Conserved Protein Domain Family
G0-G1_switch_2

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pfam15103: G0-G1_switch_2 
G0/G1 switch protein 2
This family of proteins regulate apoptosis by binding to Bcl-2 and preventing the formation of the anti-apoptotic BAX-BCL2 heterodimers.
Statistics
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PSSM-Id: 464504
Aligned: 18 rows
Threshold Bit Score: 119.803
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAI63619      51 MDTMHELIPFAKEMLSAGPSKGSLKIYLVGGTFAVLGMVSGVVQVASSLFPDHEepdfdmlKVREVLPVKQQVQ----EP 126
XP_006089987   1 METVQELIPLVKEMIAQKPSRRLVKVYVLGGVLALFGVVLVLVETVCSPFTAAS-------RLRDEEAAVAELRa---AR 70 
ELK16128       1 METVQELILLAKEMMAQTSKRKLVKLYVLGSVLALFGVVLGLVETVCSPFTAAS-------RLREEEAAVAALRa---SR 70 
XP_007481389   1 METVQELIPLAKEMMAQKPNGKMVKLYVLGSVLAFFGVMIGLVETVCSPFSAIS-------RLREEDAPAATSQa---SR 70 
XP_003220478   1 METMQELIPFAKEMMSQKPNGKMVKLYMLGSVLAFFGVVIGLVETVCSPFTSEG-------KPEDEEEEEEKSPavplSK 73 
ADO85305       1 METMHELIPFAKEMLSQKPNRKMVKLYVLGSVLAFFGVVIGLVEAVCSPFTSEE-------RIEEEEE--KRPTp---SR 68 
XP_005017223   1 METMHELIPFAKELLSQKPNRKMVKLYMLGSVLAFFGVVIGLVEAVCSPFTSEG-------RL-EEEE--KKPAp---TR 67 
XP_005059200   1 METMHELIPFAKEMLSQKPNRKMVKLYMLGSVLAFFGVVIGLVETVCSPFSSQG-------RLEEEEEDKNKPAa---AR 70 
XP_002198688   1 METVHELLPFAKEMLSQKPSRKMVKLYMLGSVLAFFGVVIGLVETVCSPFGSEA-------SP-EEERDKEKAAa---AR 69 
XP_005987723   1 METLQELIPFAKEMLSQKPNRKMVKIYVIGSVLAFFGVLIGLVEAVCHPFTSEK-------MLKEE---VKSPSa---ES 67 
AAI63619     127 QTSIPEDEEmDaVMEAKAKELPsNRQRRMSFRAHAS 162
XP_006089987  71 ERQALQTQA-L-PEKGKQHEDT-LCSRALSNRQHAS 103
ELK16128      71 ERQTLRTQA-L-LEKGKQQEAI-VCSRALSKRLHAS 103
XP_007481389  71 LHESRRREA-L-PEKSKEQGA--LGGRSLSHRQHAS 102
XP_003220478  74 EDFAPQKPEeViLEKCKQE----LAVRNSVTRQRAS 105
ADO85305      69 EPALPRKQEdLvLEQSKKSS---AVQRGMVTRQHAS 101
XP_005017223  68 GQTLPQKQEdLiLEKSKKPV---VMQRALVTRQHAS 100
XP_005059200  71 EQRVPQKQEgLvLDKGKARP---ALHRALVTRHHAS 103
XP_002198688  70 EQPEPQHREgLvLAKGKAAVP--GLHRALVTRQHAS 103
XP_005987723  68 QKPEKNKDEeMvLEKKKQQS---MAVRSTANRLHAS 100
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