Conserved Protein Domain Family
CCDC154

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pfam15450: CCDC154 
Coiled-coil domain-containing protein 154
CCDC154 is an osteopetrosis-related protein that suppresses cell proliferation by inducing G2/M arrest.
Statistics
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PSSM-Id: 464723
Aligned: 8 rows
Threshold Bit Score: 750.896
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_023353576  39 GSSKFTIEQDSPKRWKQLEQWVADLQAEVVCLRGQKERSDQAVLSLLRELLQIRARIQVQDSELELIRDEV-KQLTRIPE 117
XP_013970187   7 HLPPPCPERDSPGHWRQLEQWVADLQAEVASLRGHKDRCERAMLSLLREMLQLRACGQLQDAELKRLQQDV-RQAVQAPD 85 
Q6RUT8        48 ASGSLVPEQDTSKLWKQLEQWVAELQAEVVRLRGHKERCEHATLGLLRELLQVRARVQMQASELRQLRQVV-QQAAWSPE 126 house mouse
XP_023416447  65 VSSSPPPEQDISKH---LNECVAKLQAEVVSLRGHKVHCEQASLSLQRELLQVHGHMQQQSSELQQLWQEI-KRVAHVPE 140 domestic guinea...
XP_024841058  56 QSEASDLEQGTLKRWKQLEQWVADLQAEVASLRGHRARCEHATLSLLRELLQVRACLQLQDTQLKRLQLET-RRVAPAPE 134 cattle
XP_023620241  84 ASTTSVPEQDTPKRWKQLEQWVADLQAEVVSLRGHKDYCERATLSLLQELRQVQASVQLQDSELKKLKQEL-QQAAWVPE 162 little brown bat
XP_012661141  82 VSTTSVPEQDTAKRWDQLEQWVASLQAEMARLQGHEERCEHTMLSLLRELVRLRAHVQLQGSELTQLQREVqQQAARTPE 161 small-eared galago
XP_013219456  84 ASNACVPEPSTSKRWEKLEQWVGDLQAEVACLRGHKERCEHATLSLLRELLQMRAHMQLQASELRQLRQEM-QQVAQAPE 162 thirteen-lined ...
XP_023353576 118 KEACEPSSATG--RSHMELMEKRLVEVREALTQVRRKQALQETEKKNFETELTLRLDKLNGDLKEEAEGRETACSTLLQN 195
XP_013970187  86 KEVLECPGAQN--QNHMQTLDKRLVEVREALTQIRRKQVLQDSERKDAEQEASLRWAELAGKLEQEEQLREAACSALQKS 163
Q6RUT8       127 KEELELSGPQS--QNQMQTLDKRLVEVREALTHIRRKQALQDSERKHSEQEINLRLTNLTGMLSQEEQGREAACSALQKN 204 house mouse
XP_023416447 141 KEVQVFSGAQN--QNQIQILDKRLVEVRESLTQIRRRQALQDAERKGSGQEANLRLTKLSGWLRQEEQAREAAYSSLQKS 218 domestic guinea...
XP_024841058 135 KEAVQLPGPQQ--QNQMQALDKRLVEVREALTQIRRKQALQDSERKGAEQEASLRLSELTGKLKQEEQDREMACGALQKS 212 cattle
XP_023620241 163 KEALEFPSPQN--QNKMQALDKRLVEVREALTQIRKQQALQDSERKGTKQEANLRLTKLARKLEQEEQNREVACSALQRS 240 little brown bat
XP_012661141 162 KEAPEFLGPQNqnQNQMQALDQRLVEVREALAQIRRKQTLQDSERKGAEQEAALRLATLTDLVKQEEQGREAACSTLQKS 241 small-eared galago
XP_013219456 163 KEALEFPGPQN--QNQMQALDKRLVEVREALSQVRRRQALQDVQRKGAQQEANLRLTKLTGLLKQEEQGREAACSALHKS 240 thirteen-lined ...
