Conserved Protein Domain Family
7tmA_OR4A-like

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cd15939: 7tmA_OR4A-like 
olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320605
Aligned: 33 rows
Threshold Bit Score: 369.234
Created: 12-Dec-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

cd15939 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd15939 is a member of the superfamily cl28897
cd15939 Sequence Cluster
Sub-family Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
Q8NH83        23 KALFVMFLLTYLVTVVGNLLIVVDIIASPSLgsPMYFFLACLSFIDAAYSTTISPKLIVGLFcdKKTISFqGCMGQLFID 102 human
Q8NH49        23 RVISVMFLLMYTAVVLGNGLIVVTILASKVLtsPMYFFLSYLSFVEICYCSVMAPKLIFDSFikRKVISLkGCLTQMFSL 102 human
Q8NGF9        17 RVCFVIFLFLYTAIVLGNFLIVLTVMTSRSLgsPMYFFLSYLSFMEICYSSATAPKLISDLLaeRKVISWwGCMAQLFFL 96  human
Q8NGL7        23 VLCFVLFLFCYIAIWMGNLLIMISITCTQLIhqPMYFFLNYLSLSDLCYTSTVTPKLMVDLLaeRKTISYnNCMIQLFTT 102 human
NP_001000647  23 VFCFLFFSFCYLAILSGNLMILISVRCSSLFnqPMYYFLSHLSSMDICYTSCVTPKLIGDLLvrRKYISFtNCMLQVIAM 102 Norway rat
Q6IEV9        23 KIVFVIFLIFYMGTVVGNMLIIVTIKSSRTLgsPMYFFLFYLSFADSCFSTSTAPRLIVDALseKKIITYnECMTQVFAL 102 human
NP_001000638  23 LLFFLLFLLCYLAVLMGNSVILVTISCSHLIeqPMYYFLCHLSLMDLCYTSTLIPRLIRDLAatRKNISYnECMTQLFTA 102 Norway rat
NP_001000925  22 AICAVLFLLCYLAILCGNLIVLLTIKGSQLSeqPMYFFLSYLSFMDVCFTSTVAPKFIIGLLvqCNTISYnACIAQMFYA 101 Norway rat
XP_001520072  23 VICFGLFLLLYVGIVMGNLLIFLTIQFSHLIsqPMYYFLRSLSLVDLCYASTISPKLITDLMveRRTISFpNCMTQLFAS 102 platypus
XP_007664773  23 IFCFGLFLSCYVTILLGNLIILITVRGSSLIkqPMYFFLSHLSLMDVCYTSTVTPKLVRDLLseKKTISFgHCMMQLFTM 102 platypus
Feature 1        #  #                                            # #####                         
Q8NH83       103 HFFGGAEVFLLVVMACDRYVAICKPLhYLTIMnRQVCFLLLVVAMIGGFVHSAFQIVVYs-LPFCGPNVIVHFSCDMHPL 181 human
Q8NH49       103 HFFGGTEAFLLMVMAYDRYVAICKPLhYMAIMnQRMCGLLVRIAWGGGLLHSVGQTFLIfqLPFCGPNIMDHYFCDVHPV 182 human
Q8NGF9        97 HFFGGTEIFLLTVMAYDHYVAICKPLsYTTIMnWQVCTVLVGIAWVGGFMHSFAQILLIfhLLFCGPNVINHYFCDLVPL 176 human
Q8NGL7       103 HFFGGIEIFILTGMAYDRYVAICKPLhYTIIMsRQKCNTIIIVCCTGGFIHSASQFLLTifVPFCGPNEIDHYFCDVYPL 182 human
NP_001000647 103 HFFGLIEVLILAAMAFDRCVAICKPLhYMLIMsRSKCHVLILVSWVGGAAHSFSQFCLLicLPFCGTNEIDHYYCDIFPL 182 Norway rat
Q6IEV9       103 HLFGCMEIFVLILMAVDRYVAICKPLrYPTIMsQQVCIILIVLAWIGSLIHSTAQIILAlrLPFCGPYLIDHYCCDLQPL 182 human
