Conserved Protein Domain Family
Neurochondrin

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pfam05536: Neurochondrin 
Neurochondrin
This family contains several eukaryotic neurochondrin proteins. Neurochondrin induces hydroxyapatite resorptive activity in bone marrow cells resistant to bafilomycin A1, an inhibitor of macrophage- and osteoclast-mediated resorption. Expression of the gene is localized to chondrocyte, osteoblast, and osteocyte in the bone and to the hippocampus and Purkinje cell layer of cerebellum in the brain.
Statistics
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PSSM-Id: 336138
Aligned: 5 rows
Threshold Bit Score: 475.942
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9VI25     2 TDVPEPVRKCASLLKGTKSDTEKFAALFMVTKLVKGKDCNAAGKKLLF---EAIGFPFLKKLLVSKD---LPNDC----P 71  fruit fly
O35095    30 ESRNPTLERYLGALREAKNDSEQFAALLLVTKAVKAGDIDAKTRRRIF---DAVGFTFPNRLLTTKE---APDGC----P 99  Norway rat
Q5ZIG0     4 GPGAATLKKCLEVLRDARNDSEQLAALLLVTKAVRAGDLDSKTRRQIF---DAIGFTFPNRLLSSRQ---APPGC----P 73  chicken
Q5E911     7 eERSPSLDDCLKLLKGER-DEQRLAGLLLVTKFCKNDDIVSLNK--VY---EAVGTHFLDRLFRTGS---GSGDGv--dN 75  thale cress
ESA43169  18 TGQPDPIQNAQTLLRAKD-DTSRFVGLALLKSVLDNSEELRNNQEAVRglwKSVPSKFLDRLIKTGSrqqSQSEGggnkN 96 
Q9VI25    72 PLVYKSVALSILTCFCQ--EEELATHKDIIDAIPTLLEIVEQADDEdyeDNLIVVSEAYSCLKSIA-SHEPGQQALLATG 148 fruit fly
O35095   100 DHVLRALGVALLACFCS--DPELASHPQVLNKIPILCTFLTARGDPddaARRSMIDDTYQCLTAVA-GTPRGPRHLIAGG 176 Norway rat
Q5ZIG0    74 EHTFRALGLTLLACFCT--EPELAGHSQVLNKIPTFADVLLSPCQP---DCTSMVDDAYQCLAAVL-ATPRGPREMVTKG 147 chicken
Q5E911    76 RDVYLQISITVLAAFCR--VPEIASSEEMVSRIPLILEVMSKGIT------TNMLEDCYELLYLVStACEAGLMTLINSG 147 thale cress
ESA43169  97 ARDMLDLAVAIIHTFAAlvPEDNKRDSRFTERIPHLVACLLNCSN-------ETTKLVLETLSALV-TTPDGAKAFIALD 168
Q9VI25   149 AIPKMSQIYSA---QSFQTDEALHLIVLLVKQFGVVSWP-EDPTAFHALIQRIALDMETDDTERKYELCRILADILITCR 224 fruit fly
O35095   177 TVSALCQAYLG---HGYGFDQALALLVGLLAAAETQCWK-EAEPDLLAVLRGLSEDFQRAEDASKFELCQLLPLFLPPTT 252 Norway rat
Q5ZIG0   148 AASALCQAYVN---GGYGSERALALLLGLLAVSEAKCWQ-RDAPHLLAVLSKLSEEFVRAEDGSQFELCELLPRFIPLS- 222 chicken
Q5E911   148 GLRVIAPQMSElpdGSHAMEVAIKILQLLVSKLDCGSMTiERFLELSLVIAAVARQFAVLHNALKFEALHLLSAVFSSEY 227 thale cress
ESA43169 169 DVTTLIEIAPS---QPLVLDIFFYAWLNATSSSVSSSAE-DKDLLRTKIDHTITALVSSFKGTDAVTLLDFLANLLPRLe 244
Q9VI25   225 REIvins---legqIWPESLFKGCGDILKAKIGPKQRDPALHLIATTLHV---LGIQWAFMDEQ---------------K 283 fruit fly
O35095   253 VPP-----------ECHRDLQAGLARILGSKLSSWQRNPALKLAARLAHA---CGSDWIPVGSSg--------------S 304 Norway rat
Q5ZIG0   223 -PPlaev---sqgsECVRQLYKGLASILGSKLSQSQRDPALKLAASLTQA---CGSEWIPAGSTg--------------S 281 chicken
Q5E911   228 SELlheplrsmpdnNWADYMRTGVVAILQNRVAPSEKLHALILAENMMSI---LGEKWLLGGVKlpnv-------dipaD 297 thale cress
ESA43169 245 pqvs------pqnpKWLPTLNLFIRNLVSSRPTPAGRAAYTNLSAALLEVypsVAPQLLFTDDPsgkgtskanspsddnK 318
