Conserved Protein Domain Family
Ariadne

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pfam19422: Ariadne 
Ariadne domain
This entry represents the Ariadne domain found in the Ariadne subfamily E3 ubiquitin ligase proteins. The C-terminal Ariadne domain adopts an elongated four-helix bundle consisting of an antiparallel arrangement of seven-to-ten-turn long helices. The Ariadne domain is straddled on one side by the IBR domain, and on the other by the RING2 domain. Notably, the Ariadne domain embraces the surface of RING2 containing the catalytic Cys357. The ariadne Domain Masks the HHARI Catalytic Cys357 and Inhibits Intrinsic E3 Activity.
Statistics
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PSSM-Id: 466073
Aligned: 23 rows
Threshold Bit Score: 447.175
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
TEY41442     339 KEDGKKKAERAKRDLYRYMHYHNRYKAHTDSFKQESRMRETVKEKVLHLEVRDLKLREFSWVTNGLYRLFRSRRSLSYSY 418
POO03193     326 KEEKVQKAEHAKRDLLRYIHYHNRYKAHTDSFELETNLKTTIQEKISRLEERESTNKDFSWVTDGLYRLFRSRRILSYSY 405
XP_002313070 337 KEDREKQTERAKRDLYRYMHYHNRFKAHTDSFKLESKLKESILDKVSVAEERELRLKDFSWVTNGLNRLFRSRRVLSYSY 416
Q949V6       333 QDDKEKQMERAKRDLNRYTHYHHRYKAHTDSSKLEDKLRDTIHEKVSKSEKRELKLKDFSWVTNGLDRLFRSRRVLSYSY 412 thale cress
XP_002886198 333 QEDKEKQMERAKRDLERYMHYHNRYKAHTDSSKLEAELSYSIRKKVSFSEKRELQLKDFSWATNGLHRLFRSRRVISYSY 412
RWR95662     327 IEDTAKKAERAKRDLYRYMHYHNRYKAHTDSLKLESKLKETIQDKISIAESNESGIKDYSWLTNGLYRLFRSRRVLSYSY 406
PKA66490     342 KEDRVKRIESARRELDRYMHYHNRYKAHTDSLKQESNLKETILGKIAISENKDSRIKDYSWVMNGLNRLFRSRRVLSYSY 421
XP_010243296 270 KDDNAKRVEHAKHDLHRYMHYYNRYKVHTDSFKLETMLKEIIQDKISISESKQPTLKDFSWVTNGLNRLFRCRRVLSYSY 349
XP_015629775 347 TEDQSKKTEQARRNLYRYMHYHNRYKAHTDSLKQEAKLKGDIQGKISISENKDSKIKDYSWVINGLNRLFRSRRVLSYSY 426 Japanese rice
XP_018683650 344 KDDQAKRTERARRDLYRYMHYHNRYKAHTDSLKQESNLKETIQGKISISENKESKIKDYTWVINGLNRLFRSRRVLSYSY 423 wild Malaysian ...
TEY41442     419 PFAFYMFGDDLFKDEMTEKQREIKQNLFEDQQQQLESNVEKLSKFLEEPFAEYPEEQVMQIRMHVINLCVVIDSLCKKMY 498
POO03193     406 PFAFYMFGDERFNNQMTKEEREIKKNLFEDQQQQFEANVEKLSSILEEPFDQFSEDKVVKLRMDIINLSTVTDKLCGKLY 485
XP_002313070 417 PFAFYMFGEEFFKDEMTDEEREIKKNLFEDQQQQLESNVEKLSMFLEEPFQQFSQDKVMDIRMRVINLSVTIDTLCQKMY 496
Q949V6       413 AFAYYMFGEEMFKDEMTPEEREIKKNLFEDQQQQLESNVEKLSQFLEEPFDEFSNDKVMAIRIQIINLSVAVDTLCKKMY 492 thale cress
XP_002886198 413 PFAFYMFGDELFKDEMSTEEREIKQNLFEDQQQQLEANVEKLSKFLEEPFDQFADDKVMQIRIQVINLSVAVDTLCKKMY 492
RWR95662     407 PFAFYMFGDDLFKDEMTPGERELKQHLFEDQQQQLEANVEKLSKFIEAPFDVISGDTINEIRMRVINLSMITDNLCKKMY 486
PKA66490     422 PFAFYMFGDELFKDEMTPQETDLKQNLFEDQQQQLESNVEKLSMLLESDFQEFSDEEVMENMKHVINLSSVIDRLCKQMY 501
XP_010243296 350 PFAYYMFGDILFKDEMSKEEREIKQHLFENQQQQLEANVEKLSEFIEEPFDEYLEGKIMEIRMQVIDLSVITDSLCKKMY 429
XP_015629775 427 PFAFYMFGDEIFKDEMTSDERELKQNLFEDQQQQLEFNVERLSGFLERDFQNFSDDEVMDTMKHVINLSNVVDRLCKQMY 506 Japanese rice
XP_018683650 424 PFAFYMFGDELFKDEMTPQERDMKQNLFEDQQQQLEANVEKLSMFLEKDFQHFSDDEVMDIMRHVINLSNVVDRLCKQMY 503 wild Malaysian ...
