1WAW_A 2 KLVCYF-TNWA----QYRQgeaRFLPKDLDPSL---CTHLIYAFAGMT----NHQLST-------TE--WNDET------ 54 human Q9GV28 24 KVLCYY-DSRSyv--reSqa--rMLPLDLDPALs-fCTHLLYGYAVIQpd-tYKLVSL-------NE--NLDIdr----- 82 domestic silkworm Q9W3V1 68 RLVCYY-ASDGth---------nLSLLDVPGDL---CTHINIGPATLDn--aTIVLPDt-------------lR------ 113 fruit fly Q18143 373 TRLCYL-DPEEve--------etFPIDNLKSDY---CSHIVVPYFALDls-dKMIEEDk--------------------- 418 Caenorhabditis el... Q90184 128 ELWCGY-DNSAmy--rtG-----FPINPSMPKQyskCTGIIYNKVILTt-----nEK--------NR--DPRypkmqsyv 184 Salmonid herpesvi... Q9Z9M9 282 AVTGYW-QNFNngatVQK-------ISDVPSAY----DIIAVAFADATtt-pGAVTFNldsaglgGY--TVD-------- 338 Streptomyces coel... Q9FAC9 35 LLVGYW-HNFDn-----Gtg--iIKLKDVSPKW----DVINVSFGETGgd-rSTVEFSpv------------yG------ 83 Bacillus cereus Q9RHU3 58 AVTGYW-QNFNngatVQK-------LSDVPADY----DIIAVAFADATtt-pGAVAFNldsaglgGY--TVD-------- 114 Streptomyces ther... Q9S5K1 278 ALVGYLhASFAn-----Gsg--yTRMADVPDSW----DVIDLAFGEPTsvtsG--DIRfercp-----vaecpN------ 333 Streptomyces coel... CBA35206 30 KLVCFY-DAQS----FVREgpaQMSLAELEPALq-fCNFLVYGYAGIDav-tYKIKSL-------DPslTNDRQ------ 89 fruit fly
1WAW_A 55 -------LYQE--FNGLKKMn--PKLKTLLAIGGW--------NF---GtQKFTDMVAtANNRQTFVnSaIRFLRKYs-F 111 human Q9GV28 83 ------tHDNYraITSLKAKy--PGLTVLLSVGGD--------ADteeP-EKYNLLLEsQQARTAFInSgVLLAEQYg-F 144 domestic silkworm Q9W3V1 114 -------QVLQndTRSFRAa--hPQVHLLLWIGG---------ADs---gRSFALMVAnhAMRKLFLrSlREILRTYpsL 172 fruit fly Q18143 419 ------aEDLVkkIDDWRSKiveVAPRLILSVGSK--------QA---S-TIWQFLLGnDFHRKELAeGlVKAINSTn-A 479 Caenorhabditis el... Q90184 185 hwkdtwsHRYK--NLLLRn----PNLLMLV--GG---------N----P-SEWALALTsQKTIEPFTrScIDVMRLHk-F 241 Salmonid herpesvi... Q9Z9M9 339 ----------Q--FKADVRAkqaAGKKVIISVGG----------------EKGTVSVNssASATNFAnSvYSVMREYg-F 389 Streptomyces coel... Q9FAC9 84 -------TDAE--FKSDISYlksKGKKVVLSIGG----------------QNGVVLLPdnASKQRFInSiQSLIDKYg-F 137 Bacillus cereus Q9RHU3 115 ----------Q--FKADIAAkqaAGKKVIISVGG----------------QNGTISVNdDASAQAFAdSvYGLMQEYg-F 165 Streptomyces ther... Q9S5K1 334 -------VESDaeFKAAIKAkqaAGKKVLISIGGQ--------NG-----Q--VQLTSt-AARDKFVsSvSAIIDEYg-L 389 Streptomyces coel... CBA35206 90 -------HYRH--ITALRKKy--PHVRFLLSVGGDrdvnsegvAD---S-DKYLRLLEqSEHRKSFQaSvLAELNNNg-F 153 fruit fly
