3WDN,3A8I


Conserved Protein Domain Family
GCV_H

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pfam01597: GCV_H 
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Glycine cleavage H-protein
This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
Statistics
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PSSM-Id: 396258
Aligned: 13 rows
Threshold Bit Score: 151.331
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3WDN_A   3 RKFTEKHE----WVTTENG-VGTVGISNFAQEALGDVVYCSLPEVGTKLNKQEEFGALESVKAASELYSPLSGEVTEINK 77  cattle
P39726  45 VRYTSQHE----WIAVHQDkTAFVGITKYATDALGDATYVELPEVGTEIAQGESLGSIESVKSASEIYQPADGTVEEINT 120 Saccharomyces cerevis...
O67080  23 LYYDIENQv---WVRVNEDgTVTLGLTDVGQTRAGRLLHIRVKPVGTKVKKGKPVATLESGKWAGPVPALVEGEIVEVNP 99  Aquifex aeolicus VF5
O62122  24 RLYTKKHE----WIVVNQS-VGTVGITDFATEQLGDVVFIELPEAGVEIEKGDSTGAVESVKAASDIYAPVSGKILEKNT 98  Caenorhabditis elegans
Q20634  22 RLYTKKHE----WVLVENG-VGTVGITDFATEQLGDVVFIELPDEGTEISKGDSTGAVESVKAASDIYAPISGTVTQKNV 96  Caenorhabditis elegans
P73560   9 LYYLDSHE----YVRFDGE-TATIGLSAFAVDELGDIVFVELPEEGDKVEFEQSMGAVESVKAASDLYSPVTGTVIEKNS 83  Synechocystis sp. PCC...
O32174   7 LRYSGEHE----WVKVEGE-KARIGITHFAQSELGDIVFVELPEVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNE 81  Bacillus subtilis sub...
O67192  15 RYYTKEHE----WVRVKNg-FAEVGITDYAQKQLGDIVYVDLPEKGKEVDAGDTLANIESVKNVAPVYAPVTGTVVEVNE 89  Aquifex aeolicus VF5
O67573  17 LYYDIENQv---WFKVNEDgTVTVGVTDIGQARAGKIINIRIKPPGKYVKKGKPVASLESGKWAGPVPADIEGEVVERNE 93  Aquifex aeolicus VF5
O66720  14 LYYINPDKnafiWAKE-EDgVFTIGLTSVAAAMAGRLVAYTPKKVGKAVKKDKSVATIESGKWVGPVPSPFDGEIVEVNE 92  Aquifex aeolicus VF5
O67151   6 LYRVEPYRmlfqWVKDEGNgIYSVGMASILAALAYPLYSIKIKPVGTKLEYDEALAIIEAGKRVATFPTPLSGIVVDVNE 85  Aquifex aeolicus VF5
3A8I_F   8 LKYSKEHE----WLRKEADgTYTVGITEHAQELLGDMVFVDLPEVGATVSAGDDCAVAESVXAASDIYAPVSGEIVAVND 83  Escherichia coli K-12
P25855  41 LKYANSHE----WVKHEGS-VATIGITAHAQDHLGEVVFVELPEDNTSVSKEKSFGAVESVKATSEILSPISGEIIEVNK 115 thale cress
3WDN_A  78 ALAENPGLVNKSCY-EDGWLIKMTF---SNPSELDE-LMSEEAYEKYIKSI 123 cattle
P39726 121 NLEENPGVVNEDPM-GDGWLVKMKLgegVNVEQVEG-LMSLEQYEKTLVHD 169 Saccharomyces cerevisiae S288C
O67080 100 KVVEDPNYINIDPY-GDAWIVKIKPtseETLKRDLSeLAHGEKAHEEMKKH 149 Aquifex aeolicus VF5
O62122  99 KLEDEPGIINKSPL-EKGWLYRLEI---TSNEQLNE-LLTEEQYNKFKSEE 144 Caenorhabditis elegans
Q20634  97 KLEEEAGLINKSPF-EKGWLYKLKV---KSADELEK-LLNEEQYAKFKKDE 142 Caenorhabditis elegans
P73560  84 ALEDQPELLNQDPYgEEGWLIKVRL---DDVEDAKEgLMAAGDYRATLETG 131 Synechocystis sp. PCC 6803 substr. Kazusa
O32174  82 DLDDSPEFVNESPY-EKAWMIVVEP---SDASEIEK-LMTAEQYEEMTQED 127 Bacillus subtilis subsp. subtilis str. 168
O67192  90 DLKDEPGIINDDPY-EAGWIAVIEM---KD-PTEVEdLMTAQDYAEYLKEI 135 Aquifex aeolicus VF5
O67573  94 KLFDKPDLINEDPY-GEGWIAKLKP---ANLERDLQdLVTGEEAVQKLKEY 140 Aquifex aeolicus VF5
O66720  93 ALKGNPALVNDDPY-GQGWIAKVKP---ANPEEAKSvLVDANKAAELLQPI 139 Aquifex aeolicus VF5
O67151  86 EVIKNPELINKKPY--SSWIAKLKA---TNLEEVKN-LQSAKEIVKTVKDF 130 Aquifex aeolicus VF5
3A8I_F  84 ALSDSPELVNSEPY-AGGWIFKIKA---SDESELES-LLDATAYEALLEDe 129 Escherichia coli K-12
P25855 116 KLTESPGLINSSPY-EDGWMIKVKP---SSPAELES-LMGPKEYTKFCEEE 161 thale cress
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