Conserved Protein Domain Family
AKR_CeZK1290-like

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cd19135: AKR_CeZK1290-like 
Caenorhabditis elegans ZK1290.5 and similar proteins
Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Statistics
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PSSM-Id: 381361
Aligned: 13 rows
Threshold Bit Score: 404.784
Created: 20-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens delta(4)-3-ketosteroid 5-beta-reductase (AKR1D1,3BUR) binds cofactor NADP and testosterone.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           ###                        #   ##                        #    
Q09632          1 MIPTTVLSNNVEMPLIGLGTTHs--GGYYHDAVLHSIKKcGYRLIDTAKRYGVEKQLGIAVKNCSVPREEMFLSTKLWPV 78   Caenorhabditi...
NP_001086970    5 KIPTVPLSSGHHIPLLGLGMSHs--GGYSHNALLYALTTcGIRHIDTAKRYGNEVMVGKAICESGVKREELWLTTKLWPG 82   African clawe...
EEN62921        6 STECVVLSNGVKMPILGLGTSHh--GGFSQSAIVYALRDcGIRLIDTAKRYGCEEQLGAAIKQSGVPREQIFVTTKLWPL 83   Florida lancelet
XP_002737564    5 KTKTVRLSNGVKIPILGLGTSHi--GGYCHSTVVHALKDcGYRLIDTAARYKCEEAVGKAIRESNVPRKDIFLTTKLWKS 82   Saccoglossus ...
XP_006009973   10 VIPAVPLANGQKIPILGLGTSHh--GGYSHNAVVFALKEcGICHIDTAKRYGCESLLPEAVKESGLNREDLWMTTKLWPS 87   coelacanth
EFX80255        4 LDNFVRLPNGVRMPIFGLGTSHg--GGYDQESVIFALREcNYRLIDTARRYGCEHLIGKAIKESGVSRESVFIATKMWPT 81   common water ...
ETV73186        9 ATDTLRLRNGVEMPFLGLGTSHn--GGYSHDAVVVSLRH-GLRAIDTATRYGCESQIADAIAASGVRRADVFITTKLFYD 85   Aphanomyces a...
XP_013403334    4 LTKTVVLSNGLHMPIFGLGTSHl--GGYSHSAVVYALKNcGYRHIDTAERYGTEDKLPLAIKESGIHREDIFLTSKLWPA 81   Lingula anatina
XP_015919345   11 GPREVELSNGVKIPTLGLGTSHs--GGYSQEAVVYALKVcNYRLIDTAKRYGCEEFLQAAIHLSGVPREDIFLTTKLWCT 88   common house ...
KYO19524        7 GGPALPLANGLSIPVLGLGTSHv--GGYSHEAVVYALQKcGIRHIDTAKRYGCESLLQKAIKESGVKREDLWITTKLWHS 84   American alli...
XP_022101738    4 EMEHLQLSNGIQMPVLGIGTSRwfvGGYSDEAMVYALGHcRVRHIDTARRYRCEDLVGASLRKSGVTREQVFITSKLWPS 83   crown-of-thor...
NP_001278275   12 SCPAVPLHNGLNIPILGLGTSHy--GGYSHEAVLYALQEcGIRHIDTAKRYGCEEALGKAVTESGVQREELWITTKLWPG 89   zebrafish
OLP81828     2078 GDAEVRLANGVEMPVLGFGTWQl-iGQQCFEATLHALKI-GYRHVDTAQSYGNEAEVGRAVAAAGLPRHELFLVTKLSNP 2155 Symbiodinium ...
Feature 1                                     ##                                    ##            
Q09632         79 DCGd-EVYNAFQTSCEKLQTDYLDMYMIHMPqlpdwivn-qketkekTWRQMELLYEDEHVRSIGVSNYsIEDLDELLEf 156  Caenorhabditi...
NP_001086970   83 DYGyeNAIQSCLDSCKRLGVDYLDLYLMHWPdahvpgks-arearaeTWQALEELHEKGICRSIGVSNFlIHHLDQLKEd 161  African clawe...
EEN62921       84 DYGyeSTKTAFKESCKRLGVDYLDLYLIHWPdcprgkgqdnrtiraeTWRALEDLYSKGLCRAIGVSNFlVPHLEQLIQd 163  Florida lancelet
XP_002737564   83 ELGykKTIDAFSASLQRLKVEYIDLYLIHWPvcphgsnn-vkslraeTWKAMEELYKQGLCKAIGVSNFeVSHLRDLEEt 161  Saccoglossus ...
XP_006009973   88 DYGyeSTKKACLESCKRLGVDYLDLYLMHWPdgclpgks-krevraeTWKAMEELYDEGMCRSIGVSNFlIQHLEQLREd 166  coelacanth
EFX80255       82 DYGteSAIRAAKSSLTRLDTDYLDLYMMHWPlcpssvdn-vrstldnAWRGMERLLDEGTCRSIGVSNFsIQDLIDLMEs 160  common water ...
ETV73186       86 DYGydNAIRSAEASLARLRTDYIDLYLLHWPgtpstah--nrqiradTWRALVHLYSVGKVRSIGVSNFlHSHLEQLQAd 163  Aphanomyces a...
XP_013403334   82 HYGyeKTKAAFHNSLQKMQTDYLDLYLLHWPycplaekd-pkhtlheSWRALEDLYDEGKIKAIGVSNFlIPHLEDLLEe 160  Lingula anatina
XP_015919345   89 DYGasTTRKAFYGSLKRLGVDYLDLYMMHWPlcvsscpn-kkqtleeTWRELELLYDEGLSRCIGVSNYgIEDLESLLDt 167  common house ...