TEY41442     499 DCIENELLGSLEFSIHSIAPYHSNGIEKAEELIVGWNAQA--SGN--NKCqk-eaDRSNGkvvlfsfsceelcwvgvmpf 573
POO03193     486 ECIENELLGTLQWSTRNIAPYKSKGVDKASELIVCTDMKL--YHT--EKD-----SSKDG-------------------- 536
XP_002313070 497 ECIESDLLGSLHLGTHHIAPYKSKGIERASELSSCWNTKL--GST--DEYl----PSGGT-------------------- 548
Q949V6       493 ECIENDLLGSLQLGIHNISPYRSKGIEQAAQFYASWNSKD--ADK----Fq----PLDSG-------------------- 542 thale cress
XP_002886198 493 ECIENDLLGSLQLGIHNITPYRSNGIERASDFYSSQNSKE---A----VGei-cqSSDCGts------------------ 546
RWR95662     487 ECIENDLLGSLQRTIHNIAPYKSKGVERASELSVCSDSDQ--STR---SMn----PCKANce------------------ 539
PKA66490     502 LCIENELLYPLQRATHNIAPYKSKGPERASE-------HS--SRF--TKAtnediDVQHG-------------------- 550
XP_010243296 430 ECIENDLLGSPQFAIHNIAPYRSKGVERATELSGCWNTKA--DYA--DNHt----PSDSG-------------------- 481
XP_015629775 507 QCIENDLLYPL-RTPHNIAPYKSKGLDRASELNVCWDSSE--QGLqpIKYsqdehKSQPG-------------------- 563 Japanese rice
XP_018683650 504 QCIENDLLYPLQRATHNIAPYKSKGLERASELSVCWDSDQslTSTk-TSHdd--nSAQLGs------------------- 561 wild Malaysian ...
TEY41442     574 sllgynICGigcmfhhlyicLKri---tRRPAgvd--qaSts---gTSdeslkSRKRPRKESSad----kLFDLN---LP 638
POO03193     537 ------MCI-----------IT------HMPI-------T------CVl----NLLYVRIYFL-------FFFPNivfVE 569
XP_002313070 549 ------SEH-------------------DRPSgsg--ssDds---gCS-----YRKRAKKEgg------gFFDLN---LP 584
Q949V6       543 ------TSG------------Vt-----SRPEqas-gsrSsed-tiCSs----SQKRPKKEGSflnnkvtLLDLN---LP 590 thale cress
XP_002886198 547 ----gwTSRl------------------DQALgsg--nsEdt---sCS-----SNKRARIDGSyrnsqttLLDLN---MP 591
RWR95662     540 ----srANGa----------SDsgmpylDDRFyes-sslDes---gCS-----TRKRAKKEALgd----vLLHLN---LP 589
PKA66490     551 ------SAVna-------sgSPs----pAKRLsqfqpssSsdgkhgCS-----STKRAKNEGSld---tpLFDLN---MP 602
XP_010243296 482 ------INRtg-------grIEl-----GRPFpgt-pnlDei---gCS------RKRARKQALgd----dLFDLN---LP 526
XP_015629775 564 ------LSG-----------SSi----fGKRQlg---ssSnn---nGR-----PHKRERNDAHgg---aaLFDLN---VP 605 Japanese rice
XP_018683650 562 -----aHNGi---------gVAv-----PSKHass--ssDes---gCS-----SRKRARTEAQgg---apLFDLN---MP 606 wild Malaysian ...
TEY41442     639 A-----DAH 642
POO03193     570 EkleinNTN 578
XP_002313070 585 Aei--vDRN 591
Q949V6       591 Adf--vDQN 597 thale cress
XP_002886198 592 Aea--iERK 598
RWR95662     590 Aev--vDRS 596
PKA66490     603 Aev--vDKS 609
XP_010243296 527 Aev--iDKS 533
XP_015629775 606 Aev--aDKI 612 Japanese rice
XP_018683650 607 Aev--iDKS 613 wild Malaysian banana
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