Conserved Protein Domain Family
PTB_CG12581
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cd01217: PTB_CG12581 
CG12581 Phosphotyrosine-binding (PTB) domain
The function of CG12581 and its related proteins are unknown to date. Members here contain a single N-terminal PTB domain. PTB domains have a common PH-like fold and are found in various eukaryotic signaling molecules. This domain was initially shown to binds peptides with a NPXY motif with differing requirements for phosphorylation of the tyrosine, although more recent studies have found that some types of PTB domains can bind to peptides lack tyrosine residues altogether. In contrast to SH2 domains, which recognize phosphotyrosine and adjacent carboxy-terminal residues, PTB-domain binding specificity is conferred by residues amino-terminal to the phosphotyrosine. PTB domains are classified into three groups: phosphotyrosine-dependent Shc-like, phosphotyrosine-dependent IRS-like, and phosphotyrosine-independent Dab-like PTB domains. This cd is part of the Dab-like subgroup.
Links
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Statistics
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PSSM-Id: 241252
Aligned: 8 rows
Threshold Bit Score: 304.393
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putativeputative
Feature 1:putative phosphoinositide binding site [chemical binding site]
Evidence:
  • Comment:based on the phosphoinositide binding site of Dab1
  • Comment:this is in a similar region as the phosphoinositide binding site found in PH domains.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #                                                                     
AAF52174       3 DSTPICRCRVLYLGSAVPRQSKDGLQGIQEPLRSLYPSEgavgAKGIDSWLSVWSNGILLENVDEnlkqITRFFPIESLH 82  fruit fly
XP_002400580   2 STTPICRCRVLYLGSAVPHITKDGLQGIQEPLRELYPEQgplsARGIDSWLSVWSNGLLLENVDEsrrqHVRFFPIETLH 81  black-legged tick
EFX80565      47 GPTPICRCRVLYLGSAVPQVTKDGLQGIQEPLRELYPEGgamgAKGIDSWLSVWSNGLLLENVDEnhqrVTRFFPIDSLH 126 common water flea
NP_871690      1 MPLPLCRCRVLYIGSSVPTITKDGLQGIQQPLKERYPIQespdTRGIDSWLSVWSNGVLLEYIEGekktETVFFPIITLH 80  nematode
XP_001946893  11 DSTPICRCRVLYLGSAVPHITKDGLQGIQEPLKELYPEQgalgARGIDSWLSVWSNGLLLENVDEnhkkITRFFPIESLH 90  pea aphid
EJD76633       2 VAAPFCRCRVLYIGSAVPTITKDGLQGIQQPLRERYPIGgnadTKGIDSWLSVWSNGLLLEYIDGdkrtETAFHPINSLH 81  Loa loa
EFN81864       8 TATPYCRCRVLYLGSSVPHASKEGLLGVQEPLRELYPEQgalgARGIDSWLSVWSNGLLLENVDEhrkkVTRFFPIEALH 87  Harpegnathos sa...
EHJ74807       2 ESTPICRCRVLYLGSAVPQQSKDGLQGIQEPLRELYPEKga-tSGGIDSWLSVWSNGILLENVDEsgsrVSRFFPISSLH 80  monarch butterfly

Feature 1                                                                 #                    # 
AAF52174      83 YCAAVRQVLIPERGNThp-------------------epKFLPLDSPFARmpraQHPPIFAAILRRTTGIKVLECHVFIC 143 fruit fly
XP_002400580  82 YCAAVRYVVVPGSSGTer-------------------veKFLPLDSPFARhagpQQPPLFACILRRTTGIKVLECHAFIC 142 black-legged tick
EFX80565     127 YCAAVRYVLVPSTSPSvagggpggggsaagselgvgrmaRFLPLDSPFARhpniHHPPLFACIMRRTTGIKVLECHVFIC 206 common water flea
NP_871690     81 YCAAVRYVNVEGFKVGgg-------------------geQFMPLDSPFANipnsPHPPIFAAIFRRTTGVKVLECHGFIC 141 nematode
XP_001946893  91 YCAAVRFVLVPEKSNGss-------------------qpRFLPLDSPFARspnpNHPPLFAAILRRTSGIKVLECHTFIC 151 pea aphid
EJD76633      82 YCAAVRYVNVTGYAIEgg-------------------geRFLPLDSPFANgednQHPPIFAAIFRRTTGIKVLECHAFIC 142 Loa loa
EFN81864      88 YCAAVRHVKGGNGDASn---------------------tRFLPLDSPFARtpsaNHPPLFAAVLRRTTGIKVLECHAFIC 146 Harpegnathos sa...
EHJ74807      81 YCAAVRRVSVEGQPRFl---------------------pLDSPFARAPAP----RRPPLFAAVLRRTQGIKVLECHAFIC 135 monarch butterfly

Feature 1                                 
AAF52174     144 KREAAANALVRCCFHAYADNSYARQ 168 fruit fly
XP_002400580 143 KKEPAANALVRCCFHAYADCTYAKQ 167 black-legged tick
EFX80565     207 KRETAANALVRCCFHAYADSTYAHH 231 common water flea
NP_871690    142 TNVKAANALVRCMVHAYTETMHLRM 166 nematode
XP_001946893 152 KREMAANALVRCCFHAYADSSYAKQ 176 pea aphid
EJD76633     143 TNAKAANALVRCCFHAYAESMYIKL 167 Loa loa
EFN81864     147 KRDMAANALVRCCFHAYADSSYAKG 171 Harpegnathos saltator
EHJ74807     136 RREAAANALVRCCFHAYADSSYAKR 160 monarch butterfly

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