Conserved Protein Domain Family
SPICE

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pfam15678: SPICE 
Centriole duplication and mitotic chromosome congression
SPICE is a family of proteins found in chordates. It localizes to spindle microtubules in mitosis and to centrioles throughout the cell cycle. Deletion of SPICE compromises the architecture of spindles, the integrity of the spindle pole and the process of aligning chromosomes on the spindle (chromosome congression).
Statistics
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PSSM-Id: 464796
Aligned: 17 rows
Threshold Bit Score: 208.144
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5RKG1        35 VNDLTVHRATPEDLVRRHEMHKSKNRALVHWELQEKALKRKW-------KKQKPETSS-IEKRKLSIMKEILSDQYQTQ- 105  Norway rat
XP_001748050  18 VHDLSEHKLSSAALRRRKEAHASRHANQAKQLLQA---QRRR-------NLAQPQTPPqPHTPTTGVFRLLKAFRMHGAr 87  
XP_002606849  36 TSDLSVHKATDEEIKHRHEVHQSKNLDVIRLENQKMMIQKDScfnyiciARARPKTPStVEKRKAALLREVLYDHSQ--- 112 
EDO48168      47 VNDLNVYKASEDEVRQRHEAHKSKNYGLPRKQATNKE------------NSPGYITTPnSAQRKQAILQEILYGRDQFQ- 113 
2_pfamImport   1 VNDLSVHKASPAELIHRHEIHKSHNRAAAQWELREKDLQRRL-------R--RAGSPApLDDASLSIIREVFSDQLLLQ- 70  
XP_011487240  35 VHDLSVHKPTPAELTHRHEIHKSRNKAVAQWELKEKALKRCA-------R--QAGSPApLDPASLSIIREVFSDQLLLQ- 104 
XP_023181771  35 VNDLSVHKLSPAELCHRHEIHKSHNKAAAHWELREKALKRRL-------R--HAGSSPgLDHTSLTIIRDVFSEQPLLH- 104 
XP_008118673  35 IHDLSVLRATPEDIAIRHEMHKSKNRALAHLELQEKSLENTR-------NKLRPRAPQsVEKKKLDLMRAIISDQYQLH- 106 
3_pfamImport   1 VHDLTVHRATPEDILRRHEIHKSKNKALAHLELQEKTLRRKW-------KKQKQLAPDsLEKRKLALMHEILSDQYDLQ- 72  
XP_014346282   1 -------------------MHKSKNRSLAQWELRERALRKKL-------RKQGQGSPDiLEKRKLAIMREVLFDQYQMQ- 53   coelacanth
Q5RKG1       106 DVLEKSDHLLTAAKG-----LF-----------------VDVPRKRTGFPNVTMAPG----------------------- 140  Norway rat
XP_001748050  88 GVLTHIPSLLSSPRDacdrcLFpraalprrrfvlppnhaGQAPLRRTLRPGLEAFEDddndvhghddddddldygaedny 167 
XP_002606849 113 DVLSKSDRVMAVVRD-----LF-----------------GDDPKRYTGFPNVTKAPDn---------------------- 148 
EDO48168     114 DVLAESDRTMSVVKD-----LF-----------------GDDPKKYMGFPNITVPPQvls-------------------- 151 
2_pfamImport  71 DVLARSDRAMAVVKD-----LF-----------------GDAPRRQTGHPSVTMAPNcd--------------------- 107 
XP_011487240 105 DVLARSDRAMAVVKD-----LF-----------------GDAPQRQIGHPSVTMAPNcd--------------------- 141 
XP_023181771 105 DALAQSDRALAVVKD-----LF-----------------GDAPRRQTGHPSVTVAPNcd--------------------- 141 
XP_008118673 107 DVLEGSDQAMAVVKD-----LF-----------------GDAPHWHLGFPNVTVAPDhd--------------------- 143 
