Conserved Protein Domain Family
TMEM192

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pfam14802: TMEM192 
TMEM192 family
The function of this family of transmembrane proteins is unknown. In vertebrates, proteins in this family are located in the lysosomal membrane and late endosome. In Arabidopsis, a member of this family has been found to weakly interact with FRIGIDA, a determinant of flowering time.
Statistics
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PSSM-Id: 434223
Aligned: 27 rows
Threshold Bit Score: 224.459
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007231301  29 GPLISQDALESAIRREFQKLPTAWITGLLTAAHVAYVSVSVVLAVLCWlaedhseqcnavlngvdSQTVVLLGKVGLWLL 108
EDV93785      21 TDELLDPVLVSDNNGPYK-LKTVPAFSIHLLISTVISSVGIGLAVGFPadr-----------rceAYFIMLYLRATFWVI 88 
EDS36700       2 EDGQLDPILATEDDDGFRPLKTVPAFSFHLLISTCISLTGVILAATWQdsc-----------rceAYFIMLYMRAAFWLI 70 
ETN61777      26 TLGSQEPILATQENGDFEPFYTAPVFSFHLLISSIISVTGIALAATWDdtr-----------rceAYFIMMYLRVAFWII 94 
Q7QBM9        14 SKLYSPPCLMEGKPR-FRPIFVISLFSAHLFLAIAIITAGTVASVAGWpqpagd-----tdrsssVYFLIIYLRIVYWLV 87  Anopheles gambi...
ETN61775      14 PKLYSPPAMAKTDAK-FRPIFVIFMFSVQLLLAIAIVLIGLVALISGWtlpgd--------hasaLYFIIIYLRVGYWLV 84 
OXU20889       3 DEEYLQPVLVAQEQESFQKLDTIPIVAVPLIFGVALEITGIIFVSMWPeekn----------kcdTYFVLLYLHCAYWLL 72 
XP_019882176   3 EEQSFQPILSSQEEDNFQQLNTVPIVSMSLLLGISLEITGIVFVSVWPeeqn----------kcdTYFIYLYLHCAYWLI 72 
XP_001123128  26 DEEYLQPVLTSQEEH-FHKLDTVLITFIPLIFGVSLEITGIIFIAVWPeenn----------kcdTYFIYLYLHCAYWLL 94 
EFA05885      26 DPEHLQPILESYGT--FRPLNTVPVFSLHLLFTLALEIVAIVFAVQHPdeky----------kcrEYFIIIYIHAGLWFL 93 
XP_007231301 109 VFGFEWCVNHHHTTARRRGYLQFYRANQDLKRLPLFIHSAGNAALLVVIGPAPLLDKKVK-------------------- 168
EDV93785      89 TFLLDKFTKKQHDDLRLNGYHDFHRETKKQTDVPLQVVSLWNSALLAVQAAIHHYYGDGFgthc---------------- 152
EDS36700      71 TFLIDHYVKRHHEKLRLDGYHDFHRATTGHRAVPLQIVSLWNTFLLAVQALIQHYYGDSFaekcv--------------- 135
ETN61777      95 TYLVDYLVKKHHRALAMKGYLDFNRATKHHSTVPLQIVSLWNTFLLAIHTLMQHYYGEDFgtkci--------------- 159
Q7QBM9        88 TYVIHERNKAEFVRLAEPDF-DHYRALAVYRKAPLQIATLWNVILLTVQNQVRYLFPYERpdhgag------------ga 154 Anopheles gambi...
ETN61775      85 TYVIHERCKHEFARLLEPDF-DRYRSLSVYRKAPLQIVTLWNVILLTVQNQVRFLFPYESagpggntpgnpsngnkaega 163
OXU20889      73 IMVVDHLVKARHHTLRICGYLDFYQSTYQHIRTPLFISSLWNTIYLLLSVILHHTHKNNYenycr--------------- 137
XP_019882176  73 VMVTDHVVKARHHKLRIDGYLDFYQITYRLIRIPLFITSLWNTCYLLLAVILHHTHKIDYeryck--------------- 137
XP_001123128  95 IMLTDHLVKRKHHKLRIYGYLDFYQSTYQQIRTPLFIASLWITCYLLLAVFLHHTHKVNYeqycr--------------- 159
EFA05885      94 TLIVDQIARRKHYNLRILGYLEFYNKTHIHHRLPLYVVSLWNAVIMIIQAIAQQFYPDNFaekci--------------- 158
XP_007231301 169 ----NLSVYLLLCIICLELLFTLICLIVYTVRVARFNSQRPGPDINEEEKSHAYSNnisgtHAHTETGFRD-GSSLEEVV 243
EDV93785     153 aegwLSPITYVTVFNVAENLVLTASHSFYINKVRKFNKAKLSPDVLRGDN-----------RATGSLGLMQpGGDTAELL 221
EDS36700     136 vvgfLSPIVYITMFCSLETFVLALVNGSYIGKVVRFNRTAAPPDALQGSRG----------HSSGSLGLTQrGLSTTELL 205
ETN61777     160 vlgwLSPIVYITAFSCLETGVLSIVNGSYIAKVRRFNRTAAPPDALQDNRG----------MRGGSVGLTQrGLSTTELL 229
Q7QBM9       155 lnpaITPQVFVVVVCALELLVLLCFYVPLV---------RILIDIRRGEGHGKVTDlryrrMTDTELA----EQPIEWQL 221 Anopheles gambi...
ETN61775     164 lnpaITPQLFVMVVWGLELLLQLFFNVPFI---------RALNEIRNAEGLDKETDlryrrMTDTEIE----EQPFEWQL 230
OXU20889     138 asewFTPLNYILLLTTFELIIIVPVYINYIKRVVRFNRTKPPPDVTREEWLMSFTQds----yTGEVGYHQrGLNLAELL 213
XP_019882176 138 tsewFTPLNYIFVLTNLELVIIVPAYINYIKRVMRFNQLRPLPDVTRDEWLSSFTQds--ySGMGEIGYHErGTNMEELL 215
XP_001123128 160 asewFTPLNYIVLLTTLELIIIVPVYINYIKQVLRFNRLRPPADVAREEWLSSFTQdt--yAGSNEVGYHHrESNLEELL 237
EFA05885     159 nggtMSPIGYLCALITFEFCLIAGININYIFKVQRFNKQKAPPDVQREEWNASMS------PEATEIGSPLrGEKLYDFL 232
XP_007231301 244 EKQADLIEYLKQHNTLLSRRILSL 267
EDV93785     222 EKQADLIAYLRDHTHKLNQKLHQM 245
EDS36700     206 EKQADLINYLKDHNLKLNQKIMQM 229
ETN61777     230 EKQADLINYLKDHNLKLNQKIMQM 253
Q7QBM9       222 ERQAVLIKRLRAERDRLQREAKLL 245 Anopheles gambiae str. PEST
ETN61775     231 ERQAELIKHLRMEHDQLQRKAKAY 254
OXU20889     214 EKQADLIRYLRDHNVRLSHRMMLL 237
XP_019882176 216 EKQADLIRYLRDHNINLSHRIMLL 239
XP_001123128 238 EKQADLIRYLRDHNVKLSHRMMLL 261
EFA05885     233 QKQADLIRFLKEHNAKLGEKLMVL 256
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