Q9VI25   284 TFFLQLLQLGAIEVRMQMDEkk------------lETTFKQAELLTCCFSILEHCIEYMAT----DQLDLE-----PKEK 342 fruit fly
O35095   305 KFLALLVNLACVEVRLALEE---------------TGTEVKEDVVTACYALMELGIQECTRc---EQSLLK-----EPQK 361 Norway rat
Q5ZIG0   282 KFLALLVNLACVEVRLTLEEpe------------pLEVEGKKEVVTACYVLIEMGIQECLKe---EESLLD-----EAQR 341 chicken
Q5E911   298 RCLLLVLESSHVEISVLLNDlaykkyeapkdnstaEDILLKQRYLPIVFSLVEKIIKYISSagenEGTLSD-----EAVF 372 thale cress
ESA43169 319 PFSYLLISILLIDIRSTAPTllsq--------lnsPSYPQSSRRLSSAFNIISHYLGFLLRsl-dPSSSSDsllpdPTFL 389
Q9VI25   343 QTTYTALKGAFNQVLAVLTRVSQ--------------------------------DKIRESsnpkdkkFVFAIVKVLSAW 390 fruit fly
O35095   362 VQLVSIMKEAIGAVIHYLLRVGP--------------------------------EKQKEP-------FVFASVRILGAW 402 Norway rat
Q5ZIG0   342 MQLMRIMEEAFGAVVFYLRQVKE--------------------------------EELQDP-------FVFASVRILGAW 382 chicken
Q5E911   373 QKVIKILNETVGAVFEYLRDAKE--------------------------------HGIKKGt------DLLASVRVIGSY 414 thale cress
ESA43169 390 LKLRTSLSETFSLTLEFLRDRYDasvagamgldpsarsstahdsasgashltlswESMKDSveq--dpLILAAIRALAIW 467
Q9VI25   391 LAQETTA-MRPAIYKLLPFMLKVANESFQELKTWRAGTRE------------GEPPIDVLRIMLPALCHFAVEEEARRVL 457 fruit fly
O35095   403 LAEETSS-LRKEVCQLLPFLVRYAKTLYEEAEEASDISQQvanlaispttpgPAWPGDALRLLLPGWCHLTVEDGPREIL 481 Norway rat
Q5ZIG0   383 MAEETSS-LKQEICELLPFLVRYARKLFKEGGPAENLPQTaglvs--sdssiLGQ--DALRFLLPGFCHLTAEDRPRDIL 457 chicken
Q5E911   415 LAETPVA-CKEQVQDLLDYMLSVKGEDESS-------------------------PFLSTCFLLPMLCQITMNAEGCKLL 468 thale cress
ESA43169 468 LREDDNEqLRKEASGLGDLFIDLYRHSCHPPDPTKGD------------------RLDFRRPVLMAWEGLVEERKGVESF 529
Q9VI25   458 FTHKQDEVLLESLEFYFSIahwkrppipraerLKRMNEPDPVPTpeqQAEMkvarsAIVALCNILMNFTVLEPKK-AEDG 536 fruit fly
O35095   482 IKEGAPSLLCKYFLQQWEL-------------TSPGHDTSVLPD---SVEI-----GLQTCCHIFLNLVVTAPGL-IKRD 539 Norway rat
Q5ZIG0   458 ISEGAPALLCDYFLHQWGV-------------LTSQ------PGsltSTEM-----SLQTLCGIFLNLVVTAPNL-IRQE 512 chicken
Q5E911   469 AYSRGDVAVVE------CL-------------IKLIERCGESVDe--DR-------SIFLACDTIMNILLKREEIsPPEI 520 thale cress
ESA43169 530 LANGGWQALAD------DL-------------VGILQSTTTSTSsssSASL---------------SSSGEVVVVdEAEA 575
Q9VI25   537 PTFANLLKFVVENLPELKDTPDNLVIHGNLAVLGLLLLK---QQSKKVKQNDFSICRYIQATIRFLWDAYNIDESNDPTA 613 fruit fly
O35095   540 ACFTSLMNTLMTSLPSLVQQQGRLLLAANVATLGLLMARllsTSPALQGTPASRGFFAAAILFLSQSHVARATPGSDQAV 619 Norway rat
Q5ZIG0   513 KTFSSLMDTLLKSLPFLLPQKDHLVLAANIATLGLVMARilsSSAVLQKTGSAKEFFRATICFLSQAHTAQADPGSHGLA 592 chicken
Q5E911   521 STFASLLKALAY----------------------------------------------------------WADGSNDHSV 542 thale cress
ESA43169 576 ARGTEIVRVLLQ------------------------------------------------------------------VA 589
Q9VI25   614 LVVSIAYKGYWSDLSELW 631 fruit fly
O35095   620 LALSPDYEGIWADLQELW 637 Norway rat
Q5ZIG0   593 LAVSPAYVSAWDDIRELW 610 chicken
Q5E911   543 VMMAASICSLIFDFTSEd 560 thale cress
ESA43169 590 ELERPGPKEEWLDLVTkv 607
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