2Z5D,1YF9,2ONU


Conserved Protein Domain Family
UBCc_UBE2H

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cd23797: UBCc_UBE2H 
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 H and related proteins
The E2H subfamily includes mammalian ubiquitin-conjugating enzymes E2 H (UBE2H), yeast E2 ubiquitin-conjugating enzyme 8 (UBC8/GID3), and plant ubiquitin-conjugating enzyme E2 4-6 (UBC4-6). They are ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2H (also E3-independent, EC 2.3.2.24) transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro, UBE2H catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. It might also ubiquitinate histone H2A. Saccharomyces cerevisiae UBC8 is required for the adaptation to the presence of glucose in the growth medium; it mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium. It is also required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1).
Statistics
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PSSM-Id: 467417
Aligned: 51 rows
Threshold Bit Score: 206.659
Created: 10-Aug-2017
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: active site cysteine [active site], 1 residue position
Conserved feature residue pattern:CClick to see conserved feature residue pattern help
Evidence:
  • Comment:forms a thioester with ubiquitin or ubiquitin-like proteins
  • Comment:serves as the point of attachment of ubiquitin prior to transfer to cellular target
  • Citation:PMID 9497353
  • Citation:PMID 9705497

cd23797 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd23797 is a member of the superfamily cl49610
Sub-family Hierarchy
cd00195UBCc_UEVcd11685UEV_TSG101-likecd11686UBCc_UFC1cd23790UBCc_UBE2A_2Bcd23791UBCc_UBE2Ccd23792UBCc_UBE2Dcd23793UBCc_UBE2Ecd23794UBCc_UBE2F_UBE2Mcd23795UBCc_UBE2G1cd23796UBCc_UBE2G2cd23797UBCc_UBE2Hcd23798UBCc_UBE2Icd23799UBCc_UBE2Jcd23800UBCc_UBE2Kcd23801UBCc_UBE2L3cd23802UBCc_UBE2Qcd23803UBCc_UBE2Rcd23804UBCc_UBE2Scd23805UBCc_UBE2Tcd23806UBCc_UBE2Ucd23807UEV_UBE2Vcd23808UBCc_UBE2Wcd23809UBCc_UBE2Zcd23810UBCc_BIRC6cd23811UBCc_ScCDC34-likecd23812UBCc_ScPEX4-likecd23813UBCc_UBE2Ncd23814UEV_AKTIPcd23815UBCc_SpUBC14-likecd23826UEV_Morgue-likecd23828UBCc_TcUBE-likecd23833UBCc_ApmR795-likecd23837UBCc_UBE2Ocd23955UBCc_invertebrate
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
2Z5D_A     28 RRMDTDVIKLIesKHEVTILGg----lNEFVVKFYGPqgtPYEGGVWKVRVDLPdkYPFKSPSIGFMNKIFHPNIDEaSG 103 human
2ONU_A      5 TRKQCDFTKLImaGYDLELNNgs---tQDFDVMFHGPngtAYEGGIWKVHVTLPddYPFASPSIGFMNKLLHPNVDEaSG 81  Plasmodium falcipa...
NP_597216   6 PRIKNEIQKLYnaNYEVRMIEgk---qTQMEVLINGPedsPYSGAKYIVNILLPdnYPFKSPSIGFTTRIFHPNVDEaSG 82  Encephalitozoon cu...
Q9VGD6     16 RRLDRDVNRLLasGYRTTVDDd----mTNLNVCLEGPlgsAYEGGIWTVNVTMPqdYPLTAPRVRFVTKILHPNIEFiTG 91  fruit fly
CAK67823   11 KRKERDIAKLMmsNYHVEQCPqn---pYNFKVNINGPsdsLYAGGVYTINVLLPeqYPYKSPSIGFLTKIFHPNIDEaSG 87  Paramecium tetraur...
EER05564    6 NRKHTDFARLMraGYEVDVDPesknvtQDFSVLFYAPaesPYKGGVFRIHVELPeqYPFQSPSIGFKNRIYHPNIDErSG 85  Perkinsus marinus ...
CBY39826    9 KRMDTDVMKLIesKHEVNLIGds---lNCFQVKFCGPsdsAYKGGVWRIRVELPekYPFKSPSIGFLNKIFHPNIDLgSG 85  Oikopleura dioica
EPR56937   17 NRKQCDFTKLMmaGFDLELNNds---tQDFHVVFHGPkgtVYEGGVWKVHVTLPddYPFASPSIGFMNKMLHPNVDEaSG 93  Toxoplasma gondii GT1
NP_500245  10 RRIDCDVVKLIshNHEVQIVNg----cSEFIVRFHGPkdtAYENGVWRIRVDMPdkYPFKSPSIGFLNKIFHPNIDEaSG 85  Caenorhabditis ele...
PVC51953  375 IRKQCDFTKLLmaGYDLELVNgs---tQEFNVTFHGPngtIYEDGVWQVHVILPddYPFASPSIGFMNKMLHPNVDEsSG 451 Theileria orientalis
Feature 1       #                                                          
2Z5D_A    104 TVCLDVINQTWTALYdLTNIFESFLPQLLAYPNPiDPLNGDAAAMYLhrPEEYKQKIKEYI 164 human
2ONU_A     82 SVCLDVINQTWTPLYsLVNVFEVFLPQLLTYPNPsDPLNSDAASLLMkdKNIYEEKVKEYV 142 Plasmodium falciparum 3D7
NP_597216  83 SICLDVLNQIWSPIYdLLNIVDILLPQLLSYPNAaDPLNCEAGSMYLnnREKYNEVVRSYV 143 Encephalitozoon cuniculi GB-M1
Q9VGD6     92 LVCMNVLKQAWSSSYdLVNIFETFLPQLLRYPNPhDSLNHRAAAIMKhsEQLFREHVILCM 152 fruit fly
CAK67823   88 SVCLDVINQAWSPMYdLMNVFEVFLPQLLNYPNPsDPLNPDAASLLIrdKPRYEKKVKDMV 148 Paramecium tetraurelia
EER05564   86 SVCLDVINQTWTPLYsLVNIFDVFLPQLLAYPNPsDPLNPEAAALMLrdKTAYDYKCQEYV 146 Perkinsus marinus ATCC 50983
CBY39826   86 SVCLDVINQTWTPLYdLSNIFDTFLPQLLMYPNPhDPLNGDAAGLYLhqPEEYKKRVRDYV 146 Oikopleura dioica
EPR56937   94 SVCLDVINQTWTPLYsLVNVFEVFLPQLLTYPNPtDPLNSEAASLMSrdKRLYEEKVREYV 154 Toxoplasma gondii GT1
NP_500245  86 TVCLDVINQAWTALYdLTNIFDTFLPQLLTYPNAaDPLNGEAARLYIhkPEEYRRTCREYV 146 Caenorhabditis elegans
PVC51953  452 SVCLDVINETWTPIYsLVNVFDVFLPQLLTYPNPsDPLNNEAAALMMldKTSYEEKVREHV 512 Theileria orientalis

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