTLLSNFLVFLATIYEPQlhkpMYWFLCHLAIADIATSTTVVPKMIASFlqgNKVISFagCITQLFVY 104 Burmese python
XP_007439435  25 IPLLFFFSIMFILTLSGNSLIILVVISDLQlhkpMYWFLCHLSILDMAFSAVVVPKVIAGFipgGKVISFvgCVTQLFFF 104 Burmese python
XP_007443697  25 TPLFLFFLLVYFLSITGNILILLTVASKSDlhkpMYWFLCNLAIMDIAVSTVVVPKVMDGFvegGRIISFggCLTQLFFY 104 Burmese python
XP_005312053  25 IPLFLFFLIIYLLTLYGNLLILLVVARERRlhkpMYWFLCHLSFLDMTVSSVVVPKVVAGFlsgGRAISFqgCVAQLFFF 104 western painted...
XP_007439436  25 LPLLLFFSVMFALTLAGNSLIILVVISDLQlhkpMYWFLCHLSLLDMAFSSVVVPKVIAGFnsrGKIISFteCVTQIFFL 104 Burmese python
Feature 1        #  #                                            # #####                         
Q8NH81       126 HFLGCTECFLYTLMAYDRFLAICKPlhYATIMtHRVCNSLALGTWLGGTIHSLFQTSFvFRLPFCGPNRVDYIfCDIPAM 205 human
XP_007443693 105 HFVGCAECFLYTVMAYDRFLAICWPlhYSILMnHKICLWLSVGTWFGGCLHSAIETALtFHLPYGPGNEVSYIfCDIPAM 184 Burmese python
XP_007439435 105 HFLGCAESLLYTLMAYDRFLAICKPlhYGNIMnWKACLSLSLGTIIGGCLQSTFQTFLtFHLPYGQKNNIDYVfCDIPAM 184 Burmese python
XP_007443697 105 HFLSCSEFFLYTVMAYDRFLAICKPlhYNTIMnHRMCFCLSLGTWLGGCLHSIMVTSLsYGLPYGPKNEVNFIlCEILSV 184 Burmese python
XP_005312053 105 HFLGCTECFLYTVMGYDRFLAICKPlhYSIIMnHRACLCLAVVTWLAGSLHSTIQTALtFQLPYGQENRVRYIfCDIPAV 184 western painted...
XP_007439436 105 NFLGCAESLLYTLMAYDRFLAICKPlhYGNIMsWKACLILSLGTIIGGCLNSTFQTTFtFRLPYGQRNSIDYVfCDIPAI 184 Burmese python
Feature 1                  #  ### ### ##                                            #  ## ##  #  
Q8NH81       206 LRLACADtaiNELVTFADIGFLALTCFMLILTSYGYIVAAILripsaDGRRNAFSTCAAHLTVVIVYYVPCTFIYLRPcs 285 human
XP_007443693 185 LKLACVDtsfNEMFTLIDVGLVAMSCVLLILVSYVYIIFAILkirngDGQRHAFSTCTSHIILVITFYIPLTFTYLRPga 264 Burmese python
XP_007439435 185 LKLACVDtkfNELVSFIDVGLVAMTCFLLILASYVYIIIAILrisssEGQRRAFSTCTAHITVVVIYYLPVVYHYMRPss 264 Burmese python
XP_007443697 185 LKLACSDtwfQEIFTLVDIGLVAIFCIFFIVMSYMYIVSAILkipsvEGQHRAFSTCTSHLIVVMICYVPAAFNYLRTgt 264 Burmese python
XP_005312053 185 LKLACRDtalNELVTFVDIGFLAFTCFLLILMSYVYIVSAILrihsaKGRRRAFSTCMAHVTMVVTYYVPEFFIYLRPgs 264 western painted...
XP_007439436 185 LKLACADtelNELMIFIDIGLVAMTCFLLILASYAYIVIAILkisssEGRHRAFSTCSAHLTVVVIYYLPLFYRYMRPss 264 Burmese python
Feature 1         ## ###  #  ##                     
Q8NH81       286 QEPLDGVVAVFYTVITPLLNSIIYTLCNkEMKAAL 320 human
XP_007443693 265 EDPLGGVVAIFYTTVTPLLNPVIYTLRNkEMKYAV 299 Burmese python
XP_007439435 265 QDSMDGVVSVFYTTVTPLLNPVIYTLRNkEMKNAL 299 Burmese python
XP_007443697 265 LDLLSGVIALFYTTWTPFLNPLIYTLRNkEMKDAM 299 Burmese python
XP_005312053 265 WHPLDGVVAVFYTTVTPLLNPLIYTLRNkEMKDAL 299 western painted turtle
XP_007439436 265 QDSMDGVVSMFYTTITPLLNPVIYTLRNkEMKTAL 299 Burmese python

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