Conserved Protein Domain Family
DUF621

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pfam04789: DUF621 
Protein of unknown function (DUF621)
Family of uncharacterized proteins. Some are annotated as having possible G-protein-coupled receptor-like activity.
Statistics
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PSSM-Id: 398453
Aligned: 15 rows
Threshold Bit Score: 340.456
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003112400   32 ETVPDVQKTWIYYIVISCFVLTAIASTLLTGGFLVMSVVLWNHLKT--------MKFFWFLTQLTFSSFMISILNLIFNV 103 
CAO82042       37 AEIPPEDKNFLYYFIIATFTASTIISTLLTGAFLVASVILWKRFKH--------MKFFWFLCMLTLSIFIISILNLLINV 108 
EFP11074       63 AEIPPEDKEGVYYFIVTLFVFATFASTLMTGAFLAMSIALWGHFKQawkkfhlnMKFFWFLTQLTIAVFIMSSLNFLINV 142 
CAP29162       32 AEVPPQQKTSLYYLVITLFVISVIACTLLTGAFLVLLILLWGQFKS--------IKYYWFLSQLTVSVFFLSSLNLVINV 103 
Q6BES6         30 dTLPESEKNWMFYFVILLFVLSTVTATLLTASFLIMAVFLWNHLKP--------MKFFWFLLQLTISAFILSTLNLVFNV 101  Caenorhabditi...
EGT32880      309 GEIPEDQKQGTYYFVVSFFVFSTIVSSLLTSVFLVLAITVWNHFKR--------IRFFWFLIHLLISVFIISASNLLMHV 380 
O44177         14 lDISDSEKNWLYYSVVSFFVVSTIGATILTMSFLVLSILLWRHFKS--------MRFFWFLTQLTTSAFVISAANLFINI 85   Caenorhabditi...
NP_507594      13 LEISGSDKNWIYYCVVSFFIISTLGATVLSAGFLVLSVYFWTHFRS--------IRFFWFLTQLTTSTFIISASNLFINI 84   Caenorhabditi...
EGT32880        1 ---lplsQKWTLLSIVGLFVTTTVVSTLLTAAFLVLSILLWSHFKH--------IRFFWFLVQLILSVFIISGSNLLIHV 69  
NP_506279      29 AEVPPEEKGPGYYLVTTLFVVSIIASTLLTGSFLVLLLLLWKHFKS--------LKYFWFLMQLTLSVFILSTLNLVINV 100  Caenorhabditi...
XP_003112400  104 PATLLSVATKQLVPSELYFIVLYLMDFFLHSILFSNLVIAFQRLFVFFPSKKMEF--LFGTPLLYLWMILIYTLPIFILF 181 
CAO82042      109 PATLFSLLTKDFVKSEAFLLISYIIDICHYTILFCNLVIAVQRCFVFFFRNLADS--VFDTPFMYAWMISVYLLSLLVVY 186 
EFP11074      143 PATLFSLITKEFVKSDAFFLMSNVIDFCHNAVLFSNLLIAIHR------------------PLVYIWMILVWILSGAVVL 204 
CAP29162      104 PATLFSLLTPDFVTSDIYIILSYTADYMHYSILISNLVIAIQRFSVFLFRNYSST--LFDSHFVYIWLVIVWLAPGAIIF 181 
Q6BES6        102 PATLFSVATEQFVQTNLYLIMSYVIDFCLHSILFSNFVMAIQRFAVFFHLHISDI--IFESPYIYIWLVMIYVLPSLTLI 179  Caenorhabditi...
EGT32880      381 PASL-GLIEEHHFETEIFHFISYLIDFCHYSILFSNVVIAINRAVIFFQNSSSYSniVFEPPFIYIWLSVVWLLSFGVES 459 
O44177         86 PAAL-SLFSKEVTQSRMFYFVSYLIDFCHYSILFSNLVIAVQRAFVFFLRNLTDR--FFESKVIYIWISSIYIFAFGVEY 162  Caenorhabditi...
NP_507594      85 PAAL-SLFPKEVTQSELFYFVSYLIDFCHYSIIFSNLVIAVQRGFVFFLRNLTEQ--LFESKIIYIWLASIYIFSFGVEF 161  Caenorhabditi...
EGT32880       70 PATL-GLLSPSTLNSEIFIFVTYLIDFSHYSIIFSNTVIAINRGVLFFKKSSVAAk-TFESPFIFFWFLLIWLMPLGIDY 147 
NP_506279     101 PATLFSLITKDFVASDVYTTLSYTIDYFHYAILISNMVIAIQRFCVFFFRQLTAK--IFDSFIIYEWLCLVWILPAIILL 178  Caenorhabditi...
