Conserved Protein Domain Family
Amelin

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pfam05111: Amelin 
Ameloblastin precursor (Amelin)
This family consists of several mammalian Ameloblastin precursor (Amelin) proteins. Matrix proteins of tooth enamel consist mainly of amelogenin but also of non-amelogenin proteins, which, although their volumetric percentage is low, have an important role in enamel mineralization. One of the non-amelogenin proteins is ameloblastin, also known as amelin and sheathlin. Ameloblastin (AMBN) is one of the enamel sheath proteins which is though to have a role in determining the prismatic structure of growing enamel crystals.
Statistics
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PSSM-Id: 461551
Aligned: 9 rows
Threshold Bit Score: 565.207
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_018880683  11 MKDLILILCLLEMSFAVPFFpQQSG----T-PGMASLSLETMRQLGSlqrLNTLSQYSRYGFGKSFNSLWMHGLLPPHSS 85 
XP_016083226  25 MENLVLILSLFGTSFAIPVF-LQPG----GpPGMGSLSLETMRHLGN---LNLLPQFSRFGFGKQFNSLWMHGFLPPHSN 96 
XP_004009935  11 MKDVILILCLLKMSSAVPAFpQQPG----I-PGMASLSLETMRQLGSlqgLNLLSQYSRFGFGKSFNSLWMNGLLPPHSS 85 
XP_008265993  11 MKDLILLLCLLETSFAVPAFpQQPG----T-PGMASLSLETMRQLGSlqgLNALSQYSKYGFGKSLNSLWLQGLLPPPSS 85 
XP_005333329  11 MKDLILILCLLEMSFAVPMFpQQPGapgmA-PGMASLSLETMRQLGSlqgLNALSQFSRFGFGKSLNSLWLHGLLPPHSS 89 
Q62840        11 MKGLLLFLSLVKMSLAVPAFpQQPGaqgmApPGMASLSLETMRQLGSlqgLNALSQYSRLGFGKALNSLWLHGLLPPHNS 90  Norway rat
Q811C6        11 MKDLMLFLSLLKISFAVPAFpQQPGapnmApPGMASLSLETMRQLGSlqgLNALSQYSRFGFGKSLNSLWLQGLLPPPSS 90  domestic guinea...
XP_001489030  11 MKDLVLILCLLEMGSAVPAFpRQPG----I-PGMASLSLETMRQLGSlqgLNMLSQYSRFGYGKSFNSLWMNGLLPPPSS 85  horse
XP_012667598   8 MKGLLLTLWFLHVSAAVPVFpQQSG----V-PGMASLSLETMRQLGSlqgLNTLSQYSRFGFGKSFNSLWLQGLLPPQPS 82  small-eared galago
XP_018880683  86 LPWMRPREHETQQYEYSLPVHPPPLPSQPSLKPQQPGLKPFLQSAAATT-NQATALKEALQPPIHLGQLPLQEGELPLVQ 164
XP_016083226  97 YPWLSPRDQETQQYEYALPVHPPPRPSQRTLQPQQPKQNAFLPPTVAPSaQGPPAQNGDPQPPILHLQPPLQQEEKPSVQ 176
XP_004009935  86 LPWMRPREHETQQYEYSLPVHPPPLPSQPSLQPQQPGQKPFLQPTVVTS-MQNAVQKGVPQPPIYQGHPPLQQAEGPMVE 164
XP_008265993  86 FPWMRPREHETQQYEYSLPVHPPPLPSQPSLQPQQPGLKPFLQPTAAPA-IQGTAQKGGPQLRIHPAQLPLKDGEMPEIQ 164
XP_005333329  90 LPWLRPTEHETQQYEYSLPVHPPPLPSQPSLQPQQSGLKPFLQPTAATA-IQATAQKGGPQPPMHPRQLPLQDGEPPATE 168
Q62840        91 FPWIGPREHETQQYEYSLPVHPPPLPSQPSLQPHQPGLKPFLQPTAATG-VQVTPQKPGPHPPMHPGQLPLQEGELIAPD 169 Norway rat
Q811C6        91 FPWLRPREHETQQYEYSVPVHPPPLPSQPSQQPPQPGMKHFQQPTATPA-IQDTPQKAGPQPPMHPRQLPLKDAELPEAH 169 domestic guinea...
