Conserved Protein Domain Family
NAD_binding_5

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pfam07994: NAD_binding_5 
Myo-inositol-1-phosphate synthase
This is a family of myo-inositol-1-phosphate synthases. Inositol-1-phosphate catalyzes the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated to inositol. Inositol phosphates play an important role in signal transduction.
Statistics
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PSSM-Id: 462335
Aligned: 79 rows
Threshold Bit Score: 358.423
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002259699         91 LGVLLIGIGGNNATTLLGGICANAKKLTYTNkydvkkanylGSVFLSSNVRLGYDAkNlehSYCPIHKLIEVYNPENI-T 169
WP_013445918         12 LGILLPGM-GAVATTLIAGVLASRKGLSKPI----------GSLTQMGTIRLGKRTdK---RNPLIKDFVSLANLDDV-V 76  Paludiba...
WP_014217577         12 LGILLPGL-GAVASTMIAGVIASRKGLAKPI----------GSYTQTGHIELGEGKgD---RYPLIKDFVPLASLEDV-V 76  Niastell...
CDE57758             13 LGVMVVGL-GAVSTTFMTGVLMTRKGLAKPV----------GSMTQYDKIRVGKGAdK---KYLHYKDIVPIADLNDI-E 77 
CCX67001             13 LGILCVGL-GAVSSTFITGVLMIRKGMGKPI----------GSITQMAKIRVGRGDkA---EYKHVSEIVPMPTLDDI-V 77 
CCY16111             13 LGVLCVGL-GAVSTTFIAGSLMCRKGMGLPG----------GSITQMAKIRVGRGDkK---TYKRVGEIVPLADLKDF-E 77 
ASM67271             12 LGVLVVGVGGAVATTMIVGTLASRKGLAKPI----------GSITQLATMRMENNEeK------LIKDVVPLTDLNDI-V 74 
jcvi:cds.PERMA_1920   1 MKLWLFGLYGIVATTAVAGDRAVKKGITDTT----------GLVSSLPVFKD-----------------LERYSPLNFdQ 53 
Q9Z4Y8                3 TGIWLVGARGSVATTTVVGAAALRAGLVPAT----------GCVSALEAFDG-----------------VPLPGFDEL-V 54  Streptom...
jgi:Isova_2168       26 TGLWLVGARGSVATTATLGLAALAHGDAAPT----------GCVTAQPAFDG-----------------VPLPAFADL-V 77 
XP_002259699        170 FGGWDLNNLN--LRDCLVR----NKVFEQDLVEKIKDDMNYV--PLKSVYFKgNFI-AANQQKRVNNILVGKdKLEVLEQ 240
WP_013445918         77 FGGWDLFTDN--AYETANK----AGVLEKSDIEPLKDELIKIk-PMTAVYDH-KYL-VNLTPNNIKEGPt---KMDLAQQ 144 Paludiba...
WP_014217577         77 FGGWDIYEDN--VYEAASN----ARVLDQQLLKAIRPELEAIk-PMKAVFDR-NYV-RNLDGTFIKQSAn---KWEAAQE 144 Niastell...
CDE57758             78 FAAWDVYPAN--AYESAIN----AEVLKEKDIEPVADELKAIk-PMRAAFDH-NYA-KRLDGENYMKGAt---RWEMVEN 145
CCX67001             78 FGAWDILPDN--AFESAMH----AEVLKDRDIYPVKEELEKIv-PMRGIYDQ-DYV-KAIDGTWTKDTTLt--RWQLMEQ 146
CCY16111             78 IGAWDIFTDN--AYQSAMH----AEVLKPCHIEPVRDELERIv-PMKAAFDP-EYV-SRLHGENIKQASt---RWELVEQ 145
ASM67271             75 FGGWDIFPDN--AYEAAMY----AEVLKEKDLNGVKDELEAIk-PMPAAFDH-NWA-KRLNGTHIKKAAt---RWEMVEQ 142
jcvi:cds.PERMA_1920  54 FGGHEIRALDrnLYSELFShweeNQHFDYRILKELEEDLKDIkaKKGTALNCgSGVlEELKPVSTLEDEG-LsLEQIVER 132
Q9Z4Y8               55 FGGHDVVGTG--LVKRAEQla-eAGVVPRGLPGVLTAELDAAdaEI-----------RPAPPGTEEGGDGTPdQASAAGA 120 Streptom...
jgi:Isova_2168       78 VGGHDVSPCP--MVKRAEAlv-eAGMIAPRFLAAARPALESAdaEV-----------RTGYDPREHQGs----QQQAAER 139
XP_002259699        241 VRKQISSFKKTNNLDEVIVLWSGNTEKNIAHIQGVNDTYENILLACKNNHPS-VSPSIVYALASVLENCPFINSSPQNTL 319
WP_013445918        145 LMADIENFKKENNCSRIVVLWCASTEVYSAQTDV-HATVESLEEGLRNNDPN-ISPSMIYAYAAVKLGYPYINGAPNLSC 222 Paludiba...
WP_014217577        145 LIQDIETFKKVNNVNRVVIVWTGSTEKYLEQSAV-HETIASFEAGLKNNDPA-IAPSMVYAYAAVSAGIPFINGAPNLTT 222 Niastell...
CDE57758            146 IRKDIRDFKAAKNLDRIVVLWAASTEVYVPVDEKVHYTLAALEAAMKADDKEhVAPSMCYAYAALKEGAPFIMGAPNTTV 225
CCX67001            147 AREDIRNFKEKNGCSRIVVIWAASTEIYIPRDKNVHDDLTAFEAAMKADDRQhISPSMCYAYAAMSEGAPFIMGAPNTCL 226
CCY16111            146 LRDDIRTFKKAHGCERIVVIWAASTEKYIPYNEQVHKNLSDLEEAMRADDRAnISPSMCYAYAAIAEGAPFVMGAPNLCI 225
ASM67271            143 LRQDIRDFKAANNCERIVVLWAASTEIYIPLSDE-HMSLAALEKAMKDNNTEvISPSMCYAYAAIAEGAPFVMGAPNLCV 221
jcvi:cds.PERMA_1920 133 IEKDILEFKD----DETVAVNVASTEPVIPYDQEVHGSLEGFERAIKENRKDrISASMIYAYVSLKNGIPYGNFTPSAGS 208
Q9Z4Y8              121 IVADLTGFRERLGLDRVVVVNVSSTQPPAVPHPA-HASAAALREALAR-GERpLPVSSLYAYAALRAGCAFVDFTPSTGA 198 Streptom...
jgi:Isova_2168      140 LAADVVAFRERHRLARVVVVDLASTEPPVEPLPE-HDDVDALRAALADPARTvLPPSSVTAYAAVLAGAPYAAFTPSAGM 218
XP_002259699        320 -VNGVVQLAQQKGIFIVGNDLKTGQTKIKNFLLDFYFGTGLKPKSIVSYNHLGNNDGKNLSSDLQFYSKKISKSNLICDY 398
WP_013445918        223 dVPAMVELSHRTNTPIMGKDFKSGQTLMKTILAPGLRARLIGLDGWFSTNILGNRDGEVLDDPGSFKSKEVSKSGVLHD- 301 Paludiba...
WP_014217577        223 dIPAIVQLANKTKTPIGGKDFKTGQTLMKTIVAPGLAARSLGVTGWFSTNILGNRDGLVLDDEQNFKTKEVSKLGVLED- 301 Niastell...
CDE57758            226 dIPAMWELAEQTKMPIAGKDFKTGQTLVKSGFAPIIGTRCLGLNGWFSTNILGNRDGLVLDEPANFRTKEVSKLSTLET- 304
CCX67001            227 dIPAMWQYAEKTGTPIAGKDFKTGQTMMKTVLSTAFRTRMLGVSGWFSTNILGNRDGLVLDVPENFKTKEVSKLGVIDT- 305
CCY16111            226 dIPAMWEFAEKQNVPLAGKDFKTGQTLMKTVLAPMLHTRCLGLSGWFSTNILGNRDGEVLDAPENFKTKEVSKLSVIDTI 305
ASM67271            222 dTPAMWEFSKQKNVPIAGKDFKSGQTLMKTVLAPMFKTRMLGVNGWFSTNILGNRDGEVLDDPDNFKTKEVSKLSVIDT- 300
jcvi:cds.PERMA_1920 209 gIPALKELAEKNGVPHAGNDGKTGETLVKTTLAPMFAYRNLKVLGWMGYNILGDLDGKVLSHKQNKESKVVSKDK----- 283
Q9Z4Y8              199 rLPALDELAREQGLPYAGSDGKTGETLVKSVLAPMFARRALRVRSWSGTNLLGGGDGATLADPERVVSKNASKGL----- 273 Streptom...
jgi:Isova_2168      219 aIPALTRLAAEAGVPVAGQDGKTGQTWLRTVLAPAFAARGLRVLSWAGTNLLGGGDGATLADPENVRSKLATKSR----- 293
XP_002259699        399 vkanehmyadeeeektlsnkfmkesgdyckgdslvststdvtdleADYAYVDAIENQKVNSEIVIKYVPYVGDDKKAIDE 478
WP_013445918        302 ---------------------------------------------ILEPELFPELYGNTYHKIRIEYYPPRGDFKESWDC 336 Paludiba...
WP_014217577        302 ---------------------------------------------ILRPDLHPDLYGELYHKIRINYYPPHGDNKESWDN 336 Niastell...
CDE57758            305 ---------------------------------------------ILEADKQPDLYSNYYHKVRINYYPPRNDNKEGWDN 339
CCX67001            306 ---------------------------------------------ILKKDEYPDLYGDIFHKVRINYYPPRNDDKEGWDN 340
CCY16111            306 l--------------------------------------------DKNELPELYSDIYHKVRINYYPPRGDNKEGWDNLD 341
ASM67271            301 ---------------------------------------------IFEPEKYPDLYGDVYHKVRINYYPPRKDNKEAWDN 335
jcvi:cds.PERMA_1920 284 -------------------------------------------------VVSKILGYEPYTITEINYFPSLQDNKTAFDF 314
Q9Z4Y8              274 -------------------------------------------------VLEAELGHAVEGGVHIHHVPDLGEWKTAWDH 304 Streptom...
jgi:Isova_2168      294 --------------------------------------------------GLRDLTGSDTTPLHIDNVPDLGDIKVAWDH 323
XP_002259699        479 YISEIFMNGKNTISLYNVCQDSLLASPILIDLILLVELSQRVYFKgdfltssgivaapqskisnpinvggdyqlnhtive 558
WP_013445918        337 LDIFGWMNYKMQIKINFSCRDSILAAPLALDLALFIDLAKRADMR----------------------------------- 381 Paludiba...
WP_014217577        337 IDIFGWLNYPMQIKINFLCRDSILAAPIVLDLALFADLAQRAGMY----------------------------------- 381 Niastell...
CDE57758            340 IDIFGWMGYPMQIKINFLCRDSILAAPLCLDLVLLSDLAARAGRF----------------------------------- 384
CCX67001            341 IDIFGWMGYPMQIKVDFLCKDSILAAPLLLDLALLGDLALRAGKS----------------------------------- 385
CCY16111            342 IFGWMGPDYGMQIKIDFLCRDSILAAPLMLDLVLCADLAARAGWT----------------------------------- 386
ASM67271            336 IDIFGWMGYPMEIKVNFLCRDSILAAPIALDLVLFSDLAMRAGMC----------------------------------- 380
jcvi:cds.PERMA_1920 315 IHYQGFLGTKMKFYFTWDAVDAIVAAPLVLDIARFLNFAKKKGVK----------------------------------- 359
Q9Z4Y8              305 VTFEGFLGARMTLQFTWQGCDSSLAAPLVLDLARFMALAHRAGVA----------------------------------- 349 Streptom...
jgi:Isova_2168      324 VHVEGFLGSRLTLQTTWSAYDSMLAAPLVLDLARLLALAHAAGVA----------------------------------- 368
XP_002259699        559 akypefkkmeCVLFLSSLFCKSPFNS--SVYKTRHSFFSQLESLCNYVR 605
WP_013445918        382 ----------GVQEWLSFYCKSPQTA--QGLPAQNDVFKQLEKLENTLR 418 Paludibacter propionicigenes
WP_014217577        382 ----------GVQDWLSFYLKSPQTK--QGEPAENDIFKQLNTLKEVLR 418 Niastella koreensis
CDE57758            385 ----------GIQRFLSFFLKSPMHDytQGEEAVNHLFQQYVMLKNAIR 423
CCX67001            386 ----------GIQTWLSFYLKSPMHD--DEHEPVHDLFQQYTMLKNAIR 422
CCY16111            387 ----------GIQTWMSFYLKSPMHDyvKGIEPVHDLFQQFAMFKNAIR 425
ASM67271            381 ----------GIQTWLSFFCKSPMHD--FEHQPEHDLFTQWRMVKQTLR 417
jcvi:cds.PERMA_1920 360 ----------GVVKELAFFFKSPMDT------DEYNTHKQFETLVNWYR 392
Q9Z4Y8              350 ----------GPVPELGFFFKDPVGS------AEHDLAAQYASLAAWAR 382 Streptomyces coelicolor
jgi:Isova_2168      369 ----------GPVPELGFFFKDPWAS------DTHDAAAQAAELQAWAR 401
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