XP_003112400  182 SLFQNDCSYKY-NAIEQ--------KFKLYCPKVVsgieSLTKEPPEGIQILENVIQVGIPVVILVLYIALVIRVIKLKR 252 
CAO82042      187 AMMYNNCRYRY-SLNVL--------HYELYCQTSA----VVNLPPPKAISIMEIVIQFAIPCIIFGIYIALTIKIMIMKQ 253 
EFP11074      205 SMMSKNCRYEYdMAVLE--------HYVLKCRTESg----IAISPSSVIQMIEIAMQFVIPIFILAVYIALVAKICTIKQ 272 
CAP29162      182 FMAYNNCRYVFlKAKKD--------NFVLKCETAGs---VVDLPQPEWIRFMELALQFGIPVLIFCMYVAVVFKICSMKK 250 
Q6BES6        180 FLGQDNCMYRF-DNREQ--------KFTLTCFNTVgt-nKVKIEIPRIIQIIEDTIQIVIPIIILILYIALVIKIIKMKK 249  Caenorhabditi...
EGT32880      460 VLISYDCSYKY-NHLRT--------RLQFICQKPAes-slIFLGNPRIIQVIDAIIQIALPVLILLIYFSIILRMILMKK 529 
O44177        163 ALMSSNCQYRF-GELAR--------KYQLICETTNyanvVITMTTPTEVQLMETMLQIFLPLSILIIYIAITVKIIYMKG 233  Caenorhabditi...
NP_507594     162 TLMISNCQYRF-GETASgkysgnsgKYQLICETVGygniIISMATPAGVQLMETVLQIGIPIFILCIYFAIITKIVSMKG 240  Caenorhabditi...
EGT32880      148 VLMSAGCRIQL-NLKMK--------NFRMKCEKYSnf-fLIHTETPLGIQIIDVLLQIGLPAFIFLIYSSIVVSIAFARN 217 
NP_506279     179 ILVFNNCKYNF-KKAPS--------NFVLNCQPWGs---IVDLPPPRWIQILELVVQFGIPFFILFLYIAVIFKIFAMKK 246  Caenorhabditi...
XP_003112400  253 SKRNTNEIIILKQAFFIFVMFQIYNIVTLFGKTLYINVATAFYLKRAIHTA--------------EIFAGAATPCIVFST 318 
CAO82042      254 SSLKSSEITILKQAFFVFFVFQVSSVVFLLCQTVKFGVATAFLIKRVINTM--------------EILAGAATPCFFFFT 319 
EFP11074      273 GAQNNYELTILKQAVFIFALFQISSIVFLLCQTLKFKVATAFLIKRVINTVnqcmsnyksfeiqtEIFAGAATPCFFFFT 352 
CAP29162      251 SALNKQETRVLVQAIIIFLLFQASSTVFLFCQTLSFNAATAFIIKKSINTL--------------EIFAGAATPCFSFFA 316 
Q6BES6        250 TSRNKTEIIILKQAFFIFLMFQIYNIIVLYGKTLKMTTVTAFYLKRAIHTA--------------EIFAGATTPCFVFFT 315  Caenorhabditi...
EGT32880      530 VSLVNTEKTLLKHSIFAFVIFQSPNCILLISQSFKMSNVSAFLIKRFVNTM--------------EIFGGAITPTFFFFT 595 
O44177        234 STLSKNETLILKQAIFVFLIFQASSCVFLFAQSVQITNVGAFLVKRFVNTM--------------EILAGAATPSFFFFT 299  Caenorhabditi...
NP_507594     241 STLSKNETLFLKQAMFVFIIFQASSCVFLFAQSVQITNVGAFLVKRFVNTM--------------EILAGAATPSFFFLT 306  Caenorhabditi...
EGT32880      218 LSLKDHEKTILKQAIFTFVVFQAPSLVFMGANFFYIEELEAFLIKRFVNTM--------------EIFGGIATPSFFFFT 283 
NP_506279     247 STLNKNEIRVLVQAIVIFVFFQASSSVFLICQTIAFNTATAFVIKRIINTL--------------EIFAGAATPCFSFFT 312  Caenorhabditi...
XP_003112400  319 SREIRKVVSSRIGSGS 334 
CAO82042      320 SKEIKKMASVKSSMNN 335 
EFP11074      353 SKDIRKLVTVKVSASS 368 
CAP29162      317 SEKIRKMLSSKVPAIS 332 
Q6BES6        316 SKEIKKLVSNKITAGS 331  Caenorhabditis elegans
EGT32880      596 SREIRKIFASRVYATN 611 
O44177        300 SKEIRKLVSTRVSAVS 315  Caenorhabditis elegans
NP_507594     307 SKEIRKLISTKVSAVS 322  Caenorhabditis elegans
EGT32880      284 SQEVRKIMTSRVYATN 299 
NP_506279     313 SKEIRKLLSSKIAAVS 328  Caenorhabditis elegans
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