Conserved Protein Domain Family
7TM_GPCR_Srx

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pfam10328: 7TM_GPCR_Srx 
Serpentine type 7TM GPCR chemoreceptor Srx
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.
Statistics
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Structure
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PubMed ReferencesClick to see Conserved Features Help

pfam10328 is a member of the superfamily cl28897.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7JLI4    27 IVNGIFGSVCNLSIVYIFMYVPKEKTSFNLICVFRSLGNTIILLWgFIATFVPITLTGQSQF--WKPYEt-VVIISCNNI 103 Caenorhabditis elegans
EYC42246  66 FVVGVPGLYLNMLSTFSLFGAATP---FEMICACHAAGNAGVLAV-LIFCSAPMIYFGSPWLnvSEFGK--MAGRVTMYA 139
EGT33844  35 ILTSAFGIFVNLFVFRRFVSKN--MTSFYIMCSSKTISNSMILFC-YLIFNGPVSVMRRYYG--PEMMNmlLNQMAAYGV 109
O02072    61 ILLSAFGIFINILVLHRFIAKN--MSSFYLLCSSKTVSNSIILFC-YLVYNGPVSVLQVYYG--PEMFNilFNQIAAYGV 135 Caenorhabditis elegans
O02071    35 IIASAFGIFINILVLHRFIAKN--MSSFYLMCSSKTVSNSIILFC-YLIFNGPVSVGRSYYG--PEFMNmlLNQMAAYGI 109 Caenorhabditis elegans
PIC48383  17 ILVSLIGLFFNVSAFYQYLSQE--KTNFYIMCISKTISNSLHLLV-YLLYNGPSALLYTQMG--PEWLNryLNQAIAYGL 91 
O44877    17 IIASIIGLFFNLSAFRKYLSLE--KTSFHVMCISKTVSNSLHILV-YLLYNGPSALLYAQLG--PELLNryLNQAIAYGL 91  Caenorhabditis elegans
EGT49776  17 ILVSIIGLFFNLSAFYQYLSLE--KTSFHIMCISKTVSNSLHLLV-YLVYNGPSALFYTQIG--PEIVNryLNQAIAYGL 91 
O44879    16 IFVSFVGFLINFFMLFHFLTLE--KTSFHLLCVSKTLSNSLILLV-YLVYTGPVHLLYTQIG--SIELNilLHHFAMYGL 90  Caenorhabditis elegans
EFO88857  16 ILTASIGLCINVLMFHHFWKLE--KTSFYMLCISKTVSNCMTLLI-YLLYVGPVNAFYNPIG--TLELNayLNQALGYGL 90 
Q7JLI4   104 YMVIQYSGVFIAVNRFCALFLPIVYKKLFHIKTTFILTMIIIALKLIDnLNylITFLPIECFTFYS-SNNLAWVPNIQSH 182 Caenorhabditis elegans
EYC42246 140 WFLIHYTQVLLAINRFMAINCYMIYNKVFSSANTKKILAVLGIYLLW--YF--FVGFFDGCHFIFL-STTWQWAFEQTQC 214
EGT33844 110 YVQGPMTQVCISFNRFLIIYFATLAKRKNGRKATFMALSICWLISLF--VT--VAGIPGNCTNIYN-YDILTWDNL-DPC 183
O02072   136 YIQGPMTQVCISFNRFMVIYFVSLAKRKSGRVLTITALSICWTISLI--VT--VIGIPDKCTNIYL-YEYLTWDYS-DSC 209 Caenorhabditis elegans
O02071   110 YVQGPMTQVCISFNRFMVIYFVSLAKRKSGRLATITALCTCWTISFI--VT--IAGIPKNCTNIFN-YEILTWDNL-DPC 183 Caenorhabditis elegans
PIC48383  92 YCQGPLTQALITINRFLIVYFQPIIVPWYSKWITFASLAFCWIIAFYF-ST--LIGFPETCLIKFS-HQKLTW-IH-EEC 165
