1CI8,3HLG,5GKV,2QMI,4GDN,1EI5,2DNS,4Y7P,4KZ4,1RGY,1XX2,4WZ4,1BSG,4M3K,6W2Z


Conserved Protein Domain Family
Beta-lactamase

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pfam00144: Beta-lactamase 
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Beta-lactamase
This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.
Statistics
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PSSM-Id: 395092
Aligned: 127 rows
Threshold Bit Score: 52.5052
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1CI8_A    22 LDAVFDQALRerrLVGAVAIVARHGEILyrraqgladreagrPMREDTLFRLASVTKPIVALAVLRLVARGELALDAPV- 100 Burkholderia gladioli
KEF02916  50 LRALEREHQA---RIGVFALNLATGASL--------------LHRAHELFPMCSVFKTLAAAAVLRDLDHDGSQLARVIr 112
1BSG_A     7 LAGLERASGA---RLGVYAYDTGSGRTV--------------AYRADELFPMCSVFKTLSSAAVLRDLDRNGEFLSRRIl 69  Streptomyces albus G
P35393    46 LRALEQEHSA---RLGVYARDTATGRTV--------------LHRAEERFPMCSVFKTLAVAAVLRDLDRDGEFLATRLf 108 Streptomyces lavend...
P35392    46 LRALERTHDA---RLGAFAYDTGTGRTV--------------AYRADERFPIASMFKTIAVAAVLRDLDRDGEVLARRVh 108 Streptomyces fradiae
OOR99666  50 LANLEQQYQA---RIGVYVWDTETGHSL--------------SYRADERFAYASTFKALLAGAVLQSLPEKD--LNRTIs 110
4M3K_A     7 FAKLEEQFDA---KLGIFALDTGTNRTV--------------AYRPDERFAFASTIKALTVGVLLQQKSIED--LNQRIt 67  Bacillus licheniformis
P06548    59 FAKLEKEYNA---KLGIYALDTSTNQTV--------------AYHADDRFAFASTSKSLAVGALLRQNSIEA--LDERIt 119 Bacillus cereus
6W2Z_A    22 FVQLEKKFDA---RLGVYAIDIGSNKTI--------------AYRPNERFAYASTYKVLAAAAVLKKNSIEK--LNEVIh 82  Bacillus subtilis s...
P00809    55 FSQLEKKFDA---RLGVYAIDTGTNQTI--------------SYRPNERFAFASTYKALAAGVLLQQNSIDS--LNEVIt 115 Bacillus cereus
1CI8_A   101 -----------------TRWLpefrprladgsePlVTIHHLLTHTSGLgywllegagsvydrlgisdgidlrdfdldenl 163 Burkholderia gladioli
KEF02916 113 yteadvt--ksghapvtKDHId----------tG-MTIRDLCDATIRY-------------------------------- 147
1BSG_A    70 ytqddveqadgapetgkPQNLa----------nG-MTVEELCEVSITA-------------------------------- 106 Streptomyces albus G
P35393   109 yteqevkdsgfgpvtglPENLa----------aG-MTVERLCAAAICQ-------------------------------- 145 Streptomyces lavend...
P35392   109 ytadyvkrsgyspvtglPENVa----------nG-MTVAELCEATLTR-------------------------------- 145 Streptomyces fradiae
OOR99666 111 ysqkdl----vsyspetQKYVg----------kG-MTIAQLCEAAVRF-------------------------------- 143
4M3K_A    68 ytrddl----vnynpitEKHVd----------tG-MTLKELADASLRY-------------------------------- 100 Bacillus licheniformis
P06548   120 ytrkdl----snynpitEKHVd----------tG-MTLKELADASVRY-------------------------------- 152 Bacillus cereus
6W2Z_A    83 yskddl----vtyspitEKHLd----------tG-MSLKEISEAAIRY-------------------------------- 115 Bacillus subtilis s...
P00809   116 ytkedl----vdyspvtEKHVd----------tG-MKLGEIAEAAVRS-------------------------------- 148 Bacillus cereus
1CI8_A   164 rrlasaplsfapgsgwqYSLALD--VLGAvVERATG-QPLAAAVDALVAQPlGMRDCGFVSAEPERFAVPYHDgqpepvr 240 Burkholderia gladioli
KEF02916 148 -----------------SDNCAAnlLLRE-LGGPTAvTRFCRSLGDPVTRL-DRWEPELNSGEPDRRTDTTSP------- 201
1BSG_A   107 -----------------SDNCAAnlMLRE-LGGPAAvTRFVRSLGDRVTRL-DRWEPELNSAEPGRVTDTTSP------- 160 Streptomyces albus G
P35393   146 -----------------SDNAAAnlLLRE-LGGPEAvTRFCRSVGDRTTRL-DRWEPELNSAEPGRLTDTTTP------- 199 Streptomyces lavend...