KYO19524       85 DYGyeNTKQACLESCRRLGVEYLDLYLVHWPdaqvpgks-srevraeTWRAMEELYATGMCRSVGVSNFlINHLEQLKEd 163  American alli...
XP_022101738   84 EYGyrKTRAAFQDSLQQVGVEYFDLYLLHYPsspegtd--tkqliseSWKALEEFYSQGLCKAIGVSNFqISDLKNLEEt 161  crown-of-thor...
NP_001278275   90 DYGyqSTKQACRDSCARLGVDYLDLYLMHWPdsmvpgrs-sqevrleTWRALEELYDEGLCRAIGVSNFlIPHLNELKDc 168  zebrafish
OLP81828     2156 EEYt-ALRPRFEAQLRELRTDYLDLYMLHSPgpgass-----eatraAWQSMEQLYHEGRIRALGVSNFgPEELESLLSf 2229 Symbiodinium ...
Feature 1                      #                                #######           #           #   
Q09632        157 a-----sILPHANQVELHPWFh-------QADLKNYCDELgILTMGYCPLAKGk----yLEDETLCKIASKYQKSPAQIC 220  Caenorhabditi...
NP_001086970  162 c-----nVVPHLNQVEYHPFQk-------PQELVDYCRRNnIVFGGYCPLAKGq----aLNHPTIQKIAKNYGKTPAQIC 225  African clawe...
EEN62921      164 c-----tVVPHVNQVEYHPYQn-------PKDLMRFCQAHsIAVEGYCPLAKGs----aLKEPAITTIATKYQKTPAQIL 227  Florida lancelet
XP_002737564  162 w-----dIIPHVNQIEHHIYYr-------PMELIQYCKDKgICVEGYCPLSQGl----aLEEPIIQELANKYKKTKSQIL 225  Saccoglossus ...
XP_006009973  167 c-----dVIPHVNQVEYHPFQr-------PQELVNYCRSKeIIFEGYCPLAKGe----aLTHPNVIQLAKKYNRTPSQIC 230  coelacanth
EFX80255      161 c-----sVVPHVNQCEFHPYQn-------PKELRAFCRENnIEFQGYCPLANGm----iLKEPPVEKVAQSAGRSPAQVL 224  common water ...
ETV73186      164 slasgisERPHVNQVECHCFNh-------PVQLIAYCRQHgIAFEGYCPLAKGq----lLIEPTIVDMAKLYACTPAQLC 232  Aphanomyces a...
XP_013403334  161 c-----rIRPMVNQVEHHPYNn-------EKALFQFCKDNnIQYEGYCPLAKGr----iLNEPIVVEIAQQHNKTPAQVL 224  Lingula anatina
XP_015919345  168 a-----sIAPQVNQVEFNPFQn-------PSELKEFCVENkIQVEGYCPLGKGk----lLGEKAVLQVARRCGRTPAQIL 231  common house ...
KYO19524      164 c-----eVTPHVNQVEYHPFQr-------PQELLDYCRSRnIVFEGYCPLAKGe----aLAHPKIIQLAKKYDRTPAQIC 227  American alli...
XP_022101738  162 w-----nVVPHVNQLEVHIFNy-------PEKLIEYCRRLgMQIVAFSPMAKGk----aLAHPRVMELATKYKKVTSQIL 225  crown-of-thor...
NP_001278275  169 g-----gIVPHVNQVEFHPFQq-------PMKLVEHCRKEnIVFEGYCPLAKGq----aLTHPHILELAKKYGRSASQIC 232  zebrafish
OLP81828     2230 a-----tVPPVYVQNKFSVYTpgeqrvnhDVSIMSYLKDKnIVMMGYSVINPWpgvippLQDPHVTAMAARKQKTPSQVL 2304 Symbiodinium ...
Feature 1                    ######  #  ##                    
Q09632        221 LRWSIQQNVPTVPKSTDCRRLKENTNVFDFeLSAEDMNTLNSFS 264  Caenorhabditis elegans
NP_001086970  226 IRWSIQNGVVTIPKSTKEERIQENCEVFGFvLTDEDVLTLNSLH 269  African clawed frog
EEN62921      228 IRWSIQNGVVTIPKSTKEERIRENCQVFDFsLSREDMAHLDSLH 271  Florida lancelet
XP_002737564  226 IRWNIQNDVVTIPKTTKESRVHENFQVFDFeIHEEDMQRVNSIH 269  Saccoglossus kowalevskii
XP_006009973  231 IRWSIQNGIITIPKSTKEERILENCQVFDFsLKKEDMEYLDSLH 274  coelacanth
EFX80255      225 IRWSIQNGVVTIPKSIKKERIKENSQVFDFeLSPEEMAELDTIP 268  common water flea
ETV73186      233 IRWNLQHGYICIPKSTKPERVVENACVFFFsITPGDMTKLDALH 276  Aphanomyces astaci
XP_013403334  225 IRWSLQDGIVTIPKSTKESRVLENCQVFDFtLSDSQMTTLHGLH 268  Lingula anatina
XP_015919345  232 IRWSIQNEVIAIPKSTQIERVKENCKIFDFhLQENEMSILNDLH 275  common house spider
KYO19524      228 IRWSIQNGVVTIPKSTKVERIQENCEVFDFtLAEDDVAILNGMH 271  American alligator
XP_022101738  226 NRWVIQHGCATIPKSTKCHHVEENCKIFDFvLTEEDMQTLDAIH 269  crown-of-thorns starfish
NP_001278275  233 IRWSIQNGVVTIPKSTKPDRIYENCQVFGFtLTSEDMAYISDLH 276  zebrafish
OLP81828     2305 HRWALQLGAGVIPKSASAARIEENARLFDFsLSDTEMRLLSGMV 2348 Symbiodinium microadriaticum

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