XP_023353576 196 QEESACRTSRDIAGIQAQALQLGEEMSLKFLKREAKLCGHLQKNFMAIEKKMKVSENTRLKSEKNLWEELEVKWQKIQVL 275
XP_013970187 164 QDEASRRVDREVARMQAQVTKLGEEMSLRFLKREAKLCSFLQKSFLALEKRMKASESTRLKAESSLRGELDSRCQRLQDL 243
Q6RUT8       205 QEDTSQKVDLGLAKMQAQMTKLNEEMSLRFLKREAKLCSFLQKSFLALEQRMKSSESTRQIAESSLREELESRWQKLHEL 284 house mouse
XP_023416447 219 QEDTSQKVDHEVAKMQAQLTKLGEEMSLRFLKREAKLCSFLQKSFLALEQRMKALEGTRLETERSLREELEGHWQKLQEL 298 domestic guinea...
XP_024841058 213 QEEAGQKVDHEVTRMQAQMTKLGEEMSLRFLKREARLCGFLQKSFLALEKRMKASESARLRAESALREELEGRWRQLQEL 292 cattle
XP_023620241 241 QEEASQKVDQEVARLQAQVTKLGEEMSLRFLKREAKLCGFLQKSFLALEKRMKTSESTRLKVESSLREELESRWRNLQEL 320 little brown bat
XP_012661141 242 QEDASQKLGHEVARMQAQVTKLSEEMSLRFLKREAKLCSFLQKSFLALEKRMKAAESSRLRLECRLREELEGHWEALQEL 321 small-eared galago
XP_013219456 241 QEDASQRVDHEVAKMQAQVTKLGEEVSLRFLKREAKLCSFLQKSFLALEQRMKASESTRLQAEGSLREELEGRWQRLQEL 320 thirteen-lined ...
XP_023353576 276 NEDHFRSLKHQQE-QEESRLLDQCRALDNAVIQLTEFVRENQTSLNRVLQAEQKNREAQEQYEKESVEKFTMKLQNDISA 354
XP_013970187 244 AEERAQALQGQQE-QEECRLLEQCRDLDQAVIQLTNFVHQNQVSLNRILLAKQEAWDSKGQAEESRAGELAAYVQESLAA 322
Q6RUT8       285 TEERLRALRAQRE-EEEGHLLEQCRGLDKAVVYLTKFVRQNQVSLNRVLMAEQKAREAKVSLEETQAGELASYVHENLEA 363 house mouse
XP_023416447 299 TEERVQALWGQHEqEEEGCLREQCRGLDAAVVRLTKFVRQNQMSLSHILLMEQKARVSKVGLEESQAEELASYMQENLEA 378 domestic guinea...
XP_024841058 293 DTERVRALQGQCQ-QEECHLLEQCRGLDKAVVQLTEFVQQNQVSLNRVLLAEQKAWDAKGQLEDSRAGELATYLQENLEA 371 cattle
XP_023620241 321 AEERLQALRGQCK-QEESYLLEQCRGLDRAVVQLTKFVRQNQVSLNRVLLAEQKAQDTKGHLEESQAGELAAYLQENMEA 399 little brown bat
XP_012661141 322 TEERLRSVCGQRq-QEQGHLLAQCRSLDAAVVQLTKFVRQNQASLKRILMTEQKARDAKGCLEESQAEELASQVQESLEA 400 small-eared galago
XP_013219456 321 TEERMQALGAQRq-EEEGHLLEQCRGLDAAVVQLTKFVRQNQVSVNRILLAEQKARDTKVCLEESQAGELASFVQENLEA 399 thirteen-lined ...
XP_023353576 355 VRESFDNAHREARSELEKIQEKSQVLEESIGRLVREVRDLSDHFVALSWKFDLQEQTLNLKMSE-------ARKECSEEE 427
XP_013970187 323 MQLAGELTQREAHGALQLLREKSQALEESLAELGKQVKDLSDHFVALSWRLDLQEQMLRLRLSE-------AKREWEGLE 395
Q6RUT8       364 VQMAGKLAQQETQDALELLQEKSQVLEGSVAGLDQQLKDLSDHCLALSWRLDLQEQTLGLKLSQ-------KQAAWEGME 436 house mouse
XP_023416447 379 VQLESKLAQKETQDAVELLQEKSQVLEKSVAKLAQQLKDLDDHCLALSWRLDLQEQTLGLRLSEt-----kTQ--WEGVE 451 domestic guinea...
