Conserved Protein Domain Family
GLYCAM-1
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pfam05242: GLYCAM-1 
Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1)
This family consists of the lactophorin precursors proteose peptone component 3 (PP3) and glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1). GlyCAM-1 functions as a ligand for L-selectin, a saccharide-binding protein on the surface of circulating leukocytes, and mediates the trafficking of blood-born lymphocytes into secondary lymph nodes. In this context, sulphatation of the carbohydrates of GlyCAM-1 has been shown to be a critical structural requirement to be recognized by L-selectin. GlyCAM-1 is also expressed in pregnant and lactating mammary glands of mouse and in an unknown site in the lung, in the bovine uterus and rat cochlea.
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Statistics
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PSSM-Id: 368355
Aligned: 3 rows
Threshold Bit Score: 138.297
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002923492  20 LGESEEETHWETQPIDA--PAQLI----PEKDHVSIENSSEETPISTDELRFEEeDVISSIRKLKNQRlqqlqpipQEAS 93 
Q02596        20 LPGSKDELQMKTQPTDAipAAQSTptsyTSEESTSSKDLSKEPSIFREELISKD-NVVIESTKPENQE--------AQDG 90  house mouse
XP_004006317  20 LNEPEDETHLEAQPTDA--SAQFI----ISNLQISTEDLSKEPSISREDLISKEpNVIRSPRQPQNQNpklplsifKEKH 93 

XP_002923492  94 FRNAAPRSEETTELTPEltpwAATTPEGKLAKLGHEIGKNLDRTMKETMNYLKSLLPHAYEVTRP 158
Q02596        91 LRSGSSQLEETTRPTTS----AATTSEENLTKSSQTVEEELGKIIEGFVTGAEDIISGASRITKS 151 house mouse
XP_004006317  94 LRNASLGSEETTEHAPS----DASTTEGKLMELGHKIMKNLENTVKEIIKYLKSLFPPASEVVKP 154
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