Conserved Protein Domain Family
BUD22

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pfam09073: BUD22 
BUD22
BUD22 has been shown in yeast to be a nuclear protein involved in bud-site selection. It plays a role in positioning the proximal bud pole signal. More recently it has been shown to be involved in ribosome biogenesis.
Statistics
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PSSM-Id: 401132
Aligned: 65 rows
Threshold Bit Score: 60.6185
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERS97129       52 YtDVLRMLKKARGFERQRLVRRIaeeKTQSKtgkkskgkkakksaadnvdgdgdgdtDQRSERLQRLE------------ 119 
EKD01031      688 RtKLHQLFKQAKREESQRLIKKI---KFLSK--------------------------KGSSSEADELD------------ 726 
Q5KCW5         93 K-SLHPVFKQAKTFETRRLIKKI---KFLRN--------------------------KDVKDETADLE------------ 130  Cryptococcus ...
XP_001876195   22 K-EVHKASKKAKVFETQKLVKRL---KDLRRk-------------------------GDDPKAIEEHE------------ 60  
EAU85862       34 Q-EVYQACKKAKTFETQKLVKKL---KGLRKd-------------------------SSDTNAVQEHE------------ 72  
EGN98387        7 R-EVRKAAKKAKTFETQKLLKKL---KDLRRk-------------------------AEKPNEITDAE------------ 45  
XP_007399343   24 K-ELKKAAKKAKDFEIRKLVKRL---KGLRVk-------------------------KPAPPELRDLE------------ 62  
NP_492224     116 V-ALRATCLTAKNQLMSRIVRQK---KQLE---------------------------SKKSQKVDGKSkeerdrkiarlv 164 
XP_006959516   44 NvDLRRATKDAKTSERQRLQKKI---TQAEKksa--------------------kgeEIDRVQLEETQ------------ 88  
EOQ99199      122 HvDLRRAVKDARVSEHKRLQKKL---TQLEKmss--------------------kgeKVDSQQQEEAQ------------ 166 
ERS97129      120 REVEVLKTLDYEVTAR-VHLANAMLRTRGLAEAPgplgahlqLASEVLS-----------QRTKAYRTDDIHNVTSALYN 187 
EKD01031      727 TQLKLLGAVDLHILSA-NHLKLKLRKHYLLKKDG--------MPSDVESviggg--qtvkASGSNATPEVIAKVENRLCS 795 
Q5KCW5        131 SQLKIIHDIQLQPLAK-SHLLVKLRKHPLFKQTP--------LPSEISSllsppsattasFAGTSATPALINKAENRLCS 201  Cryptococcus ...
XP_001876195   61 EQLTLLKSVDHDTIGN-TAFKTKILKDNSLRENDf-------VQAALSSevgenvt------tpakpgTPLAKVQSRLLS 126 
EAU85862       73 AQLTALKELDIHSIAR-TAFKTKVLKDRTLRDSEl-------IMSGLEKeitnti-------ipspasTPLGKVQSRLLS 137 
EGN98387       46 AQLDAIKHITLDVIAD-TALRTKMNKDHILSTNEd-------LQHALSMellpspi------asaaagSHLAKVQSRLLS 111 
XP_007399343   63 EQLVLLKEIDHKTIAS-MALKTKLKKDKQLSENEn-------LVAAISQelscli-------vpaqpgSNLAKVQGRLLS 127 
NP_492224     165 EEILGLKTFDKDSVAKfAALNTKSLAELKINGKT----------------------------------EVAERLMYKLVC 210 
XP_006959516   89 NQLNETKDYDGLIAAQ-HTFFSKLSKH-----SSgayktreeVILALKNlnfdfpni------aqasnapeGKLAARFMS 156 
EOQ99199      167 NQLIETKEYDGLPAAQ-HTFFSKLSKH-----NQgafksreeVIHALNKlsfnwpai------slpsnapqGKVAARFMS 234 
ERS97129      188 RPFVRDAVAKAVA-GM---CQLLGLPP----------PEKSVSRVRKQRKEEDEEED------------EEEEKDSVDdd 241 
EKD01031      796 AKNVADGVKGIVSwCLaepGSSLNLDKmkekknkknaKPESDEDSDDASEGDDEREDdva-------nvVGELDSDDEvv 868 
Q5KCW5        202 AKIVAERMKNVVSwTVcegGAKLVIEKkpatisagkgGSKKAAESTDEEDDEQEEGEeanv-----gdiSRSMVNGSD-- 274  Cryptococcus ...
XP_001876195  127 SKLLAAQIVVSIE-NL---RMLLDPTLrgpka-egteEDTAVPAPKRKKAPTLSGEQsvah-----aamEDCESDGDE-- 194 
EAU85862      138 SKHLSSQISISID-GL---KVILDPEYapqqkkqrttSAEPPNAASIASSKRTRTQRhskegslqaadvGSESEDSED-- 211 
EGN98387      112 SKVLASEISIVIG-GI---KATINPAFaaaqd-aaseGESDADVPAVPRKTKRVSADkst-------------------- 166 
XP_007399343  128 HKVIAAEVHTIVE-DV---RTTVFPELkltavteasdGELHEDVPLRPTKKVKMVSAgp---------eKTDEGDSDD-- 192 
NP_492224     211 QSIIVEKIQSIREkYTewnKTAAFFMQrlgqq-yankPEKKSKKSTEKKELNIENLEd----------lNNEDEDSEN-- 277 
XP_006959516  157 IEQVSKVAKAGVD-SV---SSILGDSA----------AEKQKQSEQLEDSKESAEDDevd-------dkLESNTTSDKpa 215 
EOQ99199      235 IEQISSVAKSAVD-SV---VSILGDGA-------------------------KKENEvnvqa--eqvpaDDKQIKNDKtl 283 
ERS97129      242 trrhtqantpkdktIAWRSESSEDEEADDDNDEDTEDnmeyneaddkaie------------------------------ 291 
EKD01031      869 ve--------ekaaDAAGWESGDLGGEGSDEDDEEGEdgwesgsvggee------------------------------- 909 
Q5KCW5        275 ---------------SEEDSDDERVLQDRAAD----Aagwes-------------------------------------- 297  Cryptococcus ...
XP_001876195  195 ----------------WKGVDDENQDMADAAIGDGVDdgwesgtvgegdd------------------------------ 228 
EAU85862      212 ------------------DDLRDEEGADDESEDGDGAdgwesgsisgdedyvgrl-----------------------ap 250 
EGN98387      167 -----------hghSMSVPEKNEEDGGNAEEDENILDdgwesgtisggdqas---------------------------- 207 
XP_007399343  193 -------------------ESSLNNRVTISDEEEVADdgwdsgtvhgesdseeeed---------------------nka 232 
NP_492224     278 -------------------EKEEEIEENEEDydqsd-------------------------------------------- 294 
XP_006959516  216 p-----------reQKATPTIDSSALIAKLTGALGGVvrddededndaqsdagsdisaplsgytsgeasneedalkdwpe 284 
EOQ99199      284 qp--------ptqiKKERPATDNSALIAKLTNSLGGTvrddddeeeedqeadsdaplsgytsgeasddalqnwpdpdads 355 
ERS97129      292 ---relakfesrlgsDEDDDEDesdendseddglgsgsdddsdgdldddavvaklrakyaaavakglwqdddrdrddfsg 368 
EKD01031      910 ----gtgedawiasaSDSDAPDyaalanl--------------------------------------------------- 934 
Q5KCW5        298 ----------gsvsgFDSEGGE---------------------------------------------------------- 309  Cryptococcus ...
XP_001876195  229 ---vagsdgwesssiGNDDDVSedgdrlel-------------------------------------------------- 255 
EAU85862      251 sspvgsdeensgseqDDDDDSD---------------------------------------------------------- 272 
EGN98387      208 -edewesgsvddvhhGTKEDGD---------------------------------------------------------- 228 
XP_007399343  233 edngvasevktkdgeSDDEDTvsrs------------------------------------------------------- 257 
NP_492224     295 ----------iemldSDEEEAGee-------------------------------------------------------- 308 
XP_006959516  285 peeevdesneeeeeeSDDEDEG---------------------------------------------------------- 306 
EOQ99199      356 dgdddnddinnddinNDDDDAD---------------------------------------------------------- 377 
ERS97129      369 edsdgadfeeeqdDEQGEGGEEEEEFGGFSDDGEVDDESESESDED-----------------LRPRKRKATSATTFDgT 431 
EKD01031      935 -------kggageDWSSGSEGDSDAGSASDSSSGSSVAVERPPAKKvkaevskkaekpvkaekKPEKKAAKAEKPKPDgT 1007
Q5KCW5        310 ----------------VDIASESESESDNSDAIAVPSAKRAKTAVPplppk--------skplKSEKADKPPKSAKDLtS 365  Cryptococcus ...
XP_001876195  256 --------------------------------------------------------hakpavkKSATAALKAKASASGlQ 279 
EAU85862      273 ----------------------------------------PESDEDtkpmkkanaggstssktPKVASGASSKPAKIN-E 311 
EGN98387      229 ------------------------------------YSSGSEGNLAapss----------pplPNESKPHQGKAKTVGsQ 262 
XP_007399343  258 ------------------------------------------------------------kqpPRKTPPPRASTSKKG-E 276 
NP_492224     309 --------------------------------------------------------------aAKNRRNLLLGLIGVQ-E 325 
XP_006959516  307 -------------------------------------------------------------------------------G 307 
EOQ99199      378 -----------------------------------------------------------------------------N-G 379 
ERS97129      432 SHFLPSL-MG-GYVSdGGDDa------dGVADDE--------EAAArmlggpRKNRRGQRARQAIWEK-------KYKQL 488 
EKD01031     1008 SMFLPSL-AA-GFTA-GDSD--------SDPDMDydpdgvigNKAAp-----RKNRRGQRARQAIWEK-------KYGKN 1064
Q5KCW5        366 SIFLPSL-SV-GFTR-GDDDd-------SDPDLDddpngvagKQPVv-----RKNRRGQRARQAIWEK-------KYGKN 423  Cryptococcus ...
XP_001876195  280 STFLPSL-SV-GFVR-GGSEesdwseegRVADIDv-----------------KKNRRGQRARRAIWEK-------KYGRN 332 
EAU85862      312 STFLPSL-QV-AYIS-GSDDsd-----aEAEVAEp-----------------RKNRRGQRARRAIWEK-------KYGRN 359 
EGN98387      263 STFLPSL-AV-GFAR-GDSDsdw--sesEAKDADg----------------iKKNRRGQRARRAIWEK-------KFGKN 314 
XP_007399343  277 STFFPSL-AV-GFTR-GDSDasdl-sdaEVARAEgg---------------aRKNRRGQRARRAIWEK-------KYGKN 330 
NP_492224     326 DKNRPSL---------------------APKKRKlveeedeeVETV----------KNQKKMKQIFEKelkskevKNPKK 374 
XP_006959516  308 NTILDSLnAGvGYIS-GSDD--------DISDAEe------kVAP-------RKNRMGQRARRAILEK-------KYGRG 358 
EOQ99199      380 NALLNSLnTGvGYIS-GGSD--------DISDAEe------kVAP-------RKNRMGQRARRMIHEK-------KFGRG 430 
ERS97129      489 AKHvLEQEKKGTDAGGKDGGKDKKank---------------------------------------ngkQKDggGGWD-- 527 
EKD01031     1065 AKHiVKQREEEKKKAAKKEGRVGGsnf---------------------------------------vppSRD--SGYK-- 1101
Q5KCW5        424 AKH-VVKAHEEEKLQAQKTREKAEak-----------------------------------------grTRD--SGWG-- 457  Cryptococcus ...
XP_001876195  333 ANH-KKKESEESTKFGSVRGEPPRprqlhnhppssga--------------------srkikptsqqrqPPD--MGWG-- 387 
EAU85862      360 ANH-KKAEAKAApttavkqn-----------------------------------------pegrsfahPKQprGG---- 393 
EGN98387      315 ANH-VKRYQDDPSRRERPTERRRGsqplgqrnsdrp---------------------rkrdtsnqqhqqPPD--AGWNrr 370 
XP_007399343  331 ANHfKKRETFGAVKGYPNKTSDRDvngsrdnprgns----------------------qankrphaqaqSRN--VTYSqr 386 
NP_492224     375 SNKsTKKPTKSAPIVKKVEEKKVEenevsddesdqktlvmkvdlskggkiakaqkfsttapksakivapVSE-------- 446 
XP_006959516  359 ANH-IQKK--FEEQKQLERAKKFGk-------------------------------------------nKLD--SGWKgr 390 
EOQ99199      431 ANH-VQKK--FEEDKQLERAKRMGr-------------------------------------------nKLD--SGWKgr 462 
ERS97129      528 ----AKRGAVDASDK--------PRWLrrkmgllgrvgp-----vggggkgagsnATPPAGAKKEIPNANAQVSGTLHPS 590 
EKD01031     1102 ----TYRPAPESAPVlakpggtfGSSApar-----------------------tpGAATAGGASGPGAGGDEKKGKNHPS 1154
Q5KCW5        458 ----AKSGKAVGPAVaagpaqtaA-------------------------------VSHTQKVYSEPKQSQTEQKKSLHPS 502  Cryptococcus ...
XP_001876195  388 -------------------------------------------------------QRRIGPNKIPPSKSETKADQSLHPS 412 
EAU85862      394 ----VRRGPLVSGPNsaaiqgkqRAF-----------------------------GQKPPTGAAAPSTNSNPSNKPLHPS 440 
EGN98387      371 epsnSHTKSIVGT------------------------------------------RSTIVSSAGSSQRNDRHDERPLHPS 408 
XP_007399343  387 ------------------------------------------------------aSSSHVSSVQTGPTTRKERDKPLHPS 412 
NP_492224     447 ----------DENDDdesssfflPKSGvvaprkiipkkpsenvekvdkrfqkgtqKKSEAVVEKKKGSSKSAVSGEMHPS 516 
XP_006959516  391 qqqqsggykeaerkdfk-------------------rdfkkfdknakqdgksgsgRPPPRNNKPPQKPTKAEDEGPLHPS 451 
EOQ99199      463 qqrqsedqkpnkdlnggykkdf---------kkdnktdsnhsskhdrgyknhskpHSKPSVPIKPGTDAAADDQGQLHPS 533 
ERS97129      591 WEAARKAKD--KAQTAAFEGKKIVFD 614 
EKD01031     1155 WEAARRRKEaeQKLKNAPKATKIVFD 1180
Q5KCW5        503 WEAAKLRKQkmGVVQTEIKAQKIVFD 528  Cryptococcus neoformans
XP_001876195  413 WEAKRKLKLkeSAGIIPSQGTKIKFs 438 
EAU85862      441 WEAKKKLKEk-QSGIVPSQGKKIKF- 464 
EGN98387      409 WEAKKKQK---TAGIVPSQGKKIVFs 431 
XP_007399343  413 WEAKRKLKEkqNPALIAPRGKKIVFe 438 
NP_492224     517 WIASQLKKK--ELASAKPCGKKITFg 540 
XP_006959516  452 WAAKKAQAKaiENAPAP---TKITFD 474 
EOQ99199      534 WAAKKAQAEaiANAPAP---TKITFD 556 
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