Conserved Protein Domain Family
7TM_GPCR_Srj

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pfam10319: 7TM_GPCR_Srj 
Serpentine type 7TM GPCR chemoreceptor Srj
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.
Statistics
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PSSM-Id: 370974
Aligned: 35 rows
Threshold Bit Score: 336.907
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O16981         1 MLDDIIYYFTPRVFCALTFLVNPFFVYLIFTEKAAKFGNYRFILLFFATYNLTFSVFNIVFPMDIHTYRYCFYLMIKDGW 80  Caenorhabditis ...
XP_002635674   2 IYVNWYHYHIPKLFGIFSFLINPIFIYLVLKKSKSQMGKYRYLLIFFACFDVAYSVAELLTPIAVINTGYGFVTFITDGP 81 
O17124         2 IYINWYQKNMPLIFGISSYIVNPLFIYLVLTKSSKQMGKYRFLLIGFAVFDVFYSIAEMLTPIAVINTGYGFVTFITDGP 81  Caenorhabditis ...
P91506         2 IYMNWYHQNVPKILGALSFLVNPIFIYLVVTKTKTQVGSYKNLLIMFSVFDILYSISEILTPLGVQGNKHGFVVFISDGL 81  Caenorhabditis ...
Q9UAW7         2 IYISWYHQNLPRIFGIFSFIINPIFIYLAMTKSRSQMGKYKYLLIIFAIFDILYSISEILTPIGITGNKHGFVVFLTEGP 81  Caenorhabditis ...
P91507         2 IYISWYHQNFPRIFGVFSYIINPIFIYLALTKSKTQMGNYRFLLVAFAVFDLFYSTNEFLTPLAVTGNSHGFVVFLTEGP 81  Caenorhabditis ...
P90760         2 IYIGFTHFWTPIIFGTLSYFSNSIFIYVVLLNTRANIGAYKYMLVCFGLFDITYSTVDMLVAMGSHSEGNTFCVFVTHGP 81  Caenorhabditis ...
XP_002636682   2 IYVGFLHHWAPIIFGILSYICNSIFVYIVLKKTRSSFGAYKYMLMSFGIFDIMYSTVDMVVAMGSHSEGNTFCLFVSHGP 81 
P91504         1 MYIHWSHHYLPKLFGILSFVCNPIFICLIATEKKASIGKYRYLLIGFAIFDMAYSTVELIVPVAIHGTGAAFVIYLADGP 80  Caenorhabditis ...
O17809         1 MYIHWTHYYLPKVFGVLSFILNPFFIWLILNENITALGSYRYLLVTFASFDIIYTLVELAVPMSIFGTGAAFAVFVSGGP 80  Caenorhabditis ...
O16981        81 FVESTELNFHLLVARCSIVFASNAILLTHFVYRYLVIHESNFTKKYF-GWYIAASFLIFGLFFGVWYAICYHLARVNIEI 159 Caenorhabditis ...
XP_002635674  82 FFDNYMNGQHGVSSRCCFISLSYAILIIHFVYRYLVLFSPDYVNRVFePLGIFVILAYFTFHGVSWTWICEFCLAPNDEI 161
O17124        82 FSENAN---YAVSSRCTFISMSYALLIIHFVYRYLILFYPHQVDKMLqPFGILAMIVLTAGHGASWTWLCEGCLSPNEEI 158 Caenorhabditis ...
P91506        82 FFEYPELGQHAMSNRCGFISISYALLIIHFVYRYMALFYPHKLHLFFrPIGILFLTLLMLFHAGSWTMICQNCLAADDEV 161 Caenorhabditis ...
Q9UAW7        82 FFEHPEIGQHVMSNRCGFISLSYALLIIHFVYRYMALFHADKLPIFFqPLGIIISIIFLLMHAASWSVICQQCLAGNEEV 161 Caenorhabditis ...
P91507        82 FFEHPELGAHAISNRCGFISLSYALLIIHFVYRYIALFHPELHRNFFhPIGVLIYALFLLIHGASWSVICQQCLGGTDEI 161 Caenorhabditis ...
P90760        82 FSNYLDLGFFAPCVRCMFFSLSYGVLELHFIYRYVALCYPKRLSHFGdPKWILIMISAVFGQGLLWFFSVYFLMWPDSET 161 Caenorhabditis ...
XP_002636682  82 FAEDPEMGFAALCVRCMFFSLSYGVLEVHFIYRYVALCRPQWIPAFAdPKWITAMALGVMGQGIVWFCSVYFCMWSDDEM 161
P91504        81 FFGTGKLGQLAVSIRCGCISLSYGILVIHFIYRYLVLFNTRIIDRLLrPSGLFGLFVFFVFHGIAWSSVCEMCLYGDQEV 160 Caenorhabditis ...