O44877    92 YCQGPLTQALITINRFLIVYFAPIVIPWYSKWITFGSLSACWIIAAYF-ST--LIGFPESCLIRFS-HQSLTW-MH-DEC 165 Caenorhabditis elegans
EGT49776  92 YCQGPLTQALITVNRFLIVYFTPVVIPWYSKWITMGSLTACWVIAAYF-ST--LVGFPESCLLRFS-HQYLTW-IH-DDC 165
O44879    91 MLQGPITQLIITINRVLVLWFLPLQIPKSSRYLTTVIIILTWIFVGWQ-ST--LFGLPEDCKSPFAfFEHTFYTT--ASC 165 Caenorhabditis elegans
EFO88857  91 ILQGPITQCLITINRLLVVWIFELYVPQYSGTITIFAISLSWVFTIWV-ST--LFGLPDNCRVPFA-FPHVGYTQ--TDC 164
Q7JLI4   183 CHIDDNVPNp--FNSTAFVLIVIIFINVANFIRIRMFYKSTE-TEVAEkKRKMKKNTVLFGQTLFQDCIMLFDMLFTFKL 259 Caenorhabditis elegans
EYC42246 215 GLILFIYVD---FYFTIGLLITSLAFDFCTAISIY---RFVK-ITASTdRHFGHTDVMFFIQSCMSNFIFIADLSLFLVG 287
EGT33844 184 VDTLADLV----MYWIGVLAVISNTFNVVVAIKLIVSATKPH-MDSVAsKRRRRTSRRLFLQSCFQDWIYLLDTINSMFI 258
O02072   210 VFLLADLV----LYWIICLAIVSNTFNVMVAVKLIVSSKKSH-LDTMAsKRRKKTSRNLFLQSCFQDWIYLIDTVNGMYI 284 Caenorhabditis elegans
O02071   184 VDILADAV----MYWIGFLAIISNTFNVVVAVKLIVSASKPH-MDSTAsKRRKRTSRNLFLQSCFQDWVYLIDTINSMYI 258 Caenorhabditis elegans
PIC48383 166 PYIIHFILQsdfLFLVLPLGLFSNFMNIFIAIKLFLLSKSQs-LSNETsRQRRKTTIRLFIQNCFEDWIYVLDTVNSLFI 244
O44877   166 PYFIHYILQsdfLFLVLPLAVFSNVMNVFIAIKLFLSSKTQn-LSTEScRHRQKTLIRLFIQNCFEDWVYVLDTVNSLFF 244 Caenorhabditis elegans
EGT49776 166 PFFIHYILQndfLYLILPLGIFSNSMNFFIAFKLFSQSKSQs-LSNETgRQRRNSTVRLFVQNCFEDWIYVLDTVNSVFF 244
O44879   166 STTMFWIKN----YVVFSLAAVTNFLNLMMAVKLVVVSRTQKsISSVAyQRRRKRSIKFFFQSCIQDWISAVDAANNAAS 241 Caenorhabditis elegans
EFO88857 165 NNQVTWYM----LYGILGLAASTNFMNILIAAKLFCRSRSQKrLSSEAhRSRRKLSIRFYFQSCSQDWISVLDFANNIAS 240
Q7JLI4   260 AG-IS----K--E-RYWTFFSGTLVWELVHSLDGFVMVMFN 292 Caenorhabditis elegans
EYC42246 288 PTiYQallgEapD-TFGIFLINTLSMEISHFLDGLIMVVFN 327
EGT33844 259 YT-WL----D--K-IIWQFFFTIFSNLFVHVMDGCIMLFFN 291
O02072   285 YN-WF----N--SvTW-QFGCTILSNLMVHVSDGCIMLFFN 317 Caenorhabditis elegans
O02071   259 YS-WF----S--D-ILWQFFFTIFSNLMVHVTDGCIMLFFN 291 Caenorhabditis elegans
PIC48383 245 RD-SV----N--D-GFVIFLVTLGSNLITQVADGFVMFMSN 277
O44877   245 RN-TA----N--H-PFLIFIVTLGSNLFTQLADGLVMYVSN 277 Caenorhabditis elegans
EGT49776 245 RN-TV----N--D-GFVIFLVTLGSNLVTQVADGSVMFISN 277
O44879   242 TK-YC----E--N-QSCIMLISMSVDVVVFGVDGFVLYWFN 274 Caenorhabditis elegans
EFO88857 241 FT-YC----L--S-QVCVTSITMGFDVFVYGADGFVMYMFN 273
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