4FID,2XTZ


Conserved Protein Domain Family
G-alpha

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pfam00503: G-alpha 
G-protein alpha subunit
G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA.
Statistics
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PSSM-Id: 459835
Aligned: 131 rows
Threshold Bit Score: 119.231
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4FID_A     1 SNAK----PITVXLLGSGESGKSTIAKQLK------ILF--GGG------FPEQe-rAT-HKSSICSNVVTCXRTLIEQS 60  Entamoeba histolytica
EFC49272  94 VKKR-----MNVIMLGTGGSAKTTVLKQFK------LLG-----------GKREdltQSlWQE---GIVVPCFDLLIAIF 148
EFC39834  42 TSTTt--fGANLLFSSRSDDL----FDELE-----------DDDskssqsFQTS---TQ-FLSLLGHNILDQAKKVNDLH 100
EFC36315  32 venviaetDCILALIGTGGCGK---RLEMK--------------------FKEK---------ENSNNYLNRVKLLSGQE 79 
EFC44299  77 NNKR-----MNVLCLGGSDSGKSTFVNTLT------EQY-----------QSNS---KAvSTSEHFECLCRHMSQIAKSY 131
EFC39174  26 steD------EWIILGTADSGTSTFYYMIE------RILrkNRN------YSNRdefNH-DLQIVCSLMIKRLWTILEES 86 
EFC41316  27 TREE------SWIILGTADSGTSTFYYMIE------RILsnNRH------YSNRnefNH-DLQLVCFLMIKNLWTILESE 87 
EFC46774  31 DNHQ------RIVLLGNTSSGKSTICEMIQ--------Y--QKQ------HQADk-sCNtYNLFYKVDSNTISKTIIEQI 87 
EFC44241  61 TINN------NIYCVGCSDGGKTSFHNQLKs-----KFH--MKI------HKNEkirAT----LIIKTCLSSIQDIIFIV 117
EFC47036 153 SALQvyqsHIRFIFLASGESGRKTLSKLIRynlepeVIE--KQA------FDLNqsySTlY--FFFSNTIILLEQFYQML 222
4FID_A    61 AI--L----NHPX--------------KYQPKSKEFTTEDPV----------------TLPFSP-----------ELVGD 93  Entamoeba histolytica
EFC49272 149 NR---------------------------KNFYYPNAEYHHEe---------------SDEVEQ---------------Q 171
EFC39834 101 TT--Q----VQSIpiy---------gnNRKDSVDLSKAPKLVlvgtgssdsidnilgdTTFLSD-----------EICER 154
EFC36315  80 YS--L-------------------------------Fp--------------------ESVWNN-----------ELAKL 95 
EFC44299 132 RQ--D----GHERwpec-------semTNKILFGGEESTEDVss------------pkDDEIQI------------IITD 174
EFC39174  87 ER--NriidMIPKsf-----------gPCLENLNDKSNIDDSq---------------ISEFDYcgllmyiwnipFFRES 138
EFC41316  88 RS--R----IIDLipk--------sfgPCLENLNDKSNIDQSq---------------ISEFDYcellmyiwnipFFRDL 138
EFC46774  88 LF--A----SKDIsi----------eaIIREYTNDCNNFDNS-------------------------------------T 114
EFC44241 118 MSd-----------------------qERNDFIHKIKKSDPQiydflln---ltnitrKWEFTKse-------siQYGQY 164
EFC47036 223 FElkF----PNQCinelppilanvepqIIQEILKDLKEIEDIpmdrefsvdqvnklsnNIPMASnckvvlklitkQVYNN 298
4FID_A    94 VEALW-A--DE--------------------------GIQAT-YE--ESa-KFQ--LP---DCAKY---------L-FE- 124 Entamoeba histolytica
EFC49272 172 VFDLF-D--QKkilniihpnnqklieeiaemwnnepiLRKVC-TEmlLEn-QVEsvPV---EDVNY---------Y---- 230
EFC39834 155 LVDFWmD--EP--------------------------IIQMC-YFfaSIayKFI---E---GYGDYsrnraeksvY-IR- 197
EFC36315  96 IFQMY-Q--DE--------------------------GFQNElFQ--NRq-RIP--FL---ESINY---------FtDKk 129
