Conserved Protein Domain Family
7TM_GPCR_Srz

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pfam10325: 7TM_GPCR_Srz 
Serpentine type 7TM GPCR chemoreceptor Srz
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srz appear to be under strong adaptive evolutionary pressure.
Statistics
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PSSM-Id: 431214
Aligned: 54 rows
Threshold Bit Score: 144.27
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O45618        28 VLIFIILFLFYILVFPFYVYVNKVNKERDKNAFVFPITNHFFEM---TKNAFIGYIYFPVNCFFAVALIYk--------- 95  Caenorhabditis ...
Q65CL6        13 STRLLYIPVLHIILLPFYVYANKINRQRDEKAVVFPITNYFYKM---VKITFIPSLLTHIIGFIDYFLLPsg-------- 81  Caenorhabditis ...
O76625        31 SIVLIPMYLLYILLLPFYIYVNRINRRRDENVLIFPITNVFYKM---VIFTLFVVVAKYIFFISFQVFAVlpn------- 100 Caenorhabditis ...
5_pfamImport   1 EYVANFLIVAYFVFLPFYVYVNKVNRRRDEKMIIFPITNHFYKM---VMISVIFLIFYTALSTLVEHGNLk--------- 68 
Q688C1        23 IEQYKPLVILYFILLPFYIYVNKVNRRRDEKMVIFPITNHYYNM---LKLTLPIWTCFCVSVYFFHRGHK---------- 89  Caenorhabditis ...
Q9TZ00        20 FISVFVFLVIYLILFPFYMYVFNYNRKQDEKTFMFPIIDHIFKM---NKVAYILIVCLIICIIKTCVYFStlpsnfqlda 96  Caenorhabditis ...
Q9N5W5        25 LLPIPCFLIVNVLITPFYMFVYKQNIKRDEKMPIFPLMNHFYKM---TRTTTVIILFIILGLFMCFFTQSk--------- 92  Caenorhabditis ...
Q5WRL4        11 SITNCVFMVISFLIYPFFVAVFRKNHAKDKGKAIFPVFNHFYKSikkIQIVNAIYILYFFFTLFMAFFGA---------- 80  Caenorhabditis ...
Q93869        28 GIPLIFLWFCYLSIFPFFLAVFHLNKEKEKETAVYHIIYYFVVT---VKRMYALQLFQLTIFPAIAYFET---------- 94  Caenorhabditis ...
Q86D22        28 ALLGGICAIVFCVIFPFYIVVYRTNRQRERSTPIFPIIKHIHST---VVRTYFLLFGCFVIIIISFALSS---------- 94  Caenorhabditis ...
O45618        96 ----kSFFVVPFLIVMVIIIFCLHVITQIFYLLIIVLAFERFLLYFLKSTERTLQIIQTFIHRHFNSFYAIFAIKDALYI 171 Caenorhabditis ...
Q65CL6        82 ---dkPFYWKLLNFISFCSLFAFHINNTVFHVLIMMMTLVKFLVYFFPSTEKCSLSVQSFFHKNLKLVYLTLTIKDLIIR 158 Caenorhabditis ...
O76625       101 --mseTIYSYVSLFAYEFCLLLLRVNNAVLDFFLIISPIVRFLVYFFPSTEKPITVANTHIYKILAYLYVILIIKNFFFF 178 Caenorhabditis ...
5_pfamImport  69 ----eGNILAIIGFMILTVFYTICMSIQVFQLFIVALAIERFLLYFCPSTEKLITLVQNYVHQRIKCIYISCAIKDLVIF 144
Q688C1        90 --------NRISTYTLILTSYALYLFNQVFRISIIALSFERFLVYFFPTTEKNIILVNSYIIKRIKYIYLGLFIKDIICI 161 Caenorhabditis ...
Q9TZ00        97 deemvDTPQLFTNLAIVASLLTLFLMNQLFHCFTFLMAVERFTIYFFPSSEKIVLKFQTYVTKHIKFAYCLLIVKDILAL 176 Caenorhabditis ...
Q9N5W5        93 ----nRIFALASLFPVLLLMESLVILTQVYHWLIFLLAAERAIIYFFPSSEKRVLSILKSIHANIHYIYIY----HLLII 164 Caenorhabditis ...
Q5WRL4        81 -----TFFVFLIPVLLIVFPLVTGLMHDVNEFLLGLLSIQRFCLYFMPNYEKYLNISVEALNVVVRNLYICFIIKSVMLI 155 Caenorhabditis ...
Q93869        95 -----YWIQVVILIMYPPTGWILTLTNRVNQSFMGILAIQRFTLYFYPSSEKYVKITPTTLQWIIFIEYLYFLAEPLLLV 169 Caenorhabditis ...
Q86D22        95 ------MLLILVFLIAILSAAYLVMVSKVNHLLMGILAIQRFGICFHPRSENYLKITHETLNWIVAIGYAYFVLEKVVSF 168 Caenorhabditis ...
O45618       172 ISWLVSSGNYQ-------FWLEFSYMTVYFATLIFIFTSAFFYIPIMISVRKLTN-LTSAKQSNPEKYIFWQTIVIFICK 243 Caenorhabditis ...
Q65CL6       159 YSIGDRNAH---------KRLYRISYITYYGFNVLLLISALLYIPILINIRKHSY-LPSFQEHHPQRYIFWQTIVVFIFK 228 Caenorhabditis ...
O76625       179 LMEVINEDPVVeleltgwEWINYIPYVPFYSFHVLIFLSVLLYIPIMINIRKHSH-LASYQQNHPQRYIFWQTVVVFIFK 257 Caenorhabditis ...
5_pfamImport 145 ILPYSSD-----------PEVKMITYAMHYSMEILIILSSLLYLPIMISVRKLSH-LASAEQNHPQRYIFWQTMVVLIFK 212
Q688C1       162 VLHAVTFFDDShp---yyLIWSVFFITIFYTMHILLFLSALLYIPILISIRKLSH-LASSQLNNPQRYIFWQTMILFVFK 237 Caenorhabditis ...
Q9TZ00       177 IYALWKHVNLKg-----gIDVYFIYFAFYYTIFFLPVLASFLYIPIMISIQKRAH-LPSFQENEPQKFIFWQTIAATVVK 250 Caenorhabditis ...
Q9N5W5       165 LMLKIGFRRGRmfknaywYNPELLFWSWHMLGYILLIISALLYLPIMISVRKLSH-LASAQENKPQKYIFWQTMIVVIFQ 243 Caenorhabditis ...
Q5WRL4       156 ILPYIYT-----------ANILTYTTLILLFQNLFVFLCALLYIPILISIRKARH-LSSFKLHRPQNYIMYQLLLALFAK 223 Caenorhabditis ...
Q93869       170 YFAHISNLKHLn------YQIDMYF---FFGEHIFLILSNSLYVPIIISIRKLTH-LTSAQQNKPQKFIMCQCLLIVVEK 239 Caenorhabditis ...
Q86D22       169 WMYFCEF-----------EDVKVFYMFSYISMHLFLLISALAYIPLILNIWKTSKhLKSAQLHKLQNHIMCQFLLIIASK 237 Caenorhabditis ...
O45618       244 SIAIPIIVDFFI---HSESTIGVlv-dFLIISDLVTTPLIIQLSYLGCNK 289 Caenorhabditis elegans
Q65CL6       229 SITILSVIFHAY---YSIDSLIIrl-eDETAIEMITIPLIIEMSYLGCNK 274 Caenorhabditis elegans
O76625       258 SMTLPIIIMYKY---FNYNNFVKlt-sEETGIEEITIPLVIELSYLGCNK 303 Caenorhabditis elegans
5_pfamImport 213 SLTLPASAIALTn-dGTLTETQN----AQMNIEIFTIPLIIMLSYLGCNK 257
Q688C1       238 SMSFSMVVLQM----QDIEDIFLnv-iSESILESATIPLLIVISYLGCNK 282 Caenorhabditis elegans
Q9TZ00       251 IIPLYLLIT------LDEVELKFfi-iVCIIFDLFITPLLIQVSYLGCNK 293 Caenorhabditis elegans
Q9N5W5       244 LISLVQSLTLVLinkETEEIDMVlltfTMMIMDTAYAPLIIQTCYLGCNK 293 Caenorhabditis elegans
Q5WRL4       224 CIYAIHIFQSPLhelNEVIL-------KYQYLDICHVSFFPQISYLLCNK 266 Caenorhabditis elegans
Q93869       240 IIFGICIFFKLSseyHTMKA-------ISTTRDMYVSIFVIQLSYILCNK 282 Caenorhabditis elegans
Q86D22       238 FIYIPIFLFNGDw--FA----------VNEALDGYISIFLIQASYLVCNH 275 Caenorhabditis elegans
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