XP_001489030  86 FPWMRPREHETQQYEYSLPVHPPPLPSQPSLQPQQPGQKAFLQPTIVTSgIQDTIQKGGHQPPVYQRQPPLQQSEGPMVQ 165 horse
XP_012667598  83 LPWMRPREHETQQYEYSLPVHPPPLPSQPALQPQQAGLKPFLQPTAATA-VQGTAQKGRPQPPVHLGQLPLQEGELPAVQ 161 small-eared galago
XP_018880683 165 Q-QVAPSDKPPKPELPGVDFADPQGPslpgmdfpdpqgpslpgldfahpqgsTIFQIA-RLISHGPMPQNKQSPLYPGML 242
XP_016083226 177 E-QVAPPKRPPKPELPALDFTVQLRQ--------------------------SIFPIAqKLISQGPRQKAEQSPLYPELV 229
XP_004009935 165 Q-QVAPSEKPPTTELPGMDFADLQDP--------------------------PMFPIA-HLISRGPMPQNKPSPLYPGIF 216
XP_008265993 165 E-QVAPTEKPPKPELPAMDFAGPQVP--------------------------TVFQIA-RLIPRGPLPQNRHAALYPGMF 216
XP_005333329 169 Q-QVAPTEKPPTSKLLVMDFAGPQVP--------------------------SLFHIA-RVISRGPLPQNKPSALYPGMF 220
Q62840       170 EpQVAPSENPPTPEVPIMDFADPQFP--------------------------TVFQIA-HSLSRGPMAHNKVPTFYPGMF 222 Norway rat
Q811C6       170 E-QVAPTEMPLNPELPVLDFADPQIP--------------------------SVFQIA-RFVSRVPVPQNKPAMLYPGMV 221 domestic guinea...
XP_001489030 166 Q-QVAPSDKPPKAELREMDfpgp--------------------------qdpQMFPIA-RLIARGPMPPNKQAPLYPGLF 217 horse
XP_012667598 162 E-QVAPEEKLPKPELPIMDFAGPQGPs--------------------------IFQIA-RLIARGPMPQNKQSPLYPGMF 213 small-eared galago
XP_018880683 243 YVPFGANQLNAP-ARLGIMSSEEVAGGREDPMAYGAMFPGFGGMRPGFEGMPHNPAMGGDFTLEFDSPVAATKGPENEeG 321
XP_016083226 230 YVPFGANQQNAApARLGKVSSEEMPGGGGEPLAYGSIFPGFGSMRPGFGAMQINPALGKDFTLEDDSPTVAGKPPGQG-G 308
XP_004009935 217 YVTYGANQLNAP-ARLGIMSSEEMGGGRGGPVAYGAIFPGFGGMRPSLGGMPQNPDMAGDFTLEFDSPVAATKGPEKGeG 295
XP_008265993 217 YMSYGGNQLNAP-ARLGILSSEEMPGERGGPMAYGAMFPRFGGIRHSLGGMPHNPAMGGDFTLEFDSPVAATKGPEKGeG 295
XP_005333329 221 YTSYGANQLNAP-TRLGMMSSEEVDGGRGGPMGYGAMFPGFGGLRHSLRRMSPNPAMGGDFTLEFDSP-AGTKGPEKGeG 298
Q62840       223 YMSYGANQLNAP-ARIGFMSSEEMPGERGSPMAYGTLFPGYGGFRQTLRGLNQNSPKGGDFTVEVDSPVSVTKGPEKGeG 301 Norway rat
Q811C6       222 YMSYGTNQLSAPaARLGFMSSEEMPGGRVAPVTYGGLLPGLTGVRHTIRRVPQDPTMAGDFTLEFDTP-AATKGPEKGeG 300 domestic guinea...