EFC44299 175 FERIW----ST--------------------------CLKSY-YEknKDakHFT-------ENMNQ---------V-FK- 205
EFC39174 139 FETKW-NaiSP--------------------------NISEN-IKdpNIvmNLL--IL---ENLEE---------L---- 172
EFC41316 139 FETKW-NaiSP--------------------------NISEN-FKdpNIn-YYHvlSLlilENLEE---------L---- 176
EFC46774 115 LFALW-N--DQ--------------------------KFRNI-YQ--SCqdSLN--LF---ENVDI---------F---- 144
EFC44241 165 IRMIW-S--Ky-------------------------kIIQEL-YY--LYk-DSH--HLi--DNIDV---------L-CN- 197
EFC47036 299 LILFF-ErqDVk------------------------lLIRKY-HDllQTq-QHGtiF----DRIEIlksvs--------- 338
4FID_A   125 N---------VKRIAXE--DYVP--------------------------------------------------------- 136 Entamoeba histolytica
EFC49272 231 ----------FSRAVAVhrGDKP--------------------------------------------------------- 243
EFC39834 198 HlnlenlptlIDQLEDVl-SYETegddlqs-------------------------------------------------- 226
EFC36315 130 N---------SSRLLKN--DFQL--------------------------------------------------------- 141
EFC44299 206 ----------NGKLCLQkcKYQL--------------------------------------------------------- 218
EFC39174 173 ----------ISRIKSKs-EFFP--------------------------------------------------------- 184
EFC41316 177 ----------ISRIKSKt-EFFP--------------------------------------------------------- 188
EFC46774 145 ----------VRKLKNHe-SFIP--------------------------------------------------------- 156
EFC44241 198 Emnii--isqLSDHQKN--QFLKntkrrlnqrlnstteivtsnslncnqlennlydqddeedgeeqqqqdaedlyqldnh 273
EFC47036 339 ------hetlCEILEKPsnSFTK--------------------------------------------------------- 355
4FID_A   137 ----------------------------------TE------------------EDLIHN---R--TKTTGIHEYDFVV- 158 Entamoeba histolytica
EFC49272 244 ----------------------------------SD------------------KDLLIS---Q--RKTTGVTHVEFAFn 266
EFC39834 227 ---------------------------kfssaikDD------------------SHIVTElivStyVKTTGIIEIPVKF- 260
EFC36315 142 ----------------------------------NF------------------DDFFFA---S--RKTTGISPFKY--- 161
EFC44299 219 ------------------------------------------------------YNSTNS--------TQRETIRRF--- 233
EFC39174 185 ------------------------------------------------------MALSYT---S----SMGVRDFKY--- 200
EFC41316 189 ------------------------------------------------------LALSYE---I----TKGVREFRY--- 204
EFC46774 157 ------------------------------------------------------DIYIKG---N----SSGITEYDINF- 174
EFC44241 274 innimnskkkskkisifsskfksnfnssqqnnnnTSlnnennnennntshydkySPLIKF---L----TIGKNETKFQF- 345
EFC47036 356 ----------------------------------EE------------------EELILRlffIsrQKLTGCSQFTLQL- 382
4FID_A   159 K-DIPFHLIDVGGQRSERKXWV--S-F-F------SDVDCAIFVTSLAEYDXKLYEDGNTSRLTESIAVFKDIXTNEFL- 226 Entamoeba histolytica
EFC49272 267 NgSTLVNIWDCGGQKNERKKWK--Y-M-FtesqklTGKIFVIYFVALSEYNQLCYEDETTNRTHESLKIFESVANNPEY- 341