NP_001000638 103 HLLAGVEIFILVSMALDRYVAIVKPLhYMVIMrRKRCDMLIVTAWVLGFWHSIALLLMVlsLPFCGPNHINHYFCDVKPL 182 Norway rat
NP_001000925 102 HFFGATEIFILVVMAYDRYVAICRPLyYMITMsRQVCYILVIGSVFGAFIHSLVHVLVIirLPFCGTNEIDHYFCDIFPL 181 Norway rat
XP_001520072 103 HFFGGVEIFILVWMAYDRFVAICKPLhYTVIMnRRACNGMLLLACVVAFVHSMAQLLLTlqLPFCGPNQIDHFFCDVNPL 182 platypus
XP_007664773 103 HLFGGVEIFILVGMAYDRYVAICKPLhYMVIMnKQRCATVVGVCWGGGILHSMVQWLLIifLPFCGPNKIDHYFCDVYPL 182 platypus
Feature 1                  #  ### ### ##                                           #  ## ##  #   
Q8NH83       182 LELACtdtyfIGLTVVVNSGAICMVIFNLLLISYGVILSSLktysqEKRGKALSTCSSGSTVVVLFFVPCIFIYVRPvsN 261 human
Q8NH49       183 LELACadtffISLLIITNGGSISVVSFFVLMASYLIILHFLrshnlEGQHKALSTCASHVTVVDLFFIPCSLVYIRPcvT 262 human
Q8NGF9       177 LKLACsdtflIGLLIVANGGTLSVISFGVLLASYMVILLHLrtwssEGWCKALSTCGSHFAVVILFFGPCVFNSLRPstT 256 human
Q8NGL7       183 LKLACsnihmIGLLVIANSGLIALVTFVVLLLSYVFILYTIraysaERRSKALATCSSHVIVVVLFFAPALFIYIRPvtT 262 human
NP_001000647 183 LKVACtdttiAGILVVANSGLIALVTFVLLFGSYVVILFTLrnysaEGRHKALSTCGSHITVVILFFGPCIFAYLRPptT 262 Norway rat
Q6IEV9       183 LKLACmdtymINLLLVSNSGAICSSSFMILIISYIVILHSLrnhsaKGKKKALSACTSHIIVVILFFGPCIFIYTRPptT 262 human
NP_001000638 183 LKLVCkdihvVNILSIVNSGVVVVAIFIVLLASYILILYSLrtrssAGQRKALSTCSSHIMVVVLFFGPCIYIYILPagN 262 Norway rat
NP_001000925 182 LKLACtetrlLVIVIITTTGVMSILTFVALVISYIIILSILrtrssEGRRKALSTCGSHITVVFMFFLPLIFTYVPMgdS 261 Norway rat
XP_001520072 183 LKLACtdtyvVGLLVMANTGMIAMLTFVVLLISYIVILVSLrthspHSRRKALATCGSHITVVVLFFGPCIFIYVRPatT 262 platypus
XP_007664773 183 LELACsdtdvTGFLVLANSGTIVLVSFAVLVFSYITILASLrtrslEGRRKALSTCASHITVVALFFLPCIFIYLRPaqT 262 platypus
Feature 1        ## ###  #  ##              
Q8NH83       262 FPTDKFMTVFYTIITHMLSPLIYTLRN 288 human
Q8NH49       263 LPADKIVAVFYTVVTPLLNPVIYSFRN 289 human
Q8NGF9       257 LPIDKMVAVFYTVITAILNPVIYSLRN 283 human
Q8NGL7       263 FSEDKVFALFYTIIAPMFNPLIYTLRN 289 human
NP_001000647 263 FPEDKIFALFYTIIAPMFNPLIYTLRN 289 Norway rat
Q6IEV9       263 FPMDKMVAVFYTIGTPFLNPLIYTLRN 289 human
NP_001000638 263 ENKDKEISVFYTVIAPMLNPLIYTLRN 289 Norway rat
NP_001000925 262 VGDDKVFALFYTMIAPLFNPLIYTLRN 288 Norway rat
XP_001520072 263 FMADKVLAVFYTIVVPMFNPLIYTLRN 289 platypus
XP_007664773 263 FPEDKVFALFYTIIAPMFNPLIYTLRN 289 platypus

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