Conserved Protein Domain Family
ARL6IP6
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pfam15062: ARL6IP6 
Haemopoietic lineage transmembrane helix
ADP-ribosylation factor-like protein 6-interacting protein 6 (ARP6) is a transmembrane helix present in the J2E erythro-leukaemic cell line, but not its myeloid variants. In tissues, ARL-6 mRNA was most abundant in brain and kidney. While ARL-6 protein was predominantly cytosolic, it is known to bind to SEC61-beta subunit of a protein conducting channel SEC61p.
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Statistics
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PSSM-Id: 405709
Aligned: 7 rows
Threshold Bit Score: 125.342
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001958976        106 QEWHQQVQSHWNASLEWSTRHQLASKLSPFLCGFLVAIFAYGIVYLDSVVPGVNPPSPFTPRSKKRHQdEKNSSLHLSYL 185
XP_002049568        143 QHLSSYVQAQLSAALDWSEQHQMRSKLSPLLWGLIVSVFCYAIVYLDSAVPGVVPPAPFSPRSKQRSR-LRSSAVQLNYL 221
XP_001985865        100 QQLRSYVQAQLSAAFDWSEQHQVRSKLSPVLCGLLVAAFFYLIVYLDSAVPGVDPPAPFSPRSKQRYR-QKSSALQLNYL 178
Q7K0Q0              109 qVLSHQVQSRWNETLVWATRHQLGSRLSPLLCGLLVAAFAYGIVYLDSAVPGVNPPSPFTPRSKKRFReEKTASMHLGYL 188 fruit fly
WGS:AAQB:GK21336-PA 112 QQVGQYVQ----VARDWSEKHQLGSRLSPLLWGLLITIFSYGLVYLDSAEPGISPPSPFSKQTRSQ-RqKKGISLHLNYL 186
XP_017211906        100 EKITTEDGSEVRLLGFWSIL------VLSSMAGVLCCSFSWTLTYFDSFEPGMFPPTPLSS---SRYKkMTGHSFHMGYS 170
Q8BH07              138 ENLKNEDDIHTGLLGFWSLL------IISLTAGLSCCSFSWTVTYFDSFEPGMFPPTPLSP---ARFKkLTGHSFHMGYS 208 house mouse

XP_001958976        186 CALLCG 191
XP_002049568        222 CALGAG 227
XP_001985865        179 IALGSG 184
Q7K0Q0              189 CALFCG 194 fruit fly
WGS:AAQB:GK21336-PA 187 GALLAG 192
XP_017211906        171 MAILNG 176
Q8BH07              209 MAILNG 214 house mouse
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