1HXM


Conserved Protein Domain Family
IgC1_TCR_gamma
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cd07697: IgC1_TCR_gamma 
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T cell receptor (TCR) gamma chain constant immunoglobulin domain; member of the C1-set of Ig superfamily (IgSF) domains
The members here are composed of the immunoglobulin (Ig) constant (C) domain of the gamma chain of gamma-delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha-beta TCRs, but a small subset contain gamma-delta TCRs. Alpha-beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma-delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing and MHC independently of the bound peptide. Gamma-delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds.
Links
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Statistics
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PSSM-Id: 409494
Aligned: 4 rows
Threshold Bit Score: 152.414
Created: 17-Oct-2008
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1HXM; human gamma/delta T-cell receptor gamma chain IgC domain forms a heterodimer interface with the delta chain IgC domain, defined using 4.0 A contacts.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ### # ##  #    # # # #                      # #  #         # # #           
1HXM_B    131 SPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDVIKIHWEEKKSNTILGSQEGNTMKTn---dTYMKFSWLTVPEKSLDKE 207 human
AAM21533   94 NPKATILSTSKKVIEKQGQGIYLCLLENFFPDAIQVVWRKGNKDIPSEQGEIKSEKDkdnndVYSTTSWISVTKDDLGNK 173 African clawed frog
AAO75101  150 SPKPTIFLPSIAETNLHKAGTYLCLLENFFPDVIKIHWQEKKSNTILGSQEGNTVKTn---dTYMKFSWLTVPEKSLDKE 226 Macaca mulatta
AAY82093  143 APEPIKFFPSSLEQEKQNTESYICLFKDFYPDVIRMHWKEEGSDKILESQQSDPFRVk---dKYWQMSWLTVKKSSPGKI 219 platypus

Feature 1                                 #  
1HXM_B    208 HRCIVRHEnnkn----------gvdQEIIFP 228 human
AAM21533  174 FTCHYKHEgiskqenwdevsvvgskSSIVVP 204 African clawed frog
AAO75101  227 HRCIVRHEnnkn----------gvdQEIIFP 247 Macaca mulatta
AAY82093  220 YRLIYKHEktgr----------vekEELFPA 240 platypus

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