1H6F,4A04,1XBR,5T1J


Conserved Protein Domain Family
T-box

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pfam00907: T-box 
T-box
The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.
Statistics
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PSSM-Id: 459990
Aligned: 105 rows
Threshold Bit Score: 165.81
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1H6F_A          7 VHLEAKELWDQFHKRGTEMVITKS-GRRMFPPFKVRCSGLDKKAKYILLMDIIAAD-DCRYKFHNSRWMVAGK-AD-PEm 82 
Q9U2C9         12 VSLNKPEIWEKFYPK-TEMIVTRKrGRVIFPHLDYNVKGLDPDSLYSIYIHLERVD-GIKYKFDAGEWKEAGK-GD-PI- 86  Caenorhabditis...
Q9XVD5         12 VSLSTPEIWEEFYPK-TEMIVTRNrGRVIFPHLDYIIKGLDPGSLYSIYIHLERVD-GIKYKFDAGEWKEFAK-GD-PI- 86  Caenorhabditis...
13_pfamImport   1 LALHEPKTWQEFHPN-TEMIVTRKrGRVIFPHLDYLISGLEPTSLYSVFVHLERVD-NVKYKFDQGEWQYATK-GD-PI- 75 
EFP03381        9 VSLSNQDQWEKFHPM-TEMIVTRKaGRRLFPHLNYILKGLDPNELYGVFIHFERVD-KNRYQFLRNKWNVFGK-SD-EV- 83 
XP_003103799    9 VSLSNQDQWEKFHPM-TEMVVTRKaGRRLFPHLKYILKGLDPDAKYGLFLHFERMD-NIKYKFSVNKWKEFAK-GD-EI- 83 
XP_003095069   14 VSLSNQEQWEKFYPH-TEMVVTRKsGRLLFPHLKYILKGLDEDTEYSVFLHFERID-NWKYKFLSRGWDKWTE-GD-KK- 88 
14_pfamImport   1 VALQDRQLWKEFDTLCNEMIITKI-GRNLFPIIEYAFKGLQEHVEYQVGVTMQLTNcQ-KLKFTAGKWDPLDVpEEvF-- 76 
Q1T6W8          5 VALMEKSLWREFDSQCNEMIITKI-GRNLFPILEFAFKGLCEHLNYKIGVTMEPISyQ-KLKFTAGRWESLDIqEEmV-- 80  Caenorhabditis...
XP_003103922  146 VALLDKALWREFDAQCNEMIITKI-GRNLFPILEVSFKGLNEHLHYRIGVTMEPTViQ-KLKFTGGRWEKLDVmEDmV-- 221
1H6F_A         83 PK-RMYIHPDSPAT----------GEQWMSKVVTFHKLKLTNNISDK--H--GFTILNSMHKYQPRFHIvR---ANDILK 144
Q9U2C9         87 LPiQYKEHPRGKRT----------GTEWMSEPVSFAHLKITNDPENKd-Q--KLILAQSLHKYIPVLHIkQldpYK-GTF 152 Caenorhabditis...
Q9XVD5         87 LPiQYKEHPRGKRT----------GAEWMSEPVSFAHIKITNNPEIKd-Q--KVILVQSMHKHIPVVTVkQvrhYK-TGY 152 Caenorhabditis...
13_pfamImport  76 REvQYYEHPHGARS----------GEHWMSDPVSFASLKITNDPMCEn-P--KLIIVQSMHKYQPVVTIkK---IG---- 135
EFP03381       84 RHiKVEQHLDGWRA----------GSYWMTKPVSFEHVKITNNPDLKk-S--NTFVLQSMHKFKPVIGVqK---MG---- 143
XP_003103799   84 RPiERKLHKDGWRL----------GGHWMENPVSFEYFKITNDPEMDk-D--DAVLVQSMHKHIPVLSIqR---EN---- 143
XP_003095069   89 LPiDMKQHKDEWKC----------GRDWMKDPVSFDYIKITNNTEAKk-E--NEILLQSMHRYLPVISIqK---KG---- 148
14_pfamImport  77 ------------QPneifmakpksGRELMQRGLKLDKLKLTNTKEAVvkNdqM-IRVQSMRQYIPVLHIy------EVVA 137
Q1T6W8         81 ------------QPnevf--lmksGRELLQRGLKLEKLKLTNSKDALqkSdqM-IRVQSMRQYMPVLNIy-----EISPV 140 Caenorhabditis...
XP_003103922  222 ------------QSnevf--yvksGRELLQRGLKLEKLKLTNSKDALqkSdqM-IRVQSMRQYVPVLNIy-----EATPT 281
1H6F_A        145 LPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRD 187
Q9U2C9        153 QMDFHGVEFRLEATQFIVVTAYQNEELTKLKVHHNKFASGFRS 195 Caenorhabditis elegans
Q9XVD5        153 QEDFSGEQFRLEATEFMVVTAYQNEILKNLKVHHNKFASGFRS 195 Caenorhabditis elegans
13_pfamImport 136 --NFRGEEFRLKVTEFMVVTAYQSNHVNDLKKKHNKFASGFRA 176
EFP03381      144 --DSKIEGFRLDVTEFMAVTAYQNNDIKELKIQMNRFASGFKE 184
XP_003103799  144 --AEK-EEFRFGVTEFMAVTAYQNKNIIQLKIEMNRFASGFKE 183
XP_003095069  149 --GMEKEEFRLGITEFMAVTTYQNNSIASLKVELNQHASGFRQ 189
14_pfamImport 138 TGVRLVGKYEFAETKFVAVTAYQSERVKQLKVQRNKFAQGFRE 180
Q1T6W8        141 GAHNQIGKFQFPETKFIAVTAYQSELVKQLKVQKNKFAQGFRE 183 Caenorhabditis elegans
XP_003103922  282 GATVHVGRFPFVEAKFIAVTAYQSEQVKCLKVQKNKFAQGFRE 324
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