1WAW_A 112 DGLDLDWEYPGSQG------SpavDKE---R-FTTLVQ-DLANaF----QQe---AQTsgKERLLLSAAVPAGQTYV--D 171 human Q9GV28 145 DGIDLAWQFPRVKp-----kK---IRS---T-WGSLWH-GIKKtF----GTtpvdEKEs-EHREGFTALVRELKQAL--I 204 domestic silkworm Q9W3V1 173 DGIDLDWEFPSAYD------R---ERM---H-LSQLLY-EIRTeW----RRe-------kRTNDILSLAVAAPEGIA--F 225 fruit fly Q18143 480 DGLEISWTSQ---------------PM-----VSDFDKkNLKSfI----NDiv-aADT----AKMVEIVVATSQQSA--- 527 Caenorhabditis el... Q90184 242 KGIILDWEPSGNt------aR---DFE---------IE-NFKK-L----GEsfidKMGp-SSEEMLAAAVSTKYPWN--- 293 Salmonid herpesvi... Q9Z9M9 390 DGVDIDLENG--------------LNP------TYMTQ-ALRAlS----AKa--------GPDMILTMAPQTIDMQS--T 434 Streptomyces coel... Q9FAC9 138 DGIDIDLES-GIYLngndtnF---KNPttpQ-IVNLIS-AIRTiS----DHy--------GPDFLLSMAPETAYVQGgyS 199 Bacillus cereus Q9RHU3 166 DGVDIDLENGi-------------------N-ATYMTK-ALRSlS----DKa--------GPSLVITMAPQTIDMQT--P 210 Streptomyces ther... Q9S5K1 390 DGLDIDFEGHSLSLnaddtdF---KNPktpV-IVNLVS-AVKTlK----AKy--------GDGFVLTMAPETFFVQLgyQ 452 Streptomyces coel... CBA35206 154 DGIDLAWQFPKNRP------K---LQQ---GvFKRVWG-SLRGwFssssVDe---KSE--EHREQFATLLEELQSDL--R 213 fruit fly
1WAW_A 172 AG-----------------YEv------------------DKIAQNLDFVNLMAYDFHG-SWE--K---------VTGHN 204 human Q9GV28 205 HK-----------------PKmqlgvtvlpnvnstiyhdvPAIINLVDYVNVGAYDYYT-PTR--Nn-------kEADYT 257 domestic silkworm Q9W3V1 226 YAyd-----------------------------------iREINLYADYVNLMSYDFHFyRED--Tp--------FTGLN 260 fruit fly Q18143 528 YS-----------------DFyd----------------yEHLNKTASLIVLHSHRLHS---D--Sl-------pFTGHP 562 Caenorhabditis el... Q90184 294 MRyd-----------------------------------iAHTHKFFNKIFMKTFGMAS-ISE--VggkkcdtawEIGST 335 Salmonid herpesvi... Q9Z9M9 435 QG-----------------GYf------------------QTALNVKDILTVVNMQYYN--SG--T---------MLGCD 466 Streptomyces coel... Q9FAC9 200 AY------------------Gsiwg------------aylPIIYGVKDKLTYIHVQHYN-AGS--G----------IGMD 236 Bacillus cereus Q9RHU3 211 SA-----------------GYf------------------QTALNIKDILTVVNTQYYN--SG--T---------MLGCD 242 Streptomyces ther... Q9S5K1 453 YY-----------------GTgkwggqd-----pragaylPVIHALRDDLTLLHVQDYN--SG--S---------IMGLD 497 Streptomyces coel... CBA35206 214 RGgqlltvsmlphvsaelfIDv------------------PKVLSNVDFVNLGTYDFQT-PERdpK---------VADLP 265 fruit fly
