Conserved Protein Domain Family
OAF
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pfam14941: OAF 
Transcriptional regulator, Out at first
This family of proteins is found in eukaryotes. Proteins in this family are typically between 198 and 332 amino acids in length. The domains in this family vary in length from 239 to 242 amino acids. The gene, OAF (out at first), which encodes this protein, has a promoter which may help mediate regulation of neighbouring genes. An alternative name for this protein is HCV NS5A-transactivated protein 13 target protein 2, which stands for Hepatitis C virus nonstructural 5A-transactivated protein 13 target protein 2. NS5A inhibits double-stranded-RNA-activated protein kinase (PKR) activity, which is thought to allow Hepatitis C Virus replication to continue in the presence of an alpha interferon (IFN)induced antiviral response.
Links
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Statistics
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PSSM-Id: 464389
Aligned: 15 rows
Threshold Bit Score: 375.523
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001603817  24 TNLLINVKNQGGDILQETITSNITEDVITLEFQRSDGTLVTQLVDFKNEVQVIKALVLGEEERGQNQFQIMCFVNHFYKM 103
XP_001947065  23 SCLVVNVKDQDGSVIKEIIYANITDDTITLELQLPDSTLITQHIDFTKEVQIVQVLLLGEEERGQKPYQILCFVNHVHAN 102
OWR49235      21 LQLLINVKNQGGDVMQENITANVSEDTVTLEFLRLDGIYVSQLVDFTNEVEAMKIVIPAEEELGQTGHQILCFLTHAAQA 100
XP_002021531  83 AQLLINVQNQGGEVIQESITSNIGEDLITLEFQKTDGTLITQVIDFRNEVQILKALVLGEEERGQSQYQVMCFATKFNKG 162
XP_001638157   9 SRLAVNVKTKAGDITKQVFESFPEKELVKISFRLNDGRYIDISLDFRKKIQVIKAIILGEMDKAENPYEAVCFAIKLTDG 88 
XP_005988160  30 SELKVRVRLADGRLTQESLEADSERDSISLEFKQGDGTLVTMIADFKQDVKIFRSLILGEMERGQSQYQALCFITKLQRN 109
XP_002693075  42 SELRVRVRLPDGQVTEESLQADSDADSISLELRKPDGTLISFTADFKKDVKIFRALILGELEKGQSQFQALCFVTRLHHN 121
Q71SY6        27 AELRVRVRLPGGQVTEESLQADSGSDCISLELRKADGALITLTADFRQEVKIFRALILGELERGQSQFQALCFVTRLHRN 106 chicken
CAF97497      30 SELRVRVRLSDGLVTEEVLEADSERDAISVEFKQGDGTLITYVADFKQDVKIFRALILGELERGQNQYQALCFVSRLNRN 109
ESO05785      19 SQLIINAKNKGGDVFKEFIEANTTYDTISLDFMTADGTLVTHFVDSKNELQIFKLSLLPEDDLFQTGVINFCFVTRITKN 98 

XP_001603817 104 DFISSDAMSKLRQKNPGTIRTAEEDKGHANYTMDLFLDVSQSSVVSKHISDICSEAADSTFTRYEDIKHWAQR--PGSSE 181
XP_001947065 103 EFISPDAMSKLRQKNPGTIRVAEENKGVFNITIDMKIKSKDSNYISQHVGSLCSEAQDTTFTSKVDIDKWATV--PGMYL 180
OWR49235     101 DFIAPDAMAKLRQKNPGTVRVAEEDKGWRQTTTTAWAGCA-TRLLSPAAARHCSAARDRVYLRTADLTRWGPR--PGLEQ 177
XP_002021531 163 DFISSAAMAKLRQKNPHTIRTPEEDKGRETYTMSSWVQLNRSLPITRHLQTICAEAMDATYVRDVDLKSWAEL--PGSSI 240
XP_001638157  89 EYVTPDAMSKLRQKNPDTIRSPEVDVGTEEIVLDQLVPVTNAGVLTDQVYSMCEEV-GFVFTKQEDIKNLISD--NYTTI 165
XP_005988160 110 EIIPSESMAKLRQKNPKAIRTAEEQRGAEQLTMDVAVNFSKAVQLSAHIHNVCTEAKEAIYTREADVKYWLERgvDGSMF 189
XP_002693075 122 EIIPSEAMAKLRQKNPRAVRQAEEVRGPEQMHMDIAVNFSQGALLSPHLRNVCAEAVDAIYTRQEDVRFWLEQgvDGSVF 201
Q71SY6       107 EIIPSESMAKLRQKNPRTVRQAEEVRGLEHLSMDVAVNFSKGAQLSSHIHNVCAEAKEAIYTREEDVKFWLEKgmDGSMF 186 chicken
CAF97497     110 EIIPSESMARLRQKNPQAIRLAEERKGLEQLTMSVAVNLSRAWQLSSHIHNMCSEAREAIYTREADVKHWLDKgvDGSIF 189
ESO05785      99 EFISSDAMSKLRQKNPSAMRHPEEQLPTSIYTMDVMLNARASHLLSPHINSLCKTAKYSTFAEQADIKLLAQI--MNKNY 176

XP_001603817 182 AALLLAVHNFTLataiqasvnakpSVISKCADTSNLWAPCTCSLELCIGWYPCGLKFCK---TKGDGk-------kVAST 251
XP_001947065 181 GNLLQAVEYINYks--------pnSNLKLCRDTGKVWSHCLCTMKVTIPWYPCALKFCKdhiGKKST---------AVDS 243
OWR49235     178 SSYSSEVTPFPShvlmsd-tadgkPAVGVCVAETDAGKECICHLEVCVNWYPCGLKYCK---GKPQG----------GLS 243
XP_002021531 241 SSLEAATEKFPD------------TLSTRCNEVSSLWAPCLCTLETCIGWYPCGLKYCK---GKGAGadssgaqqqQQTN 305
XP_001638157 166 PLFMSSVQNLSSn----------mISRKRCHDTKESKVPCICRLQVCISWYPCDLKYCQ---GQDSDg--------KPTE 224
XP_005988160 190 EILPR-SSDIP--------------ELQRCRMSFDRWKPCVCRYALTIEWYPCLLKYCK---SKDGTg--------KVSS 243
XP_002693075 202 EALPK-ASEQV--------------LLPRCGHVGDRGKPCICRYGLSLAWYPCMLKYCH---GRD-----------RPAP 252
Q71SY6       187 EVLPQ-TSDLP--------------DLQRCKLCTDRWKPCICSYSLSIEWYPCMLKYCK---SRDAAg--------KVSS 240 chicken
CAF97497     190 EMLPQ-TAEAT--------------GFQACHSTKDMWQPCLCTYSLRLEWYPCLLKYCR---SRDGTg--------KSSS 243
ESO05785     177 SLLEESMKKLPDi----------nGNHSACSHTSTETSPCICHLTVCVEWYPCGLKYCR---GRDSQs--------RVLN 235

XP_001603817 252 YRCGIKTCKKCFIFSYYSKMKQNCLWDE 279
XP_001947065 244 YRCGIQTCGKIMNFMYIVKHKQHCLTIE 271
OWR49235     244 YRCGIKTCHRCYRYQYYVHRRDSCLSYL 271
XP_002021531 306 YRCGIKTCRKCTQFTYYVRQKQQCLWDE 333
XP_001638157 225 YRCGIKTCGKCHDLDYLATEKRHCFWDD 252
XP_005988160 244 YKCGIRSCQKGYQFHYYVPQKQLCLWDE 271
XP_002693075 253 YKCGIRSCQKNYSFDFYVPQKQLCLWDE 280
Q71SY6       241 YKCGIRSCQKGYTFDYYVPQKQLCLWDE 268 chicken
CAF97497     244 YKCGIKSCSKGYHFTFYVPQKQLCLWDE 271
ESO05785     236 YRCGIKTCKKCSVFKHYVSSFLMCTWDE 263
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