3_pfamImport  73 DVLKRSDQVMAVVKD-----MF-----------------GKAPHTRTGFPNVTMAPNcd--------------------- 109 
XP_014346282  54 DVLERSDRAMAVVKD-----LF-----------------GDAPHRHAGFPNVTMAPDse--------------------- 90   coelacanth
Q5RKG1       141 ---------------SSRSPAGINQDPGTQ-SILNESIIEPQ--ALNEvdd-ggAESTAHSQSEDS--ESELPNSL--SP 197  Norway rat
XP_001748050 168 vytadllqsphnrrpRGGQPVLAARAYRTVvPGTANSSFEEThaAHNDtaaqrqYGYHAPGGASASpsERAVDWEHyaQV 247 
XP_002606849 149 --------------pSGRGPVIEPPEQPTQlSMLSQSIMDQS--ALNEvd----------aeREQGeaGEEQTLSQ--QF 200 
EDO48168     152 ------------entERNGPIAEVPEAQTQlTQLSESVMQTA--ALNEis----edEGNSSGTEPSpqSNQNQAAQrmTF 213 
2_pfamImport 108 -------------sdSGL-PVLQRPDPPTQlSLLSQSLMDPQ--ALNEle----------asEEDY---SDEDPGP--TG 156 
XP_011487240 142 -------------sdTEL-PVLERPDPPTHlSFLSQSMMDQE--ALNDle----------vsKENR-------RVE--NT 186 
XP_023181771 142 -------------sdSEL-PVLQRPDPPTQlSLLSQSIMDQE--ALNEve----------vsREDV---RDEDLSS--SS 190 
XP_008118673 144 -------------veSSEDLIVQKCDLPTQlSILSESVMDPQ--ALNEke---eCSFVCNTNSEGG---------VylNT 196 
3_pfamImport 110 -------------leSSQGPIVQKWESPTQlSILSESVMDSQ--ALNEge---eEEALSICQSENG--QHE---SL--NF 164 
XP_014346282  91 -------------mdTSVGPIAQKRDSLTQlSILSESVMDSQ--ALNEd-----VENSQSECSEDG--EEEVDASM--NF 146  coelacanth
Q5RKG1       198 HSNRNTERFLHQLKEENSElinq-lwtdIQQKIAAQS--QRTPPGSPSSEL-S--------------AEDQ--------- 250  Norway rat
XP_001748050 248 VSDARERR-----AEQESQllsslervqAWAEKSADQiqEPNSPSRLTSATlQ---------------QQQae------- 300 
XP_002606849 201 ESRLDLQRFRRFLEQERQQds------tLRQQDSTLRqqDSTLSTIPGEQQ----------------GQQGaatstmlqa 258 
EDO48168     214 QPRLDLQKFKEFVSQEQND-----------------SgqPSYEVKNPISASrSqgiprgkvlqpavqAEDHss------- 269 
2_pfamImport 157 RSDYDVIRRNNVQKMKAQSrgrl-vqrqK---VNSKQagRDNDPVTPCTSGrA--------------SAQ---------- 208 
XP_011487240 187 SSDSHVIHRVTGRKSKSQSgsgv-lrqqKMHHSNFHHadSDDGPVTPCASRkP--------------PNQN--------- 242 
XP_023181771 191 GSRF--IRRTNIRKTKTQTrat---qkqKGHRLRSHAgdKENIPVTPIRSGrA--------------PDP---------- 241 
XP_008118673 197 RSNIDTKRVLNLLKEDNSvanc--qpeaSKQHISTVSteEVDILLTPAASF-Q--------------SLEH--------- 250 
3_pfamImport 165 KSSINCDRLLRILREENSSanse-lwaeRDLRKTTVSq-E--IPLTPTIAS-S--------------SLEHsv------- 218 
XP_014346282 147 KSSVDMNRFRCLLNEKDNS---------FSQSRTKPPplAGNLPKTPKTPVrP--------------STAEp-------- 195  coelacanth
Q5RKG1       251 -K-GALNATDAVKRIQAGLQPEESAEp------VDSSY-VGQVL--NTRKPKPLLSKVKRKQDMRALSKQKKNMLSSSTT 319  Norway rat
XP_001748050 301 lA-AQTQAQDAAKALVAQLVSER----------------VDQL---ETRLRQALQPGTESPRSTQAPASDPLGATT---- 356 
XP_002606849 259 gTsHQVESSNPVRTVNMSQVQPTAVNtqtpvrdVDSTSlTNQAIndTAKVTRTRSRAGAADHT----------------- 321 