1WAW_A 205 SPLYKRqeeSGAA---ASLNVDAAVQQWLQKG--TPASKLILGMPTYGRSFTLASSSdtr-vgAP---AtG-SGTP---G 271 human Q9GV28 258 APIYTP---Qnr---npLQNADAAVTYWLtSG--APSQKIVLSXRLRSYLETGXDSEiagvppIH---TdG-PGEA---G 322 domestic silkworm Q9W3V1 261 APLYAR---SQERslmATFNINYTVQWWLkSG--LEPQRLVVGLPTYGHSFTLVNPLnhr-igAP---AsG-YGK----- 325 fruit fly Q18143 563 SPLRAT---SSMTn--QKMSWESLLSHWVeKR--VLPSKLVLSLSASTLSMQSLADVr----sSA---AtPfGQSAfvsM 628 Caenorhabditis el... Q90184 336 WGLDNL---KCQTk-qQYHYLKYAVEFYQ-KA--VPVSKLVFGLVLYANVFEKVQGRf----kDP---EcGy------iI 395 Salmonid herpesvi... Q9Z9M9 467 GKVYAQ---GTVD----FLTALACIQLe--GG--LAPSQVGLGLPASTR-------------------AaG--------- 507 Streptomyces coel... Q9FAC9 237 GNNYNQ---G---------TADYEVAM---------ADMLLHGFPVGGN-TNNIFPAlr--sdQV---MiG-LPAA---P 285 Bacillus cereus Q9RHU3 243 GQVYAQ---GSVD----FLTALACIQLe--NG--LAPSQVGLG--------------------VP---AsP-SAAG---- 283 Streptomyces ther... Q9S5K1 498 NQYHSM---GG-------------ADFHIAMT-----DMLLTGFPVAG-DANNVFPPlr--pdQV---AiGmPAST---- 546 Streptomyces coel... CBA35206 266 TPLYAM---YDRD---PSHNVQYQVQYWMNQTteISVHKLHVGVTSYGRAWNMTRNSgit-gyPPipaAnG-AAPP---G 334 fruit fly
1WAW_A 272 PFTKEGGMLAYYEVCSwk-----------gATKQRIQD-QKVPYIFRd------N--QWVGFDDVESFKTKVSYLKQKGL 331 human Q9GV28 323 PYVKTEGLLSYPEVCGklinpnqqkgmrphLRKVTDPSkRFGTYAFRlpddngeGg-IWVSYEDPDTAGQKAAYVKSKNL 401 domestic silkworm Q9W3V1 326 --CGQLGFTTLTETCEcvtk-------ffkPNLSYDAE-SCSPYLSAl--------qEWISYENQTSIACKANYVKSLNL 387 fruit fly Q18143 629 LRSKKGDIHSQQEICEslk--------sgtGVTHWVDG-AEVPYLRR-------Yd-QMVAYENTRSAHIKAVWASMEGV 691 Caenorhabditis el... Q90184 396 PITCAPGKVGPAVLHDdpe--------hykCKVNSLQQcCQSVFEMDrr-------hYYASWDNVETHKLKIQEVFDN-- 458 Salmonid herpesvi... Q9Z9M9 508 -----GGYVSPSVVNAald---------clTKAT-----NCGSFKPS-------Kt-----------------YPDLR-- 542 Streptomyces coel... Q9FAC9 286 AAAPSGGYISPTEMKKal-----------nYIIK------GVPFGGK-------Yk-----------ISNQSGYPAFR-- 328 Bacillus cereus Q9RHU3 284 -----SGYVSPSVVNDald---------clTQGT-----NCGSFKPS-------Kt-----------------YPDLR-- 318 Streptomyces ther... Q9S5K1 547 -QAG-NGHVSPAEVTKaln---------clTKKT-----DCGSYATH-------Gt-----------------WPDLR-- 584 Streptomyces coel... CBA35206 335 RQTVTPGLLSWPEICDllqqqpq-drevphLRKVGDPTkRFGIYAYRaad-dqgEngLWVGYEDPLTAAIKAGFVHAQGL 412 fruit fly
1WAW_A 332 GGAMVWALDLD 342 human Q9GV28 402 GGVAIVDLSLD 412 domestic silkworm Q9W3V1 388 GGVMVFSLNTD 398 fruit fly Q18143 692 GGLALHNMHQD 702 Caenorhabditis elegans Q90184 459 -----YGISTS 464 Salmonid herpesvirus 2 Q9Z9M9 543 -GAMTWSTNWD 552 Streptomyces coelicolor Q9FAC9 329 -GLMSWSINWD 338 Bacillus cereus Q9RHU3 319 -GAMTWSTNWD 328 Streptomyces thermoviolaceus Q9S5K1 585 -GLMTWSINWD 594 Streptomyces coelicolor CBA35206 413 GGVAFHDLSMD 423 fruit fly
Jiyao W et al.(2023). "The conserved domain database in 2023.",