XP_024841058 372 MQLAGELAQQETQGALELLREKSQALEVSVAELVRQVKDLSDHFLALSWRLDLQEQTLSMRLREtqsewevAE------- 444 cattle
XP_023620241 400 MQLASEQARQETQSTLELLQEKRQALEGSVAELVTQVGDLNDHFLALSWRLDLQEQTLTQKLCE-------AKSEREGAE 472 little brown bat
XP_012661141 401 AQLANDLAWQETHRQLAVLQEKSQGLEASVAQLAGQLKDLNDQFLTLSWRLDLQEQMLGLRLSE-------VRNEWEGAE 473 small-eared galago
XP_013219456 400 VQLAGELTRQEMQGALELLQEKSQVLEGSVAQLARQLKDLSDHCLAVSWRLDLQEQTLGLKLSE-------VKTEWEGVE 472 thirteen-lined ...
XP_023353576 428 KKALEKFIQWQNETIVHLKELQEKVESFLKQIGDVNDRCLLHRNDSDQKIITESRTRKHEMGIVRQELAVVLSALQLLKE 507
XP_013970187 396 QKSLEGLVQCRKEVEAHLREVWERVDSLPRQIEAVSDKCVLRKSDSDLRISAEGKAREFDFEAMRQELAAVLSSVQLLKE 475
Q6RUT8       437 RESLKDLVQWLKEVTAHLEEVQEKVNSLPQQIESISNKCVIHKSEVDVKISAEGKAREFEVETVRQELAALLMSVQLLKE 516 house mouse
XP_023416447 452 RKSLEDLAQRQKEVAAHLQEVQEKVDRLPQQIEGVSDKCILHKSDADLKILAEGKAREFEVKVMRQELATLLSSVQLLKE 531 domestic guinea...
XP_024841058 445 QRWREGLTRCREEAEAHLREVQERVDQLPQQIEAVTDKCVLHKSDSDCKISAEATARELAVEAVRQELAALLSSVQLLRE 524 cattle
XP_023620241 473 RRSMEGLAWCRKEAQAYLREVRETVDSLPRQIEAVSDRCVLHKSDSDLKISAEGKAREFEVEAMRQELAALLSSVQLLRE 552 little brown bat
XP_012661141 474 RRSVEDLARWQKEVAAHLRGMWEKVDSLPRQIESISDRCIFHKSDSDLKICAEGRARESEVGALRQELTALLSSVQLLRE 553 small-eared galago
XP_013219456 473 RKSLEDLARWQKTVSTHLREVQEKVDGLPRQIEGVSDKCIFHKSDTDLKISAEGRVREFEVGAMRQELATLLSSMQLLKE 552 thirteen-lined ...
XP_023353576 508 DNPNRKIAEIQGKLTTfqSQIMKMENNIQDNKTIQNLKFNTETKLRVEEIAHLRENV 564
XP_013970187 476 GNPGRKIAEIQGQLATfqNQIMKLETSIQDNRTIQNLKFNTETRLCMEEMASLRESV 532
Q6RUT8       517 ENPGRKIAEIQGQLATfqKQMIKLENSLQANKTIQNLKFNNETKLRTEEIATLRESM 573 house mouse
XP_023416447 532 DSPGRKIAEIQGKLATfqKQMIKLETSIQANKTIQNLKFNTETKLRSEEIAALRESM 588 domestic guinea pig
XP_024841058 525 GNPGRKIAEIQGKLATfqNQMMKLETSIQDNKTIQNLKFNTETKLRTEAMATLQESV 581 cattle
XP_023620241 553 GNPWRKIAEIQGKLATfqNQIIKLENSIQDNKTIQNLKFNSQIKMRMEEMATLKECL 609 little brown bat
XP_012661141 554 ESPGRKIAEIQGRLATfqNQIIKLENSIQANKTIQNLKFNTETKLRTQEMAALRESM 610 small-eared galago
XP_013219456 553 ESPGRKIAEIQGQLATfqKQMIKLESSMQAHKTIQNLKFNTETKLRTEEIATLRESV 609 thirteen-lined ground squirrel
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