XP_001489030 218 YLTYGANQLNTP-GRLGIMSSEEMAGGRGGPMAYGAMFPGFGGMRSSLRGMPPNPAMGGDFTLEFDSPVAATKGPEKGeG 296 horse
XP_012667598 214 YVSYGANQLNAP-GRLGIMSSEEMAGGRGGPMGYEAVFPGFGGLRPSLGGLPHNPAMGGDFTLEFDSPLAATKGPEKGeG 292 small-eared galago
XP_018880683 322 GAQGSPMPEANPDNPENPAFLTELEPAPHAG-LLALPKDDIPGLPRSPSGKMKGLP-SVTPAAADPLMTPELADVYRTYD 399
XP_016083226 309 EVLGSPRDGAIPAGHPNPGLLPERISRLRSGaALTFPSDFIPHRGQGPAGQSKLPP-GVTPPPADPLMTPGPSDPLEFFE 387
XP_004009935 296 GAQDSPVPEAHLADPESPALLSELAPGALGG-LLANPEGNIPNLARGPAGRSRGFLrGVTPAAADPLMTPGLAEVYETYG 374
XP_008265993 296 AAEDAPMPEANPSNPENPALLQEVAHGAHAG-LLAFPKDNIPGMARGPAGKKMGVP-RVTPSDADPLATPELAEVYDIYG 373
XP_005333329 299 EAQASPMQEANPANPKNPALLSQIAPGAHAG-LLAFPNDNIPNLARGPARQKKGPL-GVTPSAADPLMTPELAEVYETYG 376
Q62840       302 -PEGSPLQEASPDKGENPALLSQMAPGAHAG-LLAFPNDHIPNMARGPAGQR--LL-GVTPAAADPLITPELAEVYETYG 376 Norway rat
Q811C6       301 GAQGSPLHETKGEDPENAALLSQIAPGAHTG-LFGFPNDNVPSMARGPSGHRNRPL-EVTPVTADPLITPELAEIYETYG 378 domestic guinea...
XP_001489030 297 GPQGSPAKEADEANPENQALLSEIASGPLGG-LLALPKGSVPNLARGPAGQSRGPP-RVTPAAADPLMTPGLAEAYETYG 374 horse
XP_012667598 293 GAPDTPGPEASPAHPEQPALPPELAPGAHPG-LLAFPDDEDPSLARGPAGQRLGPP-GVTPAAADPLMTPELADIYGTYA 370 small-eared galago
XP_018880683 400 ADMTTSVDFQEEATMDTTMAPNSLQT-SMPGNKAQEPEMMHDAWHFQEP 447
XP_016083226 388 GDGTTPLGLQREALLDTTMTPDTQST-YMPGNEAQQMQVTQDQWQFQEP 435
XP_004009935 375 ADETTTLGLQEETTMDSTATPDTQHP-LMPRNKAQQPQIKHDAWHFQEP 422
XP_008265993 374 PDVTTPLGTQEETTTDTTMTPDTQET-SIPGNKDQHSQMMHNAWRFQEP 421
XP_005333329 377 DDVTTPLD-TGEATMDTTMTPDTQQT-SMPGNKVHQPQMVHDAWRFHEP 423
Q62840       377 ADVTTPLG-DGEATMDITMSPDTQQP-PMPGNKVHQPQ-VHNAWRFQEP 422 Norway rat
Q811C6       379 GDVTTPLG---EATMETTMTPDTPQT-PMPGNKVRQPQMVHEPWHFQEP 423 domestic guinea pig
XP_001489030 375 ADVTTPLDFEEETTTDTTVTPESPQT-SMPGNEAEQPQMVHDAWRFQEP 422 horse
XP_012667598 371 ADVTTPL----EATTDTTGAPDLLETsSAPGNRAQQAQAAREVWRYQEP 415 small-eared galago
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