EFC39834 261 GdNNLIGLYDTGGQRNERKKWK--N-I-Mnd--nsQTLSGVLFLVPLSEYNQICYEDDSINRTIESLNLFSELVNRNTF- 333
EFC36315 162 VnNHKKAIIDTGGQRTERSKWNrlHnT-Y------SQKLHIGFVISLSEFDELCYEDDITPRFNEGLSNFEEWYGSPLV- 233
EFC44299 234 StSHELNLVTAGGKKMERRRWN--S-LdL------EGTNVLLLFVSLSEFNQQSIEDSKTNRMDESLKTFKELLTKKQL- 303
EFC39174 201 N-NIL--VKNVGGSRSQRKKWI--N-C-F------NGQSLAILLVSLAELDQYTVEDARTLRMQESKMLLGELINSNFL- 266
EFC41316 205 N-NIL--VKNAGGSRGQRKKWL----CcF------NNQSIAIFIISLAELDQYTVEDTQTLRIQESKLLMEELINTRFL- 270
EFC46774 175 D-DKKVTFVTAGGKTSERKKWN--F-ClQ------GNVSVLVYVVSLAEFNQSGYGDEKVNRMDESLKLYKELMTRVSN- 243
EFC44241 346 DsKNLFTILDLGGRGAEKKKWE--F-F-Ln----eTNADFVLFFVSMSEFNQNLIESDNINRLHESLTIYRDIINRALLr 417
EFC47036 383 G-PHKLSFCLVAGQRAERKKYP----R-Ym----eQGFEYVIFCMNLSEYNRNLYENDTITRFRDTIYMAHEYCCQDCK- 451
4FID_A   227 K--GAVKLIFLNKXDLFEEKL--TKV-PLNT--IF--------PEYT---------------G-GDN------AVXG--A 267 Entamoeba histolytica
EFC49272 342 E--NYPLFLIFTKKDIFKQKL--RYT-SLSV--CFedcpedlkANEDttkikrdiinnwtgfLeDRQcvsdeiYEKS--F 412
EFC39834 334 G--SLPFFLIFTKKLVMEEKL------KLYDltYV--------PFKT---------------ElPQD------LKVE--L 374
EFC36315 234 S--EHTLYLIFSKFEVLEEKI--KKGiSFSR--FV--------SEFK---------------GdETS------IESI--V 276
EFC44299 304 K--NSRKVVIFSKPDILQEKL--SVEaRYQRqvC---------DSMK---------------EeLKSmsnlnlERSV--L 353
EFC39174 267 R--RARKIVIFTKPDILIKKLqkGHSiNLGN---Fkm-----rPEFKd-------------iInKHE------LKKV--V 315
EFC41316 271 K--TARKIVIFTKPDILIKKLqkGHSiHLGN--Ykm------rPEFKe-------------iInKHE------LKKV--V 319
EFC46774 244 SgnNTRVVLLFTKPDIMMRKL--RSYiEFGR--LFete---tlTDLS---------------RiVND------YHERdvL 295
EFC44241 418 N--TKDIILIFTKPDIFLHKM--ENNiEFKL------------PNIEglnipkmetirpellKlKDN------IKLE--I 473
EFC47036 452 KygNMSVIPVFTHLDQLMRQI------------YY---------------------------GnVPN------SANV--- 483
4FID_A   268 QYIQ----QLFTGKLQte------eXNIsgadgtaniegavnE----KVYTNPTN-ATDGSNIKRVF-XLA-VDV---I 326 Entamoeba histolytica
EFC49272 413 DFVK----RKFMERIS---------NAD--------------RrkqtEKNIKVVN-AMDADDVRSNLvEELlEQT---M 460
EFC39834 375 KLNEenkkDLLVNILKmknsqidnlTPR--------------EiqliDRFSSDTR-YSPSQLLKIIGgDKT-------I 431
EFC36315 277 EFIV----KKYLEL-----------DVK--------------R----RVVKYYVIsAFKTEQVYQML-NEI-FEI---- 316
EFC44299 354 NSTI----NEYENLFQqy------cKDS--------------K------FDYHVCnTTNEEEVQSCM-QRI-VSN---N 397
EFC39174 316 NSIV----SHYLDF-----------ENEme-----------fN----KIHSFHIVnTTEMEEVNSVL-ERI-LDH---N 359
EFC41316 320 NSIV----SHYLNF-----------ENEie-----------fK----KIHSFHIVnTTELEEVNCVM-ERI-LDH---N 363
EFC46774 296 NTII----SSFLT------------ETN-------------------NIYGK----IPEYHIIQSISeLDI-SQLaklM 334
EFC44241 474 NNLI----NLFENIHLns------fNNI-------------------TFKYHIVN-IINIKECQEFI-EILlRQT---I 518
EFC47036 484 -WIPm--cEEIAKLHNsr-----rsNVM--------------D----FIFSSLIP-VKEVLNKLKYF-AFI-VGY---P 530
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