Conserved Protein Domain Family
Eapp_C

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pfam10238: Eapp_C 
E2F-associated phosphoprotein
This entry represents the conserved C-terminal portion of an E2F binding protein. E2F transcription factors play an essential role in cell proliferation and apoptosis and their activity is frequently deregulated in human cancers. E2F activity is regulated by a variety of mechanisms, frequently mediated by proteins binding to individual members or a subgroup of the family. EAPP interacts with a subset of E2F factors and influences E2F-dependent promoter activity. EAPP is present throughout the cell cycle but disappears during mitosis.
Statistics
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PSSM-Id: 463015
Aligned: 50 rows
Threshold Bit Score: 120.063
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EED91344     102 YCSNMDDEDEAWVYKHMRSgqeelvyvrqrqqqkevaegktgqpnvkgesgsgqqdgktgndgqsntkqetpvsqnqqiq 181
XP_002178576  46 YDDTADQNDERYVRKNLRSgitefvssfddnet-------------------------------------adnrqshpas 88 
EFA78388      57 YNEDEDDENEAWVEKNLKK------------------------------------------------------------- 75 
EGG19992      70 YDDKEDDLNQQWVDKNLKS------------------------------------------------------------- 88 
XP_002998034 219 YDEQLDDADEQWVQTNLCGt------------------------------------------------------------ 238
ESS32388     280 YDSSADEEDEKWVAKHLRV------------------------------------------------------------- 298
Q4N739        36 YGSDLDDLDDDFVNDNYRQ------------------------------------------------------------- 54  Theileria parva
Q8I657       104 YDEKIDNYDEEYVNKKYRF------------------------------------------------------------- 122 Plasmodium falc...
XP_002257858 105 YDDRIDIFEEEYVNKKYRF------------------------------------------------------------- 123
POM78961     214 YDEQLDDADEDWVQTNLRGtq----------------------------------------------------------- 234 Phytophthora pa...
EED91344     182 qallLKPRSSDAILSCPRCFTTVCMDCQEHERYAGQYRAMFVMNIGVDWNKRMVYDeamgglklasaGAGGRITAASGSA 261
XP_002178576  89 rlkdLKPRNSDAVLSCPCCFNIVCLDCQQHERFADQFRAMFVLNVVVQWESKLFYD-----------EQHKCLRSLDDIP 157
EFA78388      76 -----SGSKSDAYLSCPCCFTLVCVDCQRHDTFKNQYRAMFVKNCKIDFSNRLLYQnddgddtldekQQEDDEEEVDDEQ 150
EGG19992      89 ------TNKTDAYLSCPACFTLLCVDCQRHDLYKNQYRAMFVKNCTIDYQSKLVYKeekk----khpKKSKGKGNGNGKE 158
XP_002998034 239 ---rATKPETDATLCCPCCFVTVCMVCERHATYTNQYRATAAINCRVKRDEILAYTsgegsqvpaslPFHKRQTLVAS-- 313
ESS32388     299 -----GDRTTDAILCCPGCFTPVCYQCQRHEKFLFQYRAVSACNVVVDSAFVSPSNrvpaerpdaraSSSPRPASRDGAC 373
Q4N739        55 -----GDKSTDAVLCCAMCFTPVCYQCKT---VGNTFSSKLALNAYVEDNYSDSANrsdsrdvlgkgDSTKRKLRGST-- 124 Theileria parva
Q8I657       123 -----GTKSCDSSLCCCGCFIPVCYQSQRHEYYVNQYRALYAINIRIDEDTIIDEHeinskryeendKDHGNNENKQNNE 197 Plasmodium falc...
XP_002257858 124 -----CTKSCDSSLCCCGCFIPVCYQSQRHETYVNQYRSLYAVNVRIEDKKIIHEHeina---------------tdnTK 183
POM78961     235 ----aVKPETDATLCCPCCFVTVCMVCERHATYTNQYRSTAAINCRVKKDEILTYTsnegsrvpaslPFHKRQNLAG-GD 309 Phytophthora pa...
EED91344     262 MQADGEDGAmdeddapd---------------------------------------------------------tiphdh 284
XP_002178576 158 TSAMIEHQIfpms------------------------------------------------------------------p 171
EFA78388     151 EEDDDNYNEdvntpkedntan-------------------------------------------------kkqvdtgttk 181
EGG19992     159 PTSIATTDDhdnd-----------------------------------------------------------------dq 173
XP_002998034 314 NKATSSGQQlar-------------------------------------------------------------------l 326
ESS32388     374 EAGGDGGETaeegkgdkadkadrerreiegerekgqelsfvnhlremvqdrswerggnkrgstqktdrkrgeeeeifceg 453
Q4N739           --------------------------------------------------------------------------------     Theileria parva
Q8I657       198 SDK----------------------------------------------------------------------------- 200 Plasmodium falc...
XP_002257858 184 GGKRSHSHGdprippplekpenqaelp-------------------------------------hpefeetpegekeged 226
POM78961     310 SKSTTTGQQiar-------------------------------------------------------------------l 322 Phytophthora pa...
EED91344     285 ekDELYYSVHCGYCQHELAVLDMGdEIYYFFGCIAS 320
XP_002178576 172 dkSCCYFSVCCAICQTQVAVIDMSdEVYHFFGCLAS 207
EFA78388     182 rnKEYYHAVHCQICSTQLAVYDQD-EIYHFFNVFPS 216
EGG19992     174 qiEEDYYSVECSNCTTKVAVYDKD-EIYHFFNVFPS 208
XP_002998034 327 lqEDEFYPVACSDCGTMVGVFDRD-QHYHFFNALPS 361
ESS32388     454 leGQSAHAVKCATCSATVALLDEA-ETFHFFHVLPg 488
Q4N739       125 --SDSERIVKCIECNNVIAVLDFS-NNYNFKNVIAS 157 Theileria parva
Q8I657       201 --SLKYHAVFCINCNNHIAYFEIQeRIFHFFDVLPD 234 Plasmodium falciparum 3D7
XP_002257858 227 ekSQTYHAVFCENCNNHVAYLEIKkNIFHFFDVLPD 262
POM78961     323 lqEDEFYPVACSDCSTMVGVFDRD-QQYHFFNALPS 357 Phytophthora palmivora var. palmivora
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