P35392   146 -----------------SDNTAAnlLLRD-LGGPTAvTRFCRSVGDHVTRL-DRWEPELNSAEPGRVTDTTSP------- 199 Streptomyces fradiae
OOR99666 144 -----------------SDNSATnlLLKE-LGGVEQyQRILRQLGDNVTHT-NRLEPDLNQAKPNDIRDTSTP------- 197
4M3K_A   101 -----------------SDNAAQnlILKQ-IGGPESlKKELRKIGDEVTNP-ERFEPELNEVNPGETQDTSTA------- 154 Bacillus licheniformis
P06548   153 -----------------SDSTAHnlILKK-LGGPSAfEKILREMGDTVTNS-ERFEPELNEVNPGETHDTSTP------- 206 Bacillus cereus
6W2Z_A   116 -----------------SDNTAGniLLQQ-LGGPKGfEKSLKQIGDHVTKA-KRFETDLNSAIPGDIRDTSTA------- 169 Bacillus subtilis s...
P00809   149 -----------------SDNTAGniLFNK-IGGPKGyEKALRHMGDRITMS-NRFETELNEAIPGDIRDTSTA------- 202 Bacillus cereus
1CI8_A   241 mrdgievplpeghgaavrfapsrvfepgaypsggagmYGSADDVLRALeairanpgflpeTLAD--AARRDQAGVGAETR 318 Burkholderia gladioli
KEF02916 202 -------------------------------------YAIARTYQRLVlgna-----lnrPDRAllTDWLLRNTTTLTTF 239
1BSG_A   161 -------------------------------------RAITRTYGRLVlgda-----lnpRDRRllTSWLLANTTSGDRF 198 Streptomyces albus G
P35393   200 -------------------------------------RAIGATYGELVlgda-----lapRDRErlTGWLLANTTSTERF 237 Streptomyces lavend...
P35392   200 -------------------------------------RAIGRTYGRLIlgdl-----laaHDRErlTRWMLDNRTSDERF 237 Streptomyces fradiae
OOR99666 198 -------------------------------------KQMAMNLNAYLlgnt-----lteSQKTilWNWLDNNATGNPLI 235
4M3K_A   155 -------------------------------------RALVTSLRAFAledpg---klpsEKREllIDWMKRNTTGDALI 194 Bacillus licheniformis
P06548   207 -------------------------------------KAIAKTLQSFTlgtv-----lpsEKREllVDWMKRNTTGDKLI 244 Bacillus cereus
6W2Z_A   170 -------------------------------------KALATDLKAFTldnt-----lttDKRMilTDWMRGNATGDELI 207 Bacillus subtilis s...
P00809   203 -------------------------------------KAIATNLKAFTvgna-----lpaEKRKilTEWMKGNATGDKLI 240 Bacillus cereus
1CI8_A   319 GPGWGFGYLSAVlddpaaagtpqhagtlqwggVYGHswfvDRAL---------GLSVLLLTNTAYEgMSGPLTIALRDAV 389 Burkholderia gladioli
KEF02916 240 RTGLPKGWTVADksg--------------ggdTYGT----RNEAaiawtpdgaPVLLTALTHKPSL-PTAPGDTPLIIKL 300
1BSG_A   199 RAGLPDDWTLGDktg---------------agRYGT----NNDAgvtwppgraPIVLTVLTAKTE--QDAARDDGLVADA 257 Streptomyces albus G
P35393   238 RKGLPADWTLGDktg---------------ggAYGT----NNDAgvtwpphrpPVVMVVLTTHDR--PDAVADNPLVAKT 296 Streptomyces lavend...
P35392   238 RKGLPADWLLADktg---------------ggDYGT----NNDAgvawppgrpPVVLAVQTTRFT--PDAEADNVLVAEA 296 Streptomyces fradiae
OOR99666 236 RAATPTSWKVYDksg---------------agKYGV----RNDIavvripnrkPIVMAIMSTQFT--EEAKFNNKLVEDA 294
4M3K_A   195 RAGVPDGWEVADktg---------------aaSYGT----RNDIaiiwppkgdPVVLAVLSSRDK--KDAKYDDKLIAEA 253 Bacillus licheniformis
P06548   245 RAGVPKGWEVADktg---------------agSYGT----RNDIaiiwppnkkPIVLSILSNHDK--EDAEYDDTLIADA 303 Bacillus cereus
6W2Z_A   208 RAGAPIGWEVGDksg---------------agSYGT----RNDIaivwppnraPIVVAILSNRFT--KDANYDNALIAEA 266 Bacillus subtilis s...
P00809   241 RAGIPTDWVVGDksg---------------agSYGT----RNDIavvwppnsaPIIVLI-SSKDE--KEAIYNDQLIAEA 298 Bacillus cereus
1CI8_A   390 YA 391 Burkholderia gladioli
KEF02916 301 AT 302
1BSG_A   258 AR 259 Streptomyces albus G
P35393   297 AA 298 Streptomyces lavendulae
P35392   297 AR 298 Streptomyces fradiae
OOR99666 295 AK 296
4M3K_A   254 TK 255 Bacillus licheniformis
P06548   304 TK 305 Bacillus cereus
6W2Z_A   267 AK 268 Bacillus subtilis subsp. subtilis str. 168
P00809   299 TK 300 Bacillus cereus
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