EDO48168     270 fL-SGTSGNTILAGAPNFMFPAQQSS-------GEPTAiAE--IpgSERLEQAGEVKARVKSNEKAPKLKATVKPAQGPK 339 
2_pfamImport 209 ---AALNATMAVQRLRSRRSQSEEGM-------EEPEVlVSQVLnpDVPLNQS-GRISSRTSRGRNGVSQRSALDGSSVA 277 
XP_011487240 243 ----ALNATVAVQRVRSKHFEEN--E-------EETSSqVSQVLnpEPLLCRS-GRSGSCTRKVRKCVSHGSELDGSTAA 308 
XP_023181771 242 ---TALNATAAVKRFLTKQRPSDQNE-------EEASVlVSQVLnpELPSRQS-GRIRKHTEKTRKGVCRALELDGSSVA 310 
XP_008118673 251 ---TALNATHVVKKVHSRFQNEEQt--------ADTPCtIQQVLnaKVKKQKHTSTKVKKKQTAQTPTGQTRINLNATSA 319 
3_pfamImport 219 fK-SALNASSVVKRIHSRHQNQDEEEt------VDSAYtVRQVLnpNSRKEKQISAKRKYNSNCHPCSSEKPNTVNDKTC 291 
XP_014346282 196 --sSALNATTVVRRVKSRLGMGDGASaalnglsPENTLvVGQVLnpGPGKKKRTAAKGKKSRRADAPSAKERECYQPSSS 273  coelacanth
Q5RKG1       320 SA-DLASSNNSSLDVLKHMIHEVEHEMEEYERWT-GREVKGLQ--GGQGLTG-FTLSLVSSLCRLV---RYLKESETQLR 391  Norway rat
XP_001748050 357 ---TLAAGTGPSNGTPSHNRTDV----------------------PGTQLHG-PMLAILEFMDRLVdgtAQLSTTQAQLG 410 
XP_002606849 322 ---DLSSLSLTKLDELKQVMDNLEAEIADYEHQAgMPTPPPPQqhKSPTLRG-YTTSLLEAITRLT---RHIKESESQLR 394 
EDO48168     340 GL--------RCLDDLKKMVENLEDEIAEYEMET-GRESSGKTn-QTNSFSG-YTSALVIAVTKLM---RYLKESEIQRR 405 
2_pfamImport 278 SL----SGDQSSLGLLQTMLGQVEADLDTLIPATePASAQSQKtdKAQGLTG-FSVALVSTLGRLV---HLLKQREEKAQ 349 
XP_011487240 309 SL----SGEQSGLGLLQAMLGQVEADLDAFCPQM-ASAQSLKQh-KTQSLTG-FSVALVSTLGRLV---HLLRQAGEDTQ 378 
XP_023181771 311 SL----SGDQSSLGLLQDMLGQVKADLDTMSSDIaPEPTGSPEpyERQGLTG-FSVSLVSTIGRLV---QLIRKREAEAQ 382 
XP_008118673 320 SV----NGQNSSLEYLNQMLHDLEHDIEEYERWM-GHEVQYVH--SREGVSG-FTHSLVHALNRML---HCLKQTETKVR 388 
3_pfamImport 292 CLiYSQKNNKNYEENLESK-KSLKEEDSEYERIT-RKDIFGLQreRSQGWSSyFVLSLVSEKPLLF---QPVKVSEMQLH 366 
XP_014346282 274 TF-NLSNGNQSSLEVLHHMIGEVEQEMEEFERQT-GRMVKDQRsqTGQGLTG-FTASLLGTLSRLV---RYLKETEVGVR 347  coelacanth
Q5RKG1       392 KEVETRQQLEQMLGDHRELIDA---LTAEILLLREENGAVQARLQQ 434  Norway rat
XP_001748050 411 AQQERTAERLNSLEHAQQATDArleQQHEVLTTLEASLRAHGDARE 456 
XP_002606849 395 SEATLRHHLMEEIAEQRALVDV---LTADIINTQEQYTVLRGEFDQ 437 
EDO48168     406 AEAVIRDQILQGFAEQRTLIDA---LTNDIVQTQEQNMILQEEMHV 448 
2_pfamImport 350 EEARERRILEEVSREQRGLIDA---LTAETMALREEAAALQSGLQQ 392 
XP_011487240 379 KETEGRRRLEGELKEQRGLIDA---LTAETMALREEAAAVQadlqr 421 
XP_023181771 383 EEAEERRRLQEDLKEQRGLMDA---LTAETMTLREEGAAMQAGLlq 425 
XP_008118673 389 QEIINRQQLERELSEHRVLIDA---LTAEILLMREENFAMQSTFQr 431 
3_pfamImport 367 EKEMMRQHHEEMLNEHRELIDA---LTAEILLVREENIAIQKKLQQ 409 
XP_014346282 348 WGQRETERLREQSREQRQLIDA---LTAEMLSIREELTVAQTRLQQ 390  coelacanth
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