O17809        81 FYGTGKLGQFALSVRCGFISLSYGILVIHFVYRYSV--FTQISHQKLgFWALLGLFIFLISHGIVWSSVCELLLYGDQKV 158 Caenorhabditis ...
O16981       160 RQYIREDFRETYGTDSKNYNMIGVLFQEGSEETTFRSWIVIILWTSLSVASLISFIILATLIMCKLk--KTAMHVSQATS 237 Caenorhabditis ...
XP_002635674 162 RDMIRPAFEEVYHVNSDIVPCLTGQYMNASTYVMAKSWIGISSLTLFSTYCMTVYVVLGYKILTKI---SKNCAMSKNTL 238
O17124       159 RDMIRPAFLEIHHVNSDNISLLTGQYRNASDFVVYKSLFGIMSLTLFSSYCMCVYIILGYKIMKKM---NENTNMSSISA 235 Caenorhabditis ...
P91506       162 RKIVRSSFIDQYGEESNGVPMLAALYWGVRPGIQFRSWLGIILLTIISWYSMAVYFVLGYKIIHKIrcmTINRTLSATSL 241 Caenorhabditis ...
Q9UAW7       162 REIISIDFLENFGANSKSLPMLAAIYYDASDYIRFRSWLGIFLLTAFSFYAMSVYIILGFKIMRKItlmQSTNKLSKNSI 241 Caenorhabditis ...
P91507       162 RELIRDEFMAEYHADTRDVPMLAALYWNASDAIRFRSWLGIVLLTVISFYAMTIYFVLGYKIMRKIrsmQANSSMSKNSI 241 Caenorhabditis ...
P90760       162 RSYLVIPFRRDYNADVHKIPLLASTYWGASTQLILRTSTAIIIVTLISCFTICFCIWIGWTIQSKL----KVADMSKTTK 237 Caenorhabditis ...
XP_002636682 162 RSYLEVPFRRDYNADVYKVPILGSTYWGASTGLIARTSAGIVIISIISCWTIYFCIWIGWTIHSKL----SVVEMSKTTK 237
P91504       161 FDYIYDAFQKDYHVDSHDLSMLMALFFDASPEIKRRSWIGILLLTGISIYAISLYVILGWKIMKKL---ADNPGVSATTQ 237 Caenorhabditis ...
O17809       159 ADYIYKQFMKDYHVDSHGLFFLMGLFYDGSSEIVRRSWGGILILTGVSFYAAPLYFILAWKIVRKLa--NDNPGVSVITQ 236 Caenorhabditis ...
O16981       238 KFQFELLRALIVQTIVPICISYSPCLLCWYSPMFGVQLPREVNYFEVSALGIFSFVDPLAIIFCLPPLRKRI 309 Caenorhabditis elegans
XP_002635674 239 AMHRQLFKALVIQTCIPIFASFLPTVIAWYAPIFQINLTWWNNYICIIALAAFPFIDPIAVICFIPSYKNTI 310
O17124       236 TLNRQLFKALVAQTCIPMFASFLPTVIAWYAPMFLINVTWWNNYICNVALAAFPLIDPAVVIYFIPNYKNTL 307 Caenorhabditis elegans
P91506       242 RLQRQLFVTLVVQTCIPIVASFLPTVISWYAPIFGIDIGWWNTNVSTIALAAFPCIDPLAVIILVPNYRNTL 313 Caenorhabditis elegans
Q9UAW7       242 RLQKQLFQTLIIQTCIPIIGSFLPTVISWYAPIFGVNMEWWNMNVATVAMAAFPFIDPLAVIYLIPSYRNAI 313 Caenorhabditis elegans
P91507       242 RLQKKLFLTLIIQTCIPIFASFLPTVLSWYAPIFGIDLSWWNTNVATVALSAFPFIDPLAVIYLVPSYRNAI 313 Caenorhabditis elegans
P90760       238 RMHRNLLKALAIQTFIPFAISYIPCVVAWSVPIIHVDTKSLNNYTSIIAVAAFPFIDPLAIMVFLPEYRKLF 309 Caenorhabditis elegans
XP_002636682 238 KMHRNLLKALAIQTFIPFAISYIPCVFAWTVPLIHVDSKSLNNYTAVIAVAAFPFIDPLAIILLLPDYRNAF 309
P91504       238 KLHRQLFKALAVQTFIPICISFSPCMMAWYGPVIGLDLGMWNNYLGVIALSAFPVLDPLAIIFLLPNYRNKL 309 Caenorhabditis elegans
O17809       237 KLNRHLFKALVVQTLIPICICFFPCMVAWYGPAFGVNFGNWSRYLGAVAFSAFPDLDPLAIILLLPYYRNKL 308 Caenorhabditis elegans
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