Conserved Protein Domain Family
Treslin_N

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pfam15292: Treslin_N 
Treslin N-terminus
This family represents the N-terminus of treslin, a checkpoint regulator which plays a role in DNA replication preinitiation complex formation.
Statistics
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PSSM-Id: 464618
Aligned: 19 rows
Threshold Bit Score: 1075.46
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_218829     211 LYWVDTTERSKLWASPDHTGYWTVCELLHHGGGTILPaETWNLGFTKARETVLPCGG----ELSPGPHLSPWISALPIDA 286 
XP_005460037  214 LHWIDCRSYVQVMRCEDYFGCDKLSEVLAQMDGRIIP-VVALLNLCSAQQPNSGFMR----------------ESFAFKS 276 
XP_014327371  216 LHWIDTRPHVEVMSCEDSFGFDKLSAVLAQAGGRVIP-LVALLNLCSNHNSDPGLRR----------------ESSLFSS 278 
XP_011474099  211 LHWIDTRSYNQVVSCEDHLGSDEVAGVLSQVGGRIIP-LVALLDLCCQQKSDSRLAK----------------DAFGLKS 273 
1_pfamImport    1 LHWIDSRSQ---IICEDHLSLDK---ILARLGGRVIP-VVALLNLCSSQNPDASFRR----------------ETFTFRS 57  
XP_007244308  216 LHWADFSVYKHTNESDDYMGLKTITEVLQQVAGKVVPvLTPTVAPKREHEHPNLGIT----DITARLQ------ALPTSS 285 
Q6DRL4        220 LHWADSGVFKADHVAKDYTGIETLMERLGLVGGQVVPmLSPCLPLMDQHPKMNSLLAlg-------------vDAFPIDS 286  zebrafish
XP_011605365  214 LHWVDSRSREQVMSCDDHLGFERLSEVLAQSDGSIVP-LVTMLDLSSSH------------------------KNLALKS 268  torafugu
XP_008118383  209 LYWVDTTEPMKLLESPDCMGYRLLSDLMLLLGGTILPsENFIHYLNHQRGGTVSAVPvkfwDAEPALN-----KTLPFDS 283  green anole
XP_005051905  124 LFWVNTADWAQLIECPDHGGYWTMFEVICQMGGTILPaEALVHCLSHPREDATPGFLg--dSRFPVPQAVPWATLLPLDG 201  Collared flyc...
XP_218829     287 TVNCLLYNS-EYEASFPRVEGTLFLPVK-GKEIQ----ETWAICLEPLAMHQRHFQKPVRIFLKGSVTQWSLPMSSALGT 360 
XP_005460037  277 SIGYLLSSErHYRLAFPVIGGVLQWQQ---GDVT----QSCGVMLEPVTRRQKLLPESVKMSLKEVLRGWDASSLIQTST 349 
XP_014327371  279 SVGFLLSSErLYRLAFPASDAVLRWDH---GNES----HSCHVVLEPVCRGQHLLQESAEVYLKGALQGWDASCLTQTPT 351 
XP_011474099  274 SIGYLLSSE----SLFQQARGVLRWDQ---GNIA----QSCAVTVEPVLCRQRIPQEPVEVCLKALVPCCDASSVTQIST 342 
1_pfamImport   58 GIGYLLSSErQHSLAFPAIGGVLRWEQ---GDRT----QSCGVTVEPVSRRQRLLPESVEVCLKGVLQDWDDSSLTQTPT 130 
XP_007244308  286 TVNYILSSEkTYQWAFPAVVGNLCWGA---DEEK----QMCSVSLEPVSCTQRPLCTPVTVTLRTVLEGLDTSSLRQSAS 358 
Q6DRL4        287 TNSYLHLSKrMQQQLFPPLGASFSWIADgTK-------RSCNVTLEPVSYRQRSLRAPVDVLLKGVLQSLDILSLSHSAI 359  zebrafish
XP_011605365  269 SIAYLLSPEnVHRLAFPVVSGTLQWNQ---GDRT----QCCHILMEPVCRRQKLLPECVSVCLTAVLQDWDSSSLTRTTS 341  torafugu
XP_008118383  284 SLNCLFSLPsVLQATFPPLEGVLFLRTD-----EigevQSCAVTLEPLTLSQQCFKGPVNISLKCAVTGWNAVHIESFYA 358  green anole
XP_005051905  202 TLNCLFSRPsVYRSVFPQQEGTLFLSMPgGKKQ-----ESCAVILVPLAMSQRQLECPVSIFLKGSLTGWSLAQAGQFLT 276  Collared flyc...
XP_218829     361 DNWMLQSPEEHKSTQRL-LFQELVSRLTAEEFHLVASVDPGDGWPPITGIISPFSANAMILTVL--RAKEAEFQRHFLQT 437 
XP_005460037  350 ESWVIHGSSSGDQGAAA--FQHLLMDLSTHALHVLAEV--NDNGLLCSAVLSPLSYSTALLSIL--QPVIAQSNQRLTTE 423 
XP_014327371  352 EPWLLQLSSSSDQEAAA--FLPLFTQLSALSLHMLAEV--SHSGLSCPAVFSPLSHSTALLTIL--QPIVIQHDQLLKTN 425 
XP_011474099  343 ESWVLK----GDQEAAA--FLQLLRELSSLDSNMLAEV--NVGGLVCSAVLSPLSHSTALLTVL--QPEIPQQNQLLKTN 412 
1_pfamImport  131 ESWVLQCSSIDDQGAAA-AFQHLLMELSSHALHMLSDV--NDSGLVCSAVFSPVSHSTALLTIL--QSEVTQHAQFPMTD 205 
XP_007244308  359 ESWVLVCPQKTEPSHAA--FHYLLNELAVQSSDMLAEV--VEGGLIRSAVLSLLSPHTALLTLL--QPLSTQSKEVLDTN 432 
Q6DRL4        360 ETWILQCPDAELGQEA---FQHL-KQLSTGGHAMLAEV--SEGDVVCSAVLSVLSSCTAQITVL--QPLLAQEGQLLPAD 431  zebrafish
XP_011605365  342 ESWVLHSSNKSAPEAQA--FQHLLMELSAGCLHVLCEV--NDHGLLSTAILDPLSPSAALLSLL--DPDISHHHLFLTSE 415  torafugu
XP_008118383  359 ESWILRSTSSRPSCKEPsLFQQFMKYILAQGLHLVAEVYQFGASSPCTGIFSPISDSTAILSHLsaEQAPEVETFLLQTT 438  green anole
XP_005051905  277 ESWILQSSQAEQGECNRsLFHQLLRSLVAEGLHMIADVSLSETWCPCTAILSPLSEDTAVLTVLgpKKTADIWGCSLEGA 356  Collared flyc...
XP_218829     438 AVTEGSQDVTSLFSDAVDSVLNQVHNSFE---DPASS---VSRVPEWVQQEL-SRTSPWSPALVEKWFPFSNVCGATSDL 510 
XP_005460037  424 VITPASAETSADLPDIVNSVLGVVYDIMKqdgDSVNDqlkENPIPEWAQQEF--SHSPPATNMLETWFPQSDYSGVSSHL 501 
XP_014327371  426 ISSPVEMETSADLPDVVNSVLGVVYDIMNqdgDGTDDeirDPPAPEWAAQEL--SHRSPTTHTLEAWFPQSDQSGVSANL 503 
XP_011474099  413 AEAP---QTTTDLPDVVSSVLGVVYDIMNndeDAVNDkiqDPPVPEWAQQEI---SHPLTTSLLETWFPLSDLSGVSSHL 486 
1_pfamImport  206 IAV-ATAETSAQLPDIVSSVLGVVYDIMAedeD--EDavdDGQVPEWAQQEV--THCPLTTGVLESWFPQSDQSGVTSHL 280 
XP_007244308  433 LISSETAHNSTDLPDIVSSVLNVIMK--E---DDSTEqihQHLLPEWANQEL-QQWRNLATDLSERWFCLSDQSGISCNL 506 
Q6DRL4        432 LVSLDTTDISGDLPDVVSSVLSVMYDIMEe--DDCSDhekMPLVPDWANQELkQQSSSRSNGMVEGWFPLSDQSGISCHL 509  zebrafish
XP_011605365  416 TTTSAPKRSSSELPHAVNSVLGVVYGIMEd-sDRMDVplgDPPVPEWAQQEV--IVHSLSCGVLESWFPLSDQSGVSSHL 492  torafugu
XP_008118383  439 RECHVTKDDDLRVREIVSNVFNQGCDDLErnhMGSAEcqeEASFPEWAQQEL-SRTPCWSPAVMEGWYSLSNFCGASSHL 517  green anole
XP_005051905  357 VVEDSSQDCATQLPDIVNSVLSKIDMPVE---DSLASlgeETPVPEWVQREL-SHTGGWHPSVLEAWYPASNACGASSDL 432  Collared flyc...
XP_218829     511 MESFLLLHAASPDNNESSRt---ESELTRCLSELYQRRSHEEStvVNQERSRKKRGIPRTPVRQKMNTMSRSLKMLNVAR 587 
XP_005460037  502 MESMRLLHAVPEEREEENLpa-lQQELLSGLAEIYQSSQDSE-------KRGRKCGAHRTPVKQKMKTMSRSLQMLNVAR 573 
XP_014327371  504 MESIRLLHAVPDEGSTDNLfe-aQQDLVSGLSELYQESVSKK---------GKKRGAHRTPVKQKMKTMSRSLQMLNVAR 573 
XP_011474099  487 MESFRLLSAVPEQSEEEEAcl-lQQELIGGLSELYQASQDHV------NKRGRKRGAHCTPVKQKMKTMSRSLQMLNVAR 559 
1_pfamImport  281 MESMRLLDAVPEQREEVEQsv-lQQELISGLAELYQTSRGEE------AKRGKKRGAQRTPVKQKMKTMSRSLQMLNVAR 353 
XP_007244308  507 MESMRLLHAAPEEDEEKEEd--aQRELTHSLAELYQNNRAGH----TTGPKGKKKGTQRTPVRQKMKTMSRSLQMLNVAR 580 
Q6DRL4        510 MESMRLLHAAPEEKEKGEEysdtQQEITSSLSEFYQSSTAGS----SGSLRSKKRGTQCTPVRQKMKTMSRSLQMLNFAR 585  zebrafish
XP_011605365  493 MESMRLLHAVPEQQVVDSSa--lDLELISGLADVYQTSHNGG------DGQPQKHGAQRTPVKQKMKTMSRSLQMLNVAR 564  torafugu
XP_008118383  518 MESFRLLLADSATEEEEASk--pEAELTHCLSEFYQRRVSDQSaaSRQQDHRKRRKLPRTPVRQKMKTMPRSLQMLNVAR 595  green anole
XP_005051905  433 MESFRLLQVPCANREDGAEq--sDVELSESLSELYQRKFSETSaaAGPGNNKKRRGVPRTPVRQKMKTMPRSLQMLNVAR 510  Collared flyc...
XP_218829     588 LNVKAQKLHPDGSPDMAVEKGLPKTVIGRTADKLEDRGRVLRSskLKEFKTEEELLAYIHDNYQKTVATGEITLHSCAQN 667 
XP_005460037  574 LNVKAQKNQAESEQVGTEGREADRTGKRRSSDRNKPGVAN-----VISFKSESELLSHLKSSYEKFMAEREESVFMGVQQ 648 
XP_014327371  574 LNVKAQKSQSEAEPPGA-----DRAGKRRLSDRNKPA---AAS--ALSFSSEKELLCHLKACYDKTVAETDSSLLTSAQQ 643 
XP_011474099  560 LNVKAQKNQSEEEQMATESRTVDKPEKRRTSARGKSAGQS-----FVSFNDEAELLTHLKTSYDKTVAEKDSSLLKVVQQ 634 
1_pfamImport  354 LNVKAQKDQAEAEQLGAEGTAPDRPGKRRSSDRNKPGEAN-----AISFASEAELLSHLKCCYEKTAAERDSSLLAGVRQ 428 
XP_007244308  581 FNAKAQKSQPEADLSST-TRATEKQDRRCSSERTKKG--------PTSFKSEEEMLSHLKLRYQQAVEDKSLPLRTQVQD 651 
Q6DRL4        586 LNVKAQKTQGDSGSAGS-GKGTEKGGKKSSGDRTKPG--------LLHFSSEEELLSHLGLTYQKAVENRTMSVPSQVQD 656  zebrafish
XP_011605365  565 LNVKAHKTQSEVEEREV----LDRPARRCSYRNKHRETNT------TYFSSEEELLSYLKSSYDTTVSGREPGLLAAARQ 634  torafugu
XP_008118383  596 LNVKAQKFQPEGEPPIS-EKASQGLLSKPSEDNVNGKGRTAKS-----FRTEEEMLSYITTNYQKAAIDGE-NLLTHAQD 668  green anole
XP_005051905  511 LNVKAQKFQPDAVPPAVNEKIPQKLSAKRLDEKVEGKAKALKIt--iDFQTEEELQSHLTASYQKAVAEGIPS-SVCAQS 587  Collared flyc...
XP_218829     668 TVSTIKIFLKSKDVkELEMTCMNHMNSNLLKTSKTLRQN-LGGKTDKEDKVRECQLQVFLRLEMCQQCPSVLDRTEeVEH 746 
XP_005460037  649 LVSSVKAFLAAES--DWEAKTSLLVQQHLLKTSKSIRQL-YGMAADVDSKVRECQLQVVLRLELCRLFSTEQSDSLdVDQ 725 
XP_014327371  644 LLNAVKTFLTAES--DWEEKASLLVEQHLMKTGKSIRQL-YPAADDANSKVRECQLQVMLRLELCRRVASKQS-RLdADR 719 
XP_011474099  635 LVTAVKAFLEAKL--TGQGQTSLFIQNHLLKTSKSIRQL-YGADADTDSKVRECQLQVMLRLELCSMLASEPSDSLdSDQ 711 
1_pfamImport  429 LMFAVKTFLGTES--DLQIKSSLLVQQHLLKSSKYIRQL-YGAAADIDIKVKECKLQALLRLELCRLFPTGQSDSLdVDQ 505 
XP_007244308  652 VFSMVKTFTKKHT--DAEALFLDLVKKNILKSAQSIRQL-YGSTPDTESKIRDCQLQVVVRLEICRH-PSSDQDSDdVEQ 727 
Q6DRL4        657 LLSVVKSFLKSNT----EASLLNLVQKHVLKSCQSIRQH-YGNSSDDESKIRECQLQAVLRLELCKQ--TEQEDEEvVEQ 729  zebrafish
XP_011605365  635 LLSTAKTFFSAEA--DMLVRHTGFIRQHLLKSSKSIRQIcASAAAAAENKVRECQLQALLRLELCHL----SSSELdIDH 708  torafugu
XP_008118383  669 MVATVNIFQKLNE-----AAFLDTVKSSLLKTSKALRQQ-LGSDPDQEAKIKECQLQVYLRLEMCRQCPSLQNNIDgMDQ 742  green anole
XP_005051905  588 MIMAIKRFLKIPDAkEKEVACVGRVRNHLLKTSKMLRQQ-HGS--QKETKVRECQLQVFLRLELCLQCPSLQSNAEeMEQ 664  Collared flyc...
XP_218829     747 VVE--EVTDLLRVVCLTKDSA-YLSEFL-EEILGLYIDSIPGTI-----GQLYHSLGLKIPQKLAGVLPTDFFSDDSMTQ 817 
XP_005460037  726 MAE--EVAEMLRIISLTRDPV-FLTRFLqDEVLPGFLTAIPRVL-----AEIYHSLGTQLPEVLLAVLPPDFFSDDSVAK 797 
XP_014327371  720 MAE--EAAEMLRIISLTKDPA-CLARFLqDKVLPGFLTAVPKVL-----ADVYNSLGTQLPDALVAVLPADFFSDDSVAK 791 
XP_011474099  712 MTE--EAAEMLRVISLTKDPV-FLSRFLlDEVIPGYLNSVPRDL-----ANIYHNLGTQLPEALMAVLPADFFSDESINK 783 
1_pfamImport  506 MAE--EVAEMLRIISLTKDPV-CLAMFLgDEVLPGFLTAVPRVL-----ADIYHSLGTQLPEALVAVLPSDFFSDESVAK 577 
XP_007244308  728 MVE--EVAGMLRIISLTNDPV-YLSKFMqEEILPLYLKEIPKIL-----ADIYNSLGTQVPEVLAAVLPSDFFSDDSMAK 799 
Q6DRL4        730 RVE--DVADMLRNISRSKDAV-YLSRFMqEEVLPLYMNSIPKVL-----ADVYHSLGTQLPEALVAVLPSDFFSDESLAK 801  zebrafish
XP_011605365  709 VSEevEVAELLRIISRTKDPV-YLARFLqDDILPGFLAGIPCIL-----AEIYHSLGTQLPEALLALLPADFFSDESISK 782  torafugu
XP_008118383  743 LVE--ELTEMLRILCLTKD-PgYLTRFL-EEVVDVYM-----ETmpkilGDLYYSLGTQIPAKLASVLPADFFSDDSMSQ 813  green anole
XP_005051905  665 LLE--EVTDMLRILCLTEDPA-YLTKFL-EEILELYMNSIPKTL-----GGIYYGLGTQIPPKLASVLPSDFFSDDSMTV 735  Collared flyc...
XP_218829     818 ESMSP---PPSSSTHRSVSAITE--S-EQLEELRTRSAKKR------RKNALIRHKSIAEISQALRQIEVPKVSKRATRS 885 
XP_005460037  798 DSISP---SASSLSLSAQCLVSDd-K-DGLQDLRNRSGNKR------RSGMLTRHRSMTESSQSLRQIEIPKKATRASKS 866 
XP_014327371  792 DSISP---SASSHAVSAQSLVSD----DGLHDLRNRSANKR------RSGMLTRHRSMTESTQSLRQIQLPKKTTRASKM 858 
XP_011474099  784 DSISP---SVSSSNMSASNLASNg--nDGLQDLRDRTVNRK------RSGMLTRHRSMTESSQSFRQVEIPKKTSKAPKP 852 
1_pfamImport  578 DSVSP---SASSGPLSTLSMLSDg-S-GRLQDLRNRSAGQR------RSGMLTRHRSMTESSQSLRQIEIPKKTTRASKS 646 
XP_007244308  800 ESVS-----VGSTHSATQSVVSSv--gNRLEELRNRSAKKR------RTSVLSRHKSMTEASQALRQIEMPRKSTRQSKS 866 
Q6DRL4        802 DSVSV---SLSSFS-ATQSNISSv-G-DHLEELRNRSAKKR------RQSMITRHKSMTEAPQALRQIEMPRKSTRLAKP 869  zebrafish
XP_011605365  783 DSVSP---SAPSAGHSVSSLLSDg--gDQLQNLRDRSANQR------RSGVLTRHRSMTESSQSLRQIQMPTKTTRAAKL 851  torafugu
XP_008118383  814 DSQAPsvhPSASSVPVSSIVS--------LSTEAEQLEELRtrsakkRKNTLARHRSVTETSQNLRQIEIPQVPKHRARK 885  green anole
XP_005051905  736 DSQSP---GLPPSLSSVLTPSAVcsEsDQLEELRTRSAKKR------RNNVLARHRSMTEAPQNLRQIEIPKVAKNPVRK 806  Collared flyc...
XP_218829     886 ESAHPASv----QLPL-PRKDTVQEVTKVRRNLFNQGMLSPSKRGLkkgLPRSRSVSTLECLQHKQDKLKKTksstfQGY 960 
XP_005460037  867 KGRVSLDkp--vEEPH-PPKQETQEVTKVRRNLFNQEIVSPSKKAK---LQRSRSVSAVEGVKRKRSHEPEE------RH 934 
XP_014327371  859 KISTAMEkp-aeVQQP--QKQQTQEVTKVRRNLFNQKIVSPSTKRR---LPRSQSVSAVEGLKRKRPLESEE------KH 926 
XP_011474099  853 GRVASEK-----PPVE-AQKQETKEVTKVRRNLFNQEDVTQPKKSK---LSRSQSVSVVEGLKRKRPDDTEE------RH 917 
1_pfamImport  647 KGSVDLEkp-gePQPK-PQKQETQEVTKVRRNLFNEEVVSTAKKAK---LPRSQSVSALEGLKRKRIPESE------EGH 715 
XP_007244308  867 KNSPALEkk-vvASEP--PQKQVQEVTKVRRNLFNQETVSPSKKAK---MPRSQSVSALEGMKKRKRSQIDE-----DQN 935 
Q6DRL4        870 KLCVPIEkt-avEQPP-LPKQPVQEVTKVRRNLFNQVTVSPSKKSK---MPRSQSVSAVEGIKKRKRSDVDNd----DRH 940  zebrafish
XP_011605365  852 KVSSAAKtgaerKKEA----SQGSEVTKVRRNLFNQELVSPSKKAK---MPRSHSVSAMEGLKHKCQETEEG-------H 917  torafugu
XP_008118383  886 DNSYACLd---vKSAPaPQKAAGQEVTKVRRTLFNENILSPGKRSLa-kMSRSRSVSALEGLKHKRSHSKESp---rENQ 958  green anole
XP_005051905  807 ENLRSYPateksQQMPlLQKEAVQEVTKVRRNLFNEEIISPSKRSLk-kMLRSQSVSAVEGLKYKCTSEGNK-----DHR 880  Collared flyc...
XP_218829     961 KLLTKSVAETPVHKQISRRLLHRQIKGRSSDPGPDIHVVEESPEK 1005
XP_005460037  935 RLLTKKVCETPLHKQVSSRLLHRQKIGRKPVLT-EECIVEESPVK 978 
XP_014327371  927 KLLTKKVCETPLHKQVSSRLLGRLKAGRKSDHK-GECIVEESPVK 970 
XP_011474099  918 KLLTKKVCDTPVHKQVSSRLLHRQKIGRRSDLS-EDFIVEESPVK 961 
1_pfamImport  716 KLLTRKVCETPHHKQVSSRLLHRQKRGRSSVPT-EECIVEESPVK 759 
XP_007244308  936 PLLTKKVSETPLHKQVSNRLLHRQKIGRTSGQT-DMCIIEESPVK 979 
Q6DRL4        941 TLLTKKVSETPLHKQVSSRLLHRQRTGRKSGES-DVCIIEESPIK 984  zebrafish
XP_011605365  918 RLLTKTVYETPRHKQVSNRLLHHQKMGR-SVPT-EECIIEESPVK 960  torafugu
XP_008118383  959 TLLTKTVPETPLHKQISRRQLYKQIKGRCSDPGPDVGIVEESPEK 1003 green anole
XP_005051905  881 KLLTKRVAETPIHKQVSRRLLQKQIKGRSSDPGCDTGIVEESPDK 